Malcavernin antibody

Principal name

Malcavernin antibody

Alternative names for Malcavernin antibody

CCM2, C7orf22, PP10187, Cerebral cavernous malformations 2 protein

SwissProt ID

Q8K2Y9 (Mouse), Q9BSQ5 (Human)

Gene ID

83605 (CCM2), 216527 (Ccm2)

Available reactivities

Hu (Human), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of Malcavernin antibody

Cerebral cavernous malformations (CCMs) are sporadically acquired or inherited vascular lesions of the central nervous system consisting of clusters of dilated thin-walled blood vessels that predispose individuals to seizures and stroke. Familial CCM is caused by mutations in KRIT1 (CCM1) or in malcavernin (CCM2). The roles of the CCM proteins in the pathogenesis of the disorder remain largely unknown. It was shown that the CCM1 gene product, KRIT1, interacts with the CCM2 gene product, malcavernin. Analogous to the established interactions of CCM1 and beta1 integrin with ICAP1, the CCM1/CCM2 association is dependent upon the phosphotyrosine binding (PTB) domain of CCM2. A familial CCM2 missense mutation abrogates the CCM1/CCM2 interaction, suggesting that loss of this interaction may be critical in CCM pathogenesis. CCM2 and ICAP1 bound to CCM1 via their respective PTB domains differentially influence the subcellular localization of CCM1. The data indicate that the genetic heterogeneity observed in familial CCM may reflect mutation of different molecular members of a coordinated signaling complex.
The CCM-2 is fused to a N-terminal His-tag (6x His).

General readings

Dupre N. et al. (2003) Can J Neurol Sci. 30:122-128
Liquori CL. et al. (2007) Am J Hum Genet. 80:69-75.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI2F9 (formerly 2F9)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503414) Mouse IgG1 OTI2F9 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI1E9 (formerly 1E9)  
Immunohistochemical staining of paraffin-embedded Human lung tissue within the normal limits using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503417) Mouse IgG1 OTI1E9 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  Goat Polyclonal Antibody against CCM2  
TA303163 (0.03µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI3B7 (formerly 3B7)  
Anti-CCM2 mouse monoclonal antibody (TA503397) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI3B7 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI1E8 (formerly 1E8)  
Anti-CCM2 mouse monoclonal antibody (TA503410) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI1E8 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI2C10 (formerly 2C10)  
Anti-CCM2 mouse monoclonal antibody (TA503413) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI2C10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI2E4 (formerly 2E4)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-CCM2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA503416) Mouse IgG1 OTI2E4 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI5C3 (formerly 5C3)  
Anti-CCM2 mouse monoclonal antibody (TA503418) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI5C3 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI1D1 (formerly 1D1)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CCM2 (RC201418, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CCM2. Mouse IgG2a OTI1D1 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI4F5 (formerly 4F5)  
Anti-CCM2 mouse monoclonal antibody (TA503420) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI4F5 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI1B9 (formerly 1B9)  
Anti-CCM2 mouse monoclonal antibody (TA503461) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG1 OTI1B9 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

  CCM2 mouse monoclonal antibody, clone OTI5H4 (formerly 5H4)  
Anti-CCM2 mouse monoclonal antibody (TA503462) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CCM2(RC201418). Mouse IgG2b OTI5H4 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Malcavernin antibody

Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM2 antibody Cat.-No. AP26022PU (K5546, dilution1/50). A) Note specific staining in the wall of microvessels. B) Negative control of a consecutive section. Note non-specific fluorescence in elastic fibres in the adventitia of anarteriol. 
Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting, Goettingen.
The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany. Rabbit Aff - Purified Hu ICC/IF, WB
0.2 mg / €370.00
  Acris Antibodies GmbH

Malcavernin antibody

Immunofluorescence staining (green) of Human foreskin (cryo-section of unfixed tissue) with anti-Human CCM2 antibody Cat.-No. AP26022PU (K5546, dilution1/50). A) Note specific staining in the wall of microvessels. B) Negative control of a consecutive section. Note non-specific fluorescence in elastic fibres in the adventitia of anarteriol. 
Nuclei counter-stained with Dapi (blue). Specimen provided by Prof. Dr. J. Wilting, Goettingen.
The experiment was performed by the research group of Prof. Dr. J. Wilting, University Göttingen, Germany. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €270.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

CCM2 - human gene knockout kit via CRISPR

CCM2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

CCM2 - human gene knockout kit via CRISPR

CCM2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCM2 - human gene knockout kit via CRISPR

CCM2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

CCM2 - human gene knockout kit via CRISPR

CCM2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Malcavernin (transcript variant 2)

  Recombinant protein of human cerebral cavernous malformation 2 (CCM2), transcript variant 2  
Malcavernin Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

Malcavernin (His-tag)

Malcavernin Human Purified > 95 % by SDS-PAGE and silver stain E. coli
20 µg / €200.00
  Acris Antibodies GmbH

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