MAFA antibody

Principal name

MAFA antibody

Alternative names for MAFA antibody

Transcription factor MafA, V-maf musculoaponeurotic fibrosarcoma oncogene homolog A, Pancreatic beta-cell-specific transcriptional activator, Transcription factor RIPE3b1

SwissProt ID

O42290 (Chick), Q8CF90 (Mouse), Q8NHW3 (Human)

Gene ID

378435 (Mafa), 389692 (MAFA)

Available reactivities

Ms (Mouse), Hu (Human), Rt (Rat), Chk (Chicken), Ze (Zebrafish), Bov (Bovine), Can (Canine), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse

Available applications

ChIP assay (ChIP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of MAFA antibody

Insulin gene expression is regulated by several islet-enriched transcription factors. However, MafA is the only beta cell-specific activator. MafA selectively induces endogenous insulin transcription in non-beta cells. MafA was also first detected in the insulin-producing cells formed during the second and predominant phase of beta cell differentiation, and absent in the few insulin-positive cells found in Nkx6.1(-/-) pancreata, which lack the majority of second-phase beta cells. These results demonstrate that MafA is a potent insulin activator that is likely to function downstream of Nkx6.1 during islet insulin-producing cell development.

General readings

Doyle and Sussel, Diabetes 56 (8):1999-2007, 2007.
Artner et al., PNAS 104 (10):3853-3858, 2007
Park et al., Diabetes 56 (2):431-437, 2007.
Doyle et al., Development 134 (3):515-523, 2007.
Wichroski et al., PLoS Pathogens 2 (5):e41, 2006.
Tweedie et al., Diabetes 55 (12):3264-3270, 2006.
Nakamura et al., BBRC 350 (1):68-73, 2006.
Ueki et al., Nat Genet 38 (5):583-588, 2006.
Smart et al., PLoS Biology 4 (2), 2006.
Shimohata et al., Biochem Biophys Res Comm 346 (3):671-680, 2006.
Ye et al., Diabetes 55 (3):742-750, 2006.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAFA antibody

Immunohistochemistry-Paraffin: MafA Antibody [NB400-137] - FFPE section of mouse pancreatic islet.  Antibody: Affinity purified rabbit anti-MafA used at a dilution of 1:250.  DAB staining using Immunohistochemistry Accessory Kit Rabbit Purified Ms ChIP, WB
0.1 mg / €490.00
  Novus Biologicals Inc.

MAFA antibody

WB Suggested Anti-Mafa Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: Mouse Muscle Rabbit IgG Purified Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAFA antibody

WB Suggested Anti-Mafa Antibody Titration: 0.2-1 ug/ml; Positive Control: Mouse Kidney Rabbit IgG Purified Bov, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAFA antibody

WB Suggested Anti-MAFA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Placenta Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAFA antibody

WB Suggested Anti-MAFA Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: Human Thymus Rabbit IgG Purified Can, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAFA (Center) antibody

Western blot analysis of MAFA Antibody (Center) Cat.-No AP52582PU-N in mouse spleen tissue lysates (35ug/lane). MAFA (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MAFA (C-term) antibody

Western blot analysis of MAFA Antibody (C-term) Cat.-No AP52583PU-N in K562 cell line lysates (35ug/lane). This demonstrates the MAFA antibody detected the MAFA protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MAFA (C-term) antibody

Western blot analysis of MAFA Antibody (C-term) Cat.-No AP52584PU-N in WiDr cell line lysates (35ug/lane). MAFA (arrow) was detected using the purified Pab. Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MAFA antibody

MAFA Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MAFA antibody

MAFA Mouse IgG2a 2F1 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MAFA (C-term) antibody

Mouse Muscle; WB Suggested Anti-Mafa Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:62500. Positive Control: Mouse Muscle; Mafa antibody - C-terminal region (ARP37614_P050) in Mouse Muscle cells using Western Blot Rabbit Aff - Purified Ms WB
50 µg / €350.00
  AVIVA Systems Biology

MAFA (Center) antibody

Mouse Kidney; WB Suggested Anti-Mafa Antibody Titration: 0.2-1 ug/ml. Positive Control: Mouse Kidney; Mafa antibody - middle region (ARP37615_P050) in Mouse Kidney cells using Western Blot Rabbit Aff - Purified Ms WB
50 µg / €350.00
  AVIVA Systems Biology

MAFA (N-term) antibody

Human Placenta; WB Suggested Anti-MAFA Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Placenta; MAFA antibody - N-terminal region (ARP47760_P050) in Human Placenta cells using Western Blot Rabbit Aff - Purified Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

MAFA antibody

Human Thymus; WB Suggested Anti-MAFA Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: Human Thymus; MAFA antibody - N-terminal region (ARP47762_P050) in Human Thymus cells using Western Blot Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MAFA

MAFA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MAFA

MAFA Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MAFA overexpression lysate

MAFA overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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