MAPT / TAU antibody

Principal name

MAPT / TAU antibody

Alternative names for MAPT / TAU antibody

MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein, Paired helical filament-tau

SwissProt ID

P10636 (Human), P10636-8, P10637 (Mouse), P19332 (Rat), P29172 (Bovin), Q32KT2 (Bovin), Q5CZI7 (Human)

Gene ID

281296 (MAPT), 4137

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Mky (Monkey), Chk (Chicken), Sh (Sheep), Can (Canine), Rb (Rabbit), Ze (Zebrafish), Por (Porcine)

Available hosts

Rabbit, Goat, Mouse, Chicken, Sheep

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Immunoprecipitation (IP), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of MAPT / TAU antibody

Tau is a relatively low molecular weight member of the microtubule associated protein or MAP family. Most of these proteins were discovered since microtubules can be polymerized in cell homogetes and pelleted out by centrifugation, typically taking MAP proteins with them. This early work showed that the Tau protein facilitated the polymerization of microtubules, and was therefore med after the Greek letter tau, since it promoted tubule formation. Tau is heavily concentrated in axons of neurons, but may also be found in dendrites and in some non-neurol cells. Much interest has focused on Tau as it is a major component of the neurofibrillary tangles of Alzheimer's disease. Tau in neurofibrillary tangles is typically heavily and aberrantly phosphorylated, and it is believed that phosphorylation may be involved in tangle formation. In addition, numerous different point mutations in the Tau gene are causative of Frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17). There is one mammalian Tau gene which produces at least 9 different proteins by alterte transcription. In the central nervous system 6 isoforms predomint which either include or do not include three short exon coded inserts. These proteins range in size from 352-441 amino acids and run on SDS-PAGE gels as multiple bands ranging from 48-67 kDa. In peripheral nervous system a form called "big tau" predomites, another alterte transcript which includes a 254 amino acid insert. This form of Tau is found in small amounts in the brain also, in cranial nerve motor nuclei and sensory processes of most sensory ganglia, and runs on SDS-PAGE with an apparent molecular weight of 100 kDa. Each Tau protein contains 3 or 4 copies of an 18 amino acid peptide which are responsible for binding to the microtubules and are similar to those found in MAP2 and other members of the MAP family. Tau is a highly charged acidic protein with few hydrophobic residues which belongs to the family of "intrinsically unstructured proteins". As with GAP43, MARCKS and several other similar proteins, Tau isoforms run on SDS-PAGE much more slowly than expected from their actual molecular weight. This antibody was made against a recombint construct expressed in and purified from E. coli and which corresponded to the shortest version of the various Tau proteins, so this antibody is expected to bind to all Tau isoforms.

General readings

1. Bihaqi SW & Zawia NH Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb). Neurotoxicology 39:95-101 (2013). WB ; Non Human Primates .PubMed: 23973560
2. Ding Y  et al. Retinoic acid attenuates beta-amyloid deposition and rescues memory deficits in an Alzheimer's disease transgenic mouse model. J Neurosci 28:11622-34 (2008).PubMed: 18987198

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAPT / TAU pSer396 antibody

Immunohistochemical analysis of Paraffin-Embedded Rat Hippocampal region tissue from model with Alzheimer's Disease using Tau antibody pSer396 (AP02394PU-N or AP02394PU-S) Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

MAPT / TAU pSer396 antibody

Immunohistochemical analysis of Paraffin-Embedded Rat Hippocampal region tissue from model with Alzheimer's Disease using Tau antibody pSer396 (AP02394PU-N or AP02394PU-S) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €240.00
  Acris Antibodies GmbH

MAPT / TAU pSer262 antibody

Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer's Disease using Tau (phospho-Ser262) antibody (AP02403PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

MAPT / TAU pSer262 antibody

Immunohistochemical analysis of paraffin-embedded rat hippocampal region tissue from a model with Alzheimer's Disease using Tau (phospho-Ser262) antibody (AP02403PU). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

Human breast carcinoma stained with Neuronal Marker anti-Tau Antibody Cat.-No AM09107PU (Clone SP70). Rabbit IgG SP70 Purified Hu F, P
0.5 ml / €520.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

Human breast carcinoma stained with Neuronal Marker anti-Tau Antibody Cat.-No AM09107PU (Clone SP70). Rabbit IgG SP70 Purified Hu F, P
1 ml / €750.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

Human breast carcinoma stained with Neuronal Marker anti-Tau Antibody Cat.-No AM09107PU (Clone SP70). Rabbit IgG SP70 Purified Hu F, P
0.1 ml / €290.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

AP15811PU Tau antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.5 ml / €360.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

AP15811PU Tau antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
1 ml / €520.00
  Acris Antibodies GmbH

MAPT / TAU (N-term) antibody

AP15811PU Tau antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P
0.1 ml / €190.00
  Acris Antibodies GmbH

MAPT / TAU antibody

Tau antibody detects Tau protein by Western blot analysis. A. 30 ug U87-MG whole cell lysate/extract. B. 30 ug SK-N-SH whole cell lysate/extract. C. 30 ug IMR32 whole cell lysate/extract. D. 30 ug SK-N-AS whole cell lysate/extract. 10 % SDS-PAGE. Tau anti Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western blot analysis of extracts from HeLa/COS7/RAW246.7 cells, using Tau (Ab-235) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western blot analysis of extracts from HeLa cells, using Tau (Ab-396) Antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western blot analysis of extracts from rat brain cells, using Tau (Ab-534/217) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western blot analysis of extracts from rat brain cells, using Tau (Ab-717/400) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU (C-term) antibody

Western blot analysis of TAU(arrow) using rabbit polyclonal TAU Antibody Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western blot analysis of Tau expression in HeLa whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western Blot: Tau Antibody (2E9) [TA337115] - Blots of crude rat brain extract, revealing, as expected, multiple bands in the range 48-67kDa. Mouse IgG1 2E9 Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Western Blot: Tau Antibody [TA337116] - Stripe blot of crude rat brain extract. Tau protein is expressed as up to 9 different isoforms of different molecular weight and so appears as multiple closely spaced bands covering the region of the blot from 48kDa Chicken Purified Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MAPT / TAU antibody

Immunohistochemistry of TAU in mouse brain tissue with TAU antibody at 5 ug/ml. Rabbit IgG Purified Hu, Ms, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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