MAPK8 / JNK1 antibody

Principal name

MAPK8 / JNK1 antibody

Alternative names for MAPK8 / JNK1 antibody

Mitogen-activated protein kinase 8, c-Jun N-terminal kinase 1, JNK-46, JNK-1, PRKM8, Stress-activated protein kinase JNK1

SwissProt ID

P45983 (Human), P49185 (Rat), Q8QHK8 (Xenla), Q8WQG9 (Caeel), Q91Y86 (Mouse)

Gene ID

5599 (MAPK8), 26419 (Mapk8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Can (Canine), Bov (Bovine), Chk (Chicken), Por (Porcine), Ce (C. elegans), Mam (Mammalia)

Available hosts

Rabbit, Mouse

Available applications

Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot)

Background of MAPK8 / JNK1 antibody

Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as JUN, JDP2 and ATF2 and thus regulates AP-1 transcriptiol activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells By similarity. Phosphorylates heat shock factor protein 4 (HSF4). /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptiol activity. In T-cells, JNK1 and JNK2 are required for polarized differentiation of T-helper cells into Th1 cells. JNK2 isoforms display different binding patterns: a-1 and a-2 preferentially bind to c-Jun, whereas beta-1 and beta-2 bind to ATF2. However, there is no correlation between binding and phosphorylation, which is achieved at about the same efficiency by all isoforms. JUNB is not a substrate for JNK2 a-2, and JUND binds only weakly to it. /Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, primarily components of AP-1 such as c-Jun and ATF2 and thus regulates AP-1 transcriptiol activity. Required for stress-induced neurol apoptosis and the pathogenesis of glutamate excitotoxicity

General readings

Dasgupta, J., et al. J. Cell. Physiol. 225(1):52-62(2010)
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Gao, D., et al. J. Biol. Chem. 285(39):29965-29973(2010)
Han, J.S., et al. Anticancer Res. 30(9):3407-3412(2010)
Yang, X.H., et al. World J. Gastroenterol. 16(27):3385-3393(2010)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

JNK1/2 pThr183/pTyr185 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (#AP09471PU, Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

JNK1/2 pThr183/pTyr185 antibody

Figure 1. Immunofluorescence staining of methanol-fixed HeLa cells using JNK1/JNK2 (phospho-Thr183/Tyr185) Antibody (#AP09471PU, Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

JNK1/2/3 pThr183 antibody

Immunohistochemistry (IHC) analyzes of p-JNK1/2/3 antibody (Cat.-No.: AP20849PU-N) in paraffin-embedded human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

JNK1/2/3 pThr183 antibody

Immunohistochemical analysis of JNK1/2/3 (pT183) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt ICC/IF, P, WB
30 µl / €210.00
  Cohesion Biosciences Ltd.

JNK1/2/3 pThr183 antibody

Immunohistochemical analysis of JNK1/2/3 (pT183) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt ICC/IF, P, WB
0.1 ml / €330.00
  Cohesion Biosciences Ltd.

JNK1/2/3 pThr183 antibody

Immunohistochemical analysis of JNK1/2/3 (pT183) staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Bov, Chk, Hu, Ms, Por, Rt ICC/IF, P, WB
0.2 ml / €530.00
  Cohesion Biosciences Ltd.

MAPK8 / JNK1 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAPK8 (RC218407, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MAPK8. Mouse IgG2a OTI2F10 Purified Hu WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MAPK8 / JNK1 antibody

Anti-JNK1 mouse monoclonal antibody (TA500043) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY JNK1(RC218407). Mouse IgG2a OTI1C2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MAPK8 / JNK1 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-JNK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500075) Mouse IgG1 OTI2C6 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MAPK8 / JNK1 antibody

Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-JNK1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500081) Mouse IgG2a OTI4E3 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MAPK8 / JNK1 antibody

Western blot analysis using MAPK8 antibody Cat.-No AM06773PU-N against human MAPK8 (AA: 227-380) recombinant protein. Mouse IgG1 1E5 Purified Hu, Ms E, WB
0.1 mg / €430.00
  Acris Antibodies GmbH

MAPK8 / JNK1 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 1A2 Purified Hu E, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

MAPK8 / JNK1 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 4H6 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

MAPK8 / JNK1 antibody

Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2b 4H5 Purified Hu E, IP, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

MAPK8 / JNK1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between MAPK8 and FASLG. HeLa cells were stained with anti-MAPK8 rabbit purified polyclonal 1:1200 and anti-FASLG mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MAPK8 / JNK1 antibody

Proximity Ligation Analysis (PLA) of protein-protein interactions between BAD and MAPK8 Mahlavu cells were stained with anti-BAD rabbit purified polyclonal 1:1200 and anti-MAPK8 mouse monoclonal antibody 1:50. Signals were detected by Duolink® 30 Detection Kit 613(red), and nuclei were counterstained with DAPI (blue). Each red dot represents the detection of protein-protein interaction complex. Mouse IgG2a 2F11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MAPK8 / JNK1 antibody

Sample (30 ug of whole cell lysate). A: Raji. 10% SDS PAGE. TA308811 diluted at 1:1000. Rabbit IgG Aff - Purified Hu, Ms ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPK8 / JNK1 antibody

Western blot analysis of extracts from 293 cells, treated with UV (5mins), using JNK1/2/3 (Phospho-Thr183+Tyr185) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPK8 / JNK1 antibody

Predicted band size: 48 kDa . Positive control: Human lymphoma and liver cancer tissue lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lane1: Human lymphoma tissue lysate Lane2: Human liver cancer tissue lysate Lysates: 40 ug per lane Primary antibody: 1/1000 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 5 minutes) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPK8 / JNK1 antibody

Western blot analysis of Human lymphoma tissue using TA324295(MAPK8 Antibody) at dilution 1/400 Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

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