Mannan Binding Protein antibody

Principal name

Mannan Binding Protein antibody

Alternative names for Mannan Binding Protein antibody

MBP, Mannose-binding protein C, MBP-C, MBP1, Mannan-binding protein, Mannose-binding lectin, MBL2, MBL

SwissProt ID

O02659 (Bovin), P08661 (Rat), P11226 (Human), P41317 (Mouse)

Gene ID

4153 (MBL2), 17195 (Mbl2), 64668

Available reactivities

Hu (Human), Ms (Mouse), Can (Canine), Mky (Monkey), Rt (Rat), Bov (Bovine), Eq (Equine), Gt (Goat), Por (Porcine), Sh (Sheep), Chimp (Chimpanzee)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Neutralisation (NEUT), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP)

Background of Mannan Binding Protein antibody

Mannose binding lectin (MBL), also called mannose- or mannan-binding protein (MBP), is a member of the group of collectins. MBL is an important pattern-recognition receptor in the innate immune system. The protein mediates innate immune responses, such as activation of the complement lectin pathway and phagocytosis, to help fight infections. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. Binding of MBL leads to the activation of MBL-associated serine proteases (MASP's). Activated MASP-2 cleaves C4 and C2 in a similar way as C1s do for the classical pathway (CP) leading to the formation of C4b2a, cleavage of the classical pathway convertase C3, and eventually complement activation up to the formation of the membrane attack complex. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways.
MBL is predominantly synthesized by hepatocytes and has been isolated from the liver or serum of several vertebrate species. Only one form of human MBL has been characterized, while two forms are found in rhesus monkeys, rabbits, rats and mice. The mouse forms are known as MBL-A and MBL-C.
The MBL-C concentrations in serum are about 6-fold compared to that of MBL-A. MBL-A, but not MBL-C, was found to be an acute phase protein in casein and LPS-injection models. MBL-C exists in higher oligomeric forms than MBL-A.

General readings

Saevarsdottir S, Oskarsson OO, Aspelund T, Eiriksdottir G, Vikingsdottir T, Gudnason V, Valdimarsson H. Mannan binding lectin as an adjunct to risk assessment for myocardial infarction in individuals with enhanced risk. J Exp Med. 2005 Jan 3;201(1):117-25.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Mannan Binding Protein antibody

  MBL2 mouse monoclonal antibody, clone OTI1A12 (formerly 1A12)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-MBL2 mouse monoclonal antibody (TA507147) at 1:150 dilution. Mouse IgG1 OTI1A12 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mannan Binding Protein antibody

  Goat Polyclonal Antibody against MBL2  
TA302979 (1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Chimp, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  Rabbit polyclonal anti-MBL2 antibody  
Western blot analysis of extracts from HepG2 cells and 293 cells, using MBL2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  Rabbit anti-MBL2 Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using MBL2 antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  Rabbit Polyclonal Anti-MBL2 Antibody  
WB Suggested Anti-MBL2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Hela cell lysate Rabbit IgG Purified Bov, Eq, Gt, Hu, Por, Rt, Sh WB
50 µg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  Mouse monoclonal Anti-MBP Clone TVG MBP 3  
Mannan Binding Protein Mouse IgM TVG MBP 3 Purified E, IP, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  Mouse monoclonal Anti-MBP Clone R3.2  
Mannan Binding Protein Mouse IgG2 R3.2 Purified IP, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

  MBL2 mouse monoclonal antibody, clone OTI2G5 (formerly 2G5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MBL2 (RC210143, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MBL2. Mouse IgG1 OTI2G5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mannan Binding Protein antibody

  Rabbit Polyclonal Mannose Binding Lectin Antibody  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MBL2 (RC210143, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MBL2. Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mannan Binding Protein antibody

MBL-C (clone 14D12) deposition in developing murine atherosclerotic lesions following 10 weeks of high fat feeding. MBL-C was detected in and around invading macrophages invading the intima (insert). MBL-C bound, similar to MBL-A, at sites of necrosis (upper right corner). No MBL-C binding was shown in the media or on fibrous caps covering the thickened intima. Rat IgG2a 14D12 Purified Ms C, E, ICC/IF, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Mannan Binding Protein antibody

Mannan Binding Protein Rat IgG2a 16A8 Purified Ms E, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

Mannan Binding Protein antibody

Mannan Binding Protein Mouse IgG1 3E7 Liquid Hu C, E, NEUT, WB
0.1 mg / €710.00
  Acris Antibodies GmbH

Mannan Binding Protein antibody

Mannan Binding Protein Mouse IgG1 D8.18 Biotin Hu F, WB
50 µg / €340.00
  Acris Antibodies GmbH

Mannan Binding Protein antibody

Mannan Binding Protein Mouse IgG1 D8.18 Purified Hu E, F, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MBL2 - human gene knockout kit via CRISPR

MBL2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MBL2 - human gene knockout kit via CRISPR

MBL2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MBL2 - human gene knockout kit via CRISPR

MBL2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MBL2 - human gene knockout kit via CRISPR

MBL2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbl2 - mouse gene knockout kit via CRISPR

Mbl2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mbl2 - mouse gene knockout kit via CRISPR

Mbl2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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