Major Vault Protein antibody

Principal name

Major Vault Protein antibody

Alternative names for Major Vault Protein antibody

MVP, LRP, Lung-Resistance Related Protein

SwissProt ID

Q14764 (Human), Q3SYU9 (Bovin), Q5ZMI4 (Chick), Q62667 (Rat), Q9EQK5 (Mouse)

Gene ID

9961 (MVP)

Available reactivities

Hu (Human), Rt (Rat), Ms (Mouse), Bov (Bovine), Ze (Zebrafish), African clawed frog, Fi (Fish), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Mouse, Rat, Rabbit

Available applications

Frozen Sections (C), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Immunoprecipitation (IP)

Background of Major Vault Protein antibody

MVP is identical to lung-resistance related protein (LRP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Amino acid 241-280 of human estrogen receptor (ER), (site of nuclear localization signal sequence), is mapped to be the site of interaction between ER and MVP. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. Anti-estrogen 1C1182 shows no effect. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to progesterone and glucocorticoid receptors are also able to co-immunoprecipitate the MVP. LRP is a protein overexpressed in many neoplastic tissues and cell lines. Expression of LRP predicts a poor response to chemotherapy.
This 104-kD protein is the major vault protein (MVP) also described as the lung resistance protein (LRP) and has shown to interact with the estrogen receptor. The protein is part of a very large vault ribonucleoprotein complex present in all eukaryotic cells and its structure and protein composition is highly conserved. Because of the size, shape, and protein and RNA composition of this complex the particles are different from other ribonucleoproteins.

General readings

General / background references:Abbondanza C et al. Interaction of vault particles with estrogen receptor in the MCF-7 breast cancer cell. J Cell Biol 141:1301-10 (1998). PubMed PMID: 9628887

  1. Quick-Filters:
  2. Highly Validated (2)

Items 1 to 20 of 31 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Major Vault Protein antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 7.5% SDS PAGE. TA308784 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

Immunoperoxidase of monoclonal antibody to MVP on formalin-fixed paraffin-embedded human lung, adenosqumous cell carcinoma. [antibody concentration 3ug/ml] Mouse IgG2a 2H3-1A6 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

Major Vault Protein (C-term) antibody

The anti-MVP C-term Antibody (Cat.#TA302181) is used in Western blot to detect MVP in A375 lysate. Rabbit Ig Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Major Vault Protein (878-893) antibody

Anti-MVP antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml. Rabbit Purified Hu E, P
50 µg / €345.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

Predicted band size: 99 kDa . Positive control: 823 cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 50 ug Primary antibody: 1/350 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

Predicted band size: 99 kDa . Positive control: 231 cell and mouse kidney tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: 231 cell lysate Lane2: Mouse kidney tissue lysate Lysates: 50 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 second) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

Western blot analysis of extracts of various cell lines, using MVP antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

WB Suggested Anti-MVP Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:1562500; Positive Control: COLO205 cell lysate Rabbit IgG Purified Bov, Eq, GP, Hu, Ms, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

Major Vault Protein antibody

Major Vault Protein Mouse IgM 1032 Purified Hu C, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgM 1027 Purified Hu C, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgG1 1014 Purified Hu C, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgG1 1011 Purified Hu C, WB
0.1 mg / €300.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgG2b MVP-37 Supernatant Hu C, P, WB
1 ml / €420.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Rat IgG LMR5 Liquid Hu C, P
1 ml / €420.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgG2b LRP-56 Supernatant Hu C, ICC/IF, P
1 ml / €420.00
  Acris Antibodies GmbH

Major Vault Protein (N-term) antibody

Western blot analysis of anti-MVP Pab in mouse kidney tissue lysate (35ug/lane). MVP(arrow) was detected using the purified Pab (1:60 dilution). Rabbit Ig Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Major Vault Protein Mouse IgG2b LRP56 Supernatant Hu C, F, P
0.5 ml / €480.00
  Acris Antibodies GmbH

Major Vault Protein antibody

Immunohistochemical staining using MVP monoclonal antibody, clone 1032 ( Cat # MAB1945 ) on formalin fixed, paraffin embedded human breast carcinoma. Hu, Rt
0.1 mg / €640.00
  Abnova Taiwan Corp.

Major Vault Protein antibody

Major Vault Protein Rat IgG LMR5 Hu C, F, P
0.5 ml / €640.00
  Abnova Taiwan Corp.

Major Vault Protein antibody

Major Vault Protein Mouse IgG1 1014 Hu C, WB
0.1 mg / €640.00
  Abnova Taiwan Corp.

Items 1 to 20 of 31 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn