MAP1LC3C antibody

Principal name

MAP1LC3C antibody

Alternative names for MAP1LC3C antibody

Microtubule-associated protein 1 LC3 gamma, MAP1A/1B light chain 3 C, MAP1A/MAP1B LC3 C, MAP1 light chain 3-like protein 3, Autophagy-related protein LC3 C, Autophagy-related ubiquitin-like modifier LC3 C, Microtubule-associated proteins 1A/1B light chain 3C

SwissProt ID

Q9BXW4 (Human)

Gene ID

440738 (MAP1LC3C)

Available reactivities

Hu (Human), Mky (Monkey), Prim (Primate), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Goat, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E)

Background of MAP1LC3C antibody

Macroautophagy is the major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane bound autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane bound structure, which then fuse with the lysosome (or vacuole) releasing a single-membrane bound autophagic bodies which are then degraded within the lysosome (or vacuole). MAP1A and MAP1B are microtubule-associated proteins which mediate the physical interactions between microtubules and components of the cytoskeleton. These proteins are involved in formation of autophagosomal vacuoles (autophagosomes). MAP1A and MAP1B each consist of a heavy chain subunit and multiple light chain subunits. MAP1LC3c is one of the light chain subunits and can associate with either MAP1A or MAP1B. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

General readings

1. Liao G, Cheung S, Galeano J, Ji AX, Qin Q, Bi X. Allopregnanolone treatment delays cholesterol accumulation and reduces autophagic/lysosomal dysfunction and inflammation in Npc1-/- mouse brain. Brain Res. 2009 May 13;1270:140-51. doi: 10.1016/j.brainres.2009.03.027. Epub 2009 Mar 25. PubMed PMID: 19328188.
2. Thyagarajan A, Jedinak A, Nguyen H, Terry C, Baldridge LA, Jiang J, et al. Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK). Nutr Cancer. 2010;62(5):630-40. doi: 10.1080/01635580903532390. PubMed PMID: 20574924.
3. Choi KC, Kim SH, Ha JY, Kim ST, Son JH. A novel mTOR activating protein protects dopamine neurons against oxidative stress by repressing autophagy related cell death. J Neurochem. 2010 Jan;112(2):366-76. doi: 10.1111/j.1471-4159.2009.06463.x. Epub 2009 Oct 29. PubMed PMID: 19878437.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAP1LC3C antibody

  Rabbit Polyclonal MAP1LC3C Antibody  
Western blot analysis of MAP1LC3C in human brain tissue lysate with MAP1LC3C antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAP1LC3C antibody

  Rabbit Polyclonal Anti-MAP1LC3C Antibody  
MAP1LC3C Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP1LC3C (N-term) antibody

LC3C Antibody (APG8c) Cat.-No AP32196PU-N iss used in Western blot to detect LC3 (APG8c) in, from left to right, 293, Ramos, Hela, HepG2, T47d, and Jurkat tissue lysates. LC3 (APG8c)(arrow) was detected using the purified Pab. Rabbit Ig Purified Hu, Ms, Rt P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MAP1LC3C - human gene knockout kit via CRISPR

MAP1LC3C - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MAP1LC3C - human gene knockout kit via CRISPR

MAP1LC3C - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MAP1LC3C - human gene knockout kit via CRISPR

MAP1LC3C - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MAP1LC3C - human gene knockout kit via CRISPR

MAP1LC3C - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MAP1LC3C overexpression lysate

MAP1LC3C overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

8 Item(s)

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