MARK2 antibody

Principal name

MARK2 antibody

Alternative names for MARK2 antibody

Serine/threonine-protein kinase, 2, ELKL motif kinase, EMK1, PAR1 homolog, MARK2, EMK1, MAP/microtubule affinity-regulating kinase

SwissProt ID

O08679 (Rat), Q05512 (Mouse), Q7KZI7 (Human)

Gene ID

2011 (MARK2), 13728 (Mark2), 60328

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MARK2 antibody

MARK2 refers to MAP/microtubule affinity-regulating kinase 2 isoform a [Homo sapiens]. EMK (ELKL Motif Kinase) is a small family of ser/thr protein kinases involved in the control of cell polarity, microtubule
stability and cancer. Several cDNA clones have been isolated that encoded two isoforms of the human ser/thr protein kinase EMK1 called MARK2. These isoforms were characterized by the presence of a 162-bp alternative exon that gave rise to two forms, one containing the exon and the other one lacking it. Both forms were found to be coexpressed in a number of selected cell lines and tissue samples. Human MARK2 was shown to be encoded by a single mRNA ubiquitously expressed. This transcription variant includes the alternative exon in the coding region and therefore codes for a longer protein. Multiple splice variants exist for this protein.
Role in epithelial morphogenesis. Modulates the developmental decision to build a columnar versus a hepatic epithelial cell apparently by promoting a switch from a direct to a transcytotic mode of apical protein delivery. Essential for the asymmetric development of membrane domains of polarized epithelial cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MARK2 antibody

  Goat Polyclonal Antibody against MARK2  
TA303346 (0.3µg/ml) staining of Human Brain (Cerebellum) lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MARK2 antibody

  Rabbit polyclonal anti-MARK2 antibody  
Western blot analysis of extracts from COS-7 cells, using MARK2 antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MARK2 pThr595 antibody

Western blot using Affinity Purified anti-MARK2 pT595 antibody shows detection of a band at ~82 kDa corresponding to phosphorylated MARK2 (arrowhead). HEK293 cells were transfected with pCMV-3xFlag-MARK2 plus pCMV-Flag-PKC-zeta (lane 3) or pCMV-3xFlag-MARK2 only (lane 4). Total cell lysates were run in a 4-12% Nupage SDS-gel and probed with anti-MARK2 pT595. An untransfected HEK293 cell lysate was used as a negative control (lane 2). MW markers are shown for size comparison (lane 1). PKC-zeta appears to be involved in the phosphorylation of T595 on MARK2 as increased amounts of phosphospecific staining are observed in lysates from cells transfected with both MARK2 and PKCzeta. Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, Rt E, WB
0.1 mg / €450.00
  Acris Antibodies GmbH

MARK2 (C-term) antibody

Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. Rabbit Ig Purified Hu, Ms P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MARK2 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MARK2 (Ab-596) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
50 µg / €230.00
  Assay Biotech

MARK2 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using MARK2 (Ab-596) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P
0.1 mg / €330.00
  Assay Biotech

MARK2 antibody

Immunofluorescence analysis of A549 cells, using MARK2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €230.00
  Assay Biotech

MARK2 antibody

Immunofluorescence analysis of A549 cells, using MARK2 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

MARK2 - human gene knockout kit via CRISPR

MARK2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MARK2 - human gene knockout kit via CRISPR

MARK2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MARK2 - human gene knockout kit via CRISPR

MARK2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MARK2 - human gene knockout kit via CRISPR

MARK2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MARK2 (transcript variant 2)

  Recombinant protein of human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 2  
MARK2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MARK2 (full length, N-term HIS tag, transcript variant 1)

  Purified recombinant protein of Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, full length, with N-terminal HIS tag, expressed in E. coli, 50ug  
MARK2 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MARK2 overexpression lysate

MARK2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

MARK2-knockout Cell lysate

MARK2-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MARK2 (mGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MARK2 (mGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,630.00
  OriGene Technologies, Inc.

Lenti ORF particles, MARK2 (mGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 3, 200 uL, >10^7 TU/mL

Lenti ORF particles, MARK2 (mGFP-tagged) - Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 3, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, MARK2 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 4, 200 uL, >10^7 TU/mL

Lenti ORF particles, MARK2 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 4, 200 uL, >10^7 TU/mL  
200 µl / €1,710.00
  OriGene Technologies, Inc.

Lenti ORF particles, MARK2 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 5, 200 uL, >10^7 TU/mL

Lenti ORF particles, MARK2 (mGFP-tagged)-Human MAP/microtubule affinity-regulating kinase 2 (MARK2), transcript variant 5, 200 uL, >10^7 TU/mL  
200 µl / €1,600.00
  OriGene Technologies, Inc.

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