MAP-1A antibody

Principal name

MAP-1A antibody

Alternative names for MAP-1A antibody

Microtubule-associated protein 1A, MAP1A, MAP1L

SwissProt ID

P34926 (Rat), P78559 (Human), Q9QYR6 (Mouse)

Gene ID

25152 (Map1a), 4130 (MAP1A)

Available reactivities

Ms (Mouse), Rt (Rat), Hu (Human)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP)

Background of MAP-1A antibody

Microtubules are the ubiquitous cytoskeletal structural components that are involved in intracellular transport. They are composed of tubulin and microtubule-associated proteins (MAPs). There is considerable evidence that MAPs may mediate the binding of membranous organelles, actin filaments and intermediate filaments to microtubules, leading to the speculation that they may therefore be important for cellular processes such as mitosis and organelle transport, and for determining the dynamic properties of the cytoskeleton. Two classes of high molecular weight components termed MAP1 and MAP2 have been demonstrated to co-purify with tubulin during cycles of microtubule assembly and disassembly, and to stimulate microtubule assembly in vitro. MAP1 is one of the major neuronal MAPs as well as being the largest (350 kD). Purified preparations of MAP1 from bovine brain have been demonstrated to contain at least two low molecualr weight components (19-34 kD) that remain tightly associated with MAP1 heavy chains under nondenaturing conditions. In contrast to MAP2 which is localized primarily in the dendrites of neurons in brain and possibly in small amounts in other cells, MAP1 is more generally distributed, being found in both dendrites and axons of neurons and in glial cells in brain, in chromtophores, and on both interphase and mitotic microtubules in various tissue culture cells, suggesting that MAP1 may have a more general function. In the newborn rat brain the expression of MAP1 is almost absent. Its levels begin to increase from postnatal day 5 and increase steadily, in step with neuronal differentiation, reaching a maximum around postnatal day 28, the time when neurons have reached their mature morphology. MAP1 is degraded by a Cathepsin D like protease in the brain of aged rats. In developmental neurobiology MAP1 acts as a marker of neuronal maturation.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAP-1A antibody

Predicted cell location: Nucleus,Cytoplasm. Positive control: Human thyroid and lung cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using MAP1A antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP-1A antibody

Predicted cell location: Nucleus,Cytoplasm. Positive control: Human thyroid and ovarian cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using MAP1A antibody at dilution 1/25, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP-1A antibody

MAP-1A Mouse IgG1 MP-1 Purified Rt C, P, WB
0.1 mg / €340.00
  Acris Antibodies GmbH

MAP-1A antibody

MAP-1A Mouse IgG1 MP-1 Rt C, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MAP-1A antibody

MAP-1A Mouse IgG1 MP-1 Ascites Rt C, P, WB
0.1 mg / €290.00
  Boster Immunoleader

MAP-1A antibody

Western Blot: MAP1A Antibody [NB100-68254] - Detection of Human MAP1A by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-MAP1A antibody NB100-68254 used for IP at 3  mcg/mg lysate. MAP1A was also immunoprecipitated by rabbit  anti-MAP1A antibody NB100-68255, which recognizes a  downstream epitope.   Detection: Chemiluminescence with an exposure time of 10  seconds. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MAP-1A antibody

Western Blot: MAP1A Antibody [NB100-68255] - Detection of Human MAP1A by Western Blot of  Immunoprecipitates. Samples: Whole cell lysate (1 mg for IP,  20% of IP loaded) from HeLa cells. Antibodies: Affinity purified  rabbit anti-MAP1A antibody NB100-68255 used for IP at 3  mcg/mg lysate. MAP1A was also immunoprecipitated by rabbit  anti-MAP1A antibody NB100-68254, which recognizes an  upstream epitope.   Detection: Chemiluminescence with an exposure time of 10  seconds. Rabbit IgG Aff - Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MAP-1A antibody

MAP-1A Mouse IgG1 HM-1 Ascites Ms, Rt C, P, WB
0.1 ml / €510.00
  Novus Biologicals Inc.

8 Item(s)

per page
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