MARCH8 antibody

Principal name

MARCH8 antibody

Alternative names for MARCH8 antibody

MARCH-VIII, c-MIR, Membrane-associated RING finger protein 8, RNF178, E3 ubiquitin-protein ligase MARCH8, Cellular modulator of immune recognition, RING finger protein 178

SwissProt ID

Q0VD59 (Bovin), Q5T0T0 (Human), Q9DBD2 (Mouse)

Gene ID

220972 (MARCH8)

Available reactivities

Hu (Human), Ms (Mouse), Ze (Zebrafish), Bov (Bovine), Chk (Chicken), Rt (Rat), African clawed frog

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MARCH8 antibody

MARCH8 (c-MIR) is a novel E3 ubiquitin ligase designated as the modulator of immune recognition (MIR) family, whose catalytic domain is a variant RING domain (RING-CH domain). MARCH8 was found as a functional and structural homolog of KSHV MIR1 and MIR2. MARCH8 targets B7-2 to lysosomal degradation and down-regulates the B7-2 surface expression through ubiquitination of its cytoplasmic tail. Furthermore, MARCH8 has been shown to down-regulate the expression of transferrin receptor and Fas, an important molecule for the induction of apoptosis. MARCH8 is the first example of an E3 ubiquitin ligase that is capable of inhibiting MHC II expression. Recent findings suggest that MARCH8 may regulate immune responses by promoting ubiquitination of MHC-II and CD86, leading to their subsequent endocytosis and lysosomal degradation.

  1. Quick-Filters:
  2. Highly Validated (1)

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MARCH8 (C-term) antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu E, ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MARCH8 antibody

Western blot analysis of MARCH8 in HeLa cell lysate with MARCH8 antibody at (A) 0.5 ug/ml and (B) 1 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MARCH8 antibody

WB Suggested Anti-MARCH8 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Human Muscle Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MARCH8 Control Peptide

MARCH8
50 µg / €160.00
  Acris Antibodies GmbH

MARCH8 antibody

MARCH8 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MARCH8 antibody

Human PANC1; WB Suggested Anti-MARCH8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: PANC1 cell lysate. MARCH8 is supported by BioGPS gene expression data to be expressed in PANC1.; MARCH8 antibody - N-terminal region (ARP42958_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MARCH8 antibody

Human NCI-H226; WB Suggested Anti-MARCH8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: NCI-H226 cell lysate; MARCH8 antibody - middle region (ARP42959_P050) in Human NCI-H226 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MARCH8 antibody

Human Muscle; WB Suggested Anti-MARCH8 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:12500. Positive Control: Human Muscle; MARCH8 antibody - middle region (ARP43401_P050) in Human Muscle cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

MARCH8 antibody

Western Blot: MARCH8 Antibody [NBP1-59515] - This Anti-MARCH8 antibody was used in Western Blot of Fetal Muscle tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €440.00
  Novus Biologicals Inc.

MARCH8 antibody

Immunocytochemistry: MARCH8 Antibody [NBP1-76959] - HeLa cells with MARCH8 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

MARCH8 antibody

Immunohistochemistry-Paraffin: MARCH8 Antibody [NBP1-85540] - Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MARCH8 (transcript variant 7)

MARCH8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

MARCH8 (transcript variant 8)

MARCH8 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MARCH8

MARCH8 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MARCH8

MARCH8 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MARCH8

MARCH8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MARCH8

MARCH8 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

17 Item(s)

per page
  • LinkedIn