MAPK9 / JNK2 antibody

Principal name

MAPK9 / JNK2 antibody

Alternative names for MAPK9 / JNK2 antibody

JNK-55, PRKM9, MAP kinase 9, Mitogen-activated protein kinase 9, Stress-activated protein kinase JNK2, c-Jun N-terminal kinase 2

SwissProt ID

P45984 (Human), P49186 (Rat), P79996 (Chick), Q9WTU6 (Mouse), Q9WTU6-2

Gene ID

5601 (MAPK9), 50658 (Mapk9), 26420

Available reactivities

Can (Canine), Hu (Human), Ms (Mouse), Rt (Rat), Bt (Bat), Bov (Bovine), Eq (Equine), Hst (Hamster), Mky (Monkey), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear, GP (Guinea Pig), Ze (Zebrafish)

Available hosts

Mouse, Rabbit, Goat

Available applications

Frozen Sections (C), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), ELISA (detection) (E(detection))

Background of MAPK9 / JNK2 antibody

The stress-activated protein kise/Jun-amino-termil kise SAPK/JNK is potently and preferentially activated by a variety of environmental stresses including UV and gamma radiation, ceramides, inflammatory cytokines, and in some instances, growth factors and GPCR agonists. As with the other MAPKs, the core sigling unit is composed of a MAPKKK, typically MEKK1-MEKK4, or by one of the mixed lineage kises (MLKs), which phosphorylate and activate MKK4/7. Upon activation, MKKs phosphorylate and activate the SAPK/JNK kise. Stress sigls are delivered to this cascade by small GTPases of the Rho family (Rac, Rho, cdc42). Both Rac1 and cdc42 mediate the stimulation of MEKKs and MLKs. Altertively, MKK4/7 can be activated in a GTPase-independent mechanism via stimulation of a germil center kise (GCK) family member. There are three SAPK/JNK genes each of which undergoes altertive splicing, resulting in numerous isoforms. SAPK/JNK, when active as a dimer, can translocate to the nucleus and regulate transcription through its effects on c-Jun, ATF-2, and other transcription factors.

General readings

Kyriakis J M., et al. (1999) J Biol Chem. 274: 5259-62Whitmarsh., et al. (1998) Trends Biochem Sci. 23: 481-5.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAPK9 / JNK2 antibody

  Rabbit Polyclonal Anti-MAPK9 Antibody - N-terminal region  
WB Suggested Anti-Mapk9 Antibody; Titration: 1.0 ug/ml; Positive Control: Mouse Heart Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €360.00
  OriGene Technologies, Inc.

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