MAP3K4 antibody

Principal name

MAP3K4 antibody

Alternative names for MAP3K4 antibody

MAPK/ERK kinase kinase 4, MAP three kinase 1, MAPKKK4, MEKK4, MTK1, Mitogen-activated protein kinase kinase kinase 4

SwissProt ID

O08648 (Mouse), Q9Y6R4 (Human)

Gene ID

4216 (MAP3K4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of MAP3K4 antibody

The central core of each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase kinase (MAPKKK) phosphorylates and activates a specific MAPK kinase (MAPKK), which then activates a specific MAPK. While the ERK MAPKs are activated by mitogenic stimulation, the CSBP2 and JNK MAPKs are activated by environmental stresses such as osmotic shock, UV irradiation, wound stress, and inflammatory factors. This gene encodes a MAPKKK, the MEKK4 protein, also called MTK1. This protein contains a protein kinase catalytic domain at the C terminus. The N-terminal nonkinase domain may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 and JNK MAPK pathways, but not the ERK pathway. In vitro kinase studies indicated that recombinant MEKK4 can specifically phosphorylate and activate PRKMK6 and SERK1, MAPKKs that activate CSBP2 and JNK, respectively but cannot phosphorylate PRKMK1, an MAPKK that activates ERKs. MEKK4 is a major mediator of environmental stresses that activate the CSBP2 MAPK pathway, and a minor mediator of the JNK pathway. Two alternatively spliced transcripts encoding distinct isoforms have been described.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAP3K4 antibody

  Rabbit polyclonal anti-MAP3K4 antibody  
Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MAP3K4 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP3K4 antibody

  Anti-MAP3K4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and ovarian cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using MAP3K4 antibody at dilution 1/40, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP3K4 antibody

  Anti-MAP3K4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm. Positive control: Human thyroid and breast cancer tissue . Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human thyroid cancer tissue using MAP3K4 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAP3K4 (Center) antibody

Formalin fixed and paraffin embedded human heart stained with MEKK4 Antibody (Center) Cat.-No AP52665PU-N tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MAP3K4 antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MAP3K4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
50 µg / €230.00
  Assay Biotech

MAP3K4 antibody

Immunohistochemistry analysis of paraffin-embedded human heart tissue, using MAP3K4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, P
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

MAP3K4 - human gene knockout kit via CRISPR

MAP3K4 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MAP3K4 (mGFP-tagged)-Human mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MAP3K4 (mGFP-tagged)-Human mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,320.00
  OriGene Technologies, Inc.

Lenti ORF particles, MAP3K4 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MAP3K4 (Myc-DDK-tagged)-Human mitogen-activated protein kinase kinase kinase 4 (MAP3K4), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €1,180.00
  OriGene Technologies, Inc.

9 Item(s)

per page
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