MAP2K7 antibody

Principal name

MAP2K7 antibody

Alternative names for MAP2K7 antibody

MAPK/ERK kinase 7, JNK-activating kinase 2, c-Jun N-terminal kinase kinase 2, MAPKK 7, NKK2, MEK7, MKK7, MAP kinase kinase 7, Dual specificity mitogen-activated protein kinase kinase 7

SwissProt ID

O14733 (Human), Q4KSH7 (Rat), Q8CE90 (Mouse)

Gene ID

5609 (MAP2K7), 26400 (Map2k7), 363855

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of MAP2K7 antibody

MAP2K7(Mitogen-activated protein kinase kinase 7), also known as MAP kinase kinase 7, MAPKK7, JNKK2, PRKMK7 or MKK7, is an enzyme that in humans is encoded by the MAP2K7 gene. This protein is a member of the mitogen-activated protein kinase kinase family. The MKK7 protein exists as six different isoforms with three possible N-termini (alpha, beta, and gamma isoforms) and two possible C-termini (1 and 2 isoforms). Schramek et al. (2011) showed that the doxorubicin-mediated DNA damage response in human A549 lung carcinoma cells caused rapid phosphorylation and upregulation of p53 (TP53). MKK7 knockdown reduced p53 phosphorylation, delayed p53 upregulation, and interfered with cell cycle arrest at G2/M. MKK7 was activated in primary lung tumors, and tumors with a p53 mutation showed even higher MKK7 phosphorylation. Schramek et al. (2011) concluded that MKK7 exerts its tumor suppressive function through p53.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAP2K7 antibody

  MAP2K7 Rabbit Polyclonal Antibody  
Western blot analysis of extracts of various celllines, using MAP2K7 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAP2K7 antibody

Immunohistochemical analysis of paraffin-embedded lung cancer tissues using MAP2K7 mouse mAb with DAB staining. Mouse IgG1 4E5 Ascites Hu E, F, ICC/IF, P, WB
0.1 ml / €430.00
  Acris Antibodies GmbH

MAP2K7 antibody

  Rabbit polyclonal MAP2K7 (Ser271) antibody(Phospho-specific)  
Western blot analysis of extracts from 3T3 cells treated with insulin (0.01U/ml, 15mins) and 3T3 cells treated with EGF (200ng/ml, 30mins), using MAP2K7 (Phospho-Ser271) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP2K7 antibody

  Rabbit polyclonal MAP2K7 (Thr275) antibody(Phospho-specific)  
Western blot analysis of extracts from HeLa cells, treated with calyculinA (50ng/ml, 30mins), using MAP2K7 (Phospho-Thr275) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP2K7 (incl. pos. control) antibody

Detection of endogenous MKK7: Whole cell lysates of serum starved tumor cells (20.000 cells per lane) were applied to SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with mab MKK7-10F7 (0.5 µg/ ml) for 1h at RT and developed by ECL (exp. time: 30 sec). lane 1: A431; lane 2: A549; lane 3: SKOV3; lane 4: OVCAR5; lane 5: HaCaT; lane 6: PC3; lane 7: HeLa; lane 8: HepG2 Mouse IgG1 10F7 Purified Can, Hu, Ms, Rt C, E, ICC/IF, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

MAP2K7 antibody

Western blot (WB) analysis of MEK-7 antibody (Cat.-No.: AP21117PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MAP2K7 pSer271 antibody

Immunohistochemical analysis of paraffin-embedded humanbrain tissue, using MAP2K7 (Phospho-Ser271) antibody AP55764PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €340.00
  Acris Antibodies GmbH

MAP2K7 pSer271 antibody

Immunohistochemical analysis of paraffin-embedded humanbrain tissue, using MAP2K7 (Phospho-Ser271) antibody AP55764PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €270.00
  Acris Antibodies GmbH

MAP2K7 pThr275 antibody

Western blot analysis of extracts from cos-7 cells (Lane 2) and 3T3 cells (Lane 3), using MAP2K7 (Phospho-Thr275) Antibody AP55765PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH

MAP2K7 pThr275 antibody

Western blot analysis of extracts from cos-7 cells (Lane 2) and 3T3 cells (Lane 3), using MAP2K7 (Phospho-Thr275) Antibody AP55765PU-N. The lane on the left is treated with antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH

MAP2K7 pSer271 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using MAP2K7 (Phospho-Ser271) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

MAP2K7 pSer271 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using MAP2K7 (Phospho-Ser271) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

MAP2K7 pThr275 antibody

Western blot analysis of extracts from HeLa cells treated with calyculinA 50ng/ml 30', using MAP2K7 (Phospho-Thr275) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

MAP2K7 pThr275 antibody

Western blot analysis of extracts from HeLa cells treated with calyculinA 50ng/ml 30', using MAP2K7 (Phospho-Thr275) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

MAP2K7 antibody

Western blot analysis of extracts from NIH-3T3 cells, using MAP2K7 (Ab-271) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

MAP2K7 antibody

Western blot analysis of extracts from NIH-3T3 cells, using MAP2K7 (Ab-271) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Map2k7 - mouse gene knockout kit via CRISPR

Map2k7 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Map2k7 - mouse gene knockout kit via CRISPR

Map2k7 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Map2k7 - mouse gene knockout kit via CRISPR

Map2k7 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Map2k7 - mouse gene knockout kit via CRISPR

Map2k7 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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