MARCKS antibody

Principal name

MARCKS antibody

Alternative names for MARCKS antibody

Myristoylated alanine-rich C-kinase substrate, MACS, PRKCSL

SwissProt ID

P12624 (Bovin), P16527 (Chick), P26645 (Mouse), P29966 (Human), P30009 (Rat)

Gene ID

4082 (MARCKS), 25603 (Marcks), 17118

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Xen (Xenopus), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Rat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Background of MARCKS antibody

Actin binding protein MARCKS (myristoylated alanine-rich C kise substrate) is a major substrate of PKC, and alterations in PKC-MARCKS-actin axis are critical to several biological processes such as motility, proliferation, invasion, adhesion, cell spreading phagocytosis, secretion and membrane trafficking. Intracellular MARCKS is normally attached to cytoplasmic face of plasma membrane and when phosphorylated by activated PKC, MARCKS translocates from plasma membrane to cytoplasm. MARCKS regulates cell movement by controlling actin cytoskeleton homeostasis and filopodium/lamellipodium formation. MARCKS binds to F-actin, but not to monomeric G-actin, independently of its phosphorylation status and when unphosphorylated, it induces cell migration. MAPK8 can phosphorylate MARCKS which leads to induction of actin bundles formation/stabilization followed by reduction in actin plasticity and restricted cell movement including neurol/cancer cell migration. MARCKS has also been proposed to be involved in coupling the PKC and calmodulin sigling systems. MARCKS is implicated in the pathogenesis of various maligncies such as cancer of pituitary, thyroid, breast, colon, and small intestine as well as melanoma, glioblastoma multiforme cancer and cholangiocarcinoma.

General readings

1. Rodriguez Peña MJ  et al. MARCKS Protein Is Phosphorylated and Regulates Calcium Mobilization during Human Acrosomal Exocytosis. PLoS One 8:e64551 (2013). WB ; Human . PubMed: 23704996

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MARCKS antibody

Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG1 2C2 Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

MARCKS antibody

Immunoperoxidase of monoclonal antibody to MARCKS on formalin-fixed paraffin-embedded human spleen. [antibody concentration 3 ug/ml] Mouse IgG1 2C2 Purified Hu, Ms E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MARCKS antibody

Western blot of rat cortex lysate showing specific immunolabeling of the ~80k MARCKS protein. Rabbit IgG Serum Rt C, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western blot of rat brain lysate showing specific immunolabeling of the ~87k MARCKS protein phosphorylated at Serr152,156 (Control). The phosphospecificity of this labeling is shown in the second lane (lambda-phosphatase: λ-Ptase). The blot is identical to the control except that it was incubated in λ-Ptase (1200 units for 30 min) before being exposed to the MARCKS  Ser152,156 antibody. The immunolabeling is completely eliminated by treatment with λ-Ptase. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using MARCKS (phospho-Ser162) antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western blot analysis of extracts from K562 cells, treated with EGF (200ng/ml, 30mins), using MARCKS (Phospho-Ser158) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

MARCKS Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

MARCKS Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western blot analysis of extracts from 3T3 cells using Phospho-MARCKS-S158 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western blot analysis of extracts from 293 cells, using Phospho-MARCKS-S162 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western blot analysis of extracts from MCF cells, using phospho-MARCKS-S170 antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

MARCKS antibody

Western Blot: MARCKS Antibody [TA336534] - Western blot of whole rat cortex (Co), cerebellum (Ce), brain stem (BS) and spinal cord (SC) homogenate stained with RPCA-MARCKS, at dilution of 1:10,000. A prominent band running with an apparent SDS-PAGE molecu Rabbit Purified Rt ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARCKS pSer152/156 antibody

MARCKS Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €480.00
  Acris Antibodies GmbH

MARCKS antibody

Western blot (WB) analysis of MARCKS antibody (Cat.-No.: AP01344PU-N) in extracts from mouse brain cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MARCKS pSer158 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using MARCKS pSer158 antibody AP02531PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

MARCKS pSer158 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using MARCKS pSer158 antibody AP02531PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

MARCKS antibody

Western blot analysis of extract from HeLa cells, using MARCKS antibody. Rabbit Aff - Purified Hu, Ms WB
0.1 ml / €270.00
  Acris Antibodies GmbH

MARCKS antibody

Western blot analysis of extract from HeLa cells, using MARCKS antibody. Rabbit Aff - Purified Hu, Ms WB
50 µl / €230.00
  Acris Antibodies GmbH

MARCKS antibody

Immunofluorescence staining of methanol-fixed HeLa cells using MARCKS antibody (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €270.00
  Acris Antibodies GmbH

MARCKS antibody

Immunofluorescence staining of methanol-fixed HeLa cells using MARCKS antibody (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €230.00
  Acris Antibodies GmbH

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