MASP-1 antibody

Principal name

MASP-1 antibody

Alternative names for MASP-1 antibody

Mannose-, Mannan-binding lectin serine protease 1, Complement factor MASP-3, Serine protease 5, MASP1, CRARF, CRARF1, PRSS5, Complement-activating component of Ra-reactive factor, Ra-reactive factor serine protease p100

SwissProt ID

P48740 (Human), P98064 (Mouse), Q8CHN8 (Rat)

Gene ID

5648 (MASP1), 17174 (Masp1), 64023

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Rat

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP)

Background of MASP-1 antibody

Three pathways of complement activation have been reported: the antibody-dependent classical pathway, the antibody-independent alternative pathway and the lectin pathway. Activation of each pathway involves formation of serine protease complexes, which results in activation of the central complement component, C3. In the lectin pathway, mannose- binding-lectin (MBL)-associated serine proteases (MASP) form complexes with oligopolymeric lectin molecules, which are involved in pattern recognition. Upon binding of the recognition molecules to carbohydrates on the surface of microorganisms, MASPs are converted to their active forms and initiate complement activation. Six members of the family of MASP-like serine proteases have been reported: MASP-1, MASP-2, MASP-3, Map19, C1r and C1s. These products show identical domain organization, even though the overall amino acid sequence identity is only approximately 40%. Each MASP-type forms homodimers and is individually associated with MBL and the ficolins in a Ca2+-dependent matter. The four MBL-associated proteins are generated from only two genes, the MASP-1/3 gene encodes MASP-1 and MASP-3, whereas the MASP-2/Map19 gene gives rise to MASP-2 and the non-enzymatic MASP-2 MAp19. MASP-1 associates preferentially with low oligomer MBL (termed MBL-I), whereas MASP-2 and MASP-3 associate mainly with larger MBL oligomers (MBL II and MBL III). MASP-3 is generated by alternative splicing of the MASP-1/3 gene. The MASP-3 transcription product is composed of an A chain, which is common to both MASP-1 and MASP-3, and a B chain, which is unique to MASP- 3. The biological function of MASP-3 remains unclear. However, MASP-3 was found to downregulate the C4 and C2 cleaving activity of MASP-2. MASP-3 inhibits MASP-2 by a combination of competitive inhibition of MASP-2 association with MBL and inhibition of activation of the MBL-associated MASP-2.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MASP-1 antibody

  Rabbit polyclonal MASP1 (heavy chain, Cleaved-Arg448) antibody  
Western blot analysis of extracts from A549 cells, treated with etoposide (25uM, 24hours), using MASP1 (heavy chain, Cleaved-Arg448) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MASP-1 antibody

  Rabbit Polyclonal Anti-MASP1 Antibody  
WB Suggested Anti-MASP1 Antibody; Titration: 1.0 ug/ml; Positive Control: HT1080 Whole Cell Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MASP-1 antibody

MASP-1 Rat IgG2a 38:12-3b Purified Hu E, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

MASP-1 antibody

Western Blot analysis of MASP1 expression in transfected 293T cell line (H00005648-T01) by MASP1 MaxPab polyclonal antibody.

Lane 1: MASP1 transfected lysate(41.8 KDa).
Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MASP-1 antibody

Western Blot analysis of MASP1 expression in transfected 293T cell line (H00005648-T02) by MASP1 MaxPab polyclonal antibody.

Lane 1: MASP1 transfected lysate(43.60 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MASP-1 (cleaved) antibody

Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 24h, using MASP1 (heavy chain,Cleaved-Arg448) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €230.00
  Assay Biotech

MASP-1 (cleaved) antibody

Western blot analysis of extracts from A549 cells, treated with etoposide 25uM 24h, using MASP1 (heavy chain,Cleaved-Arg448) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Assay Biotech

MASP-1 antibody

Western blot analysis of MASP1 HC expression in A549 colchicine-treated (A); mouse lung (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

MASP-1 antibody

Western blot analysis of MASP1 HC expression in A549 colchicine-treated (A); mouse lung (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

MASP-1 antibody

Western blot analysis of MASP1 HC expression in A549 colchicine-treated (A); mouse lung (B); rat liver (C) whole cell lysates. Rabbit Aff - Purified Hu, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

MASP-1/3 antibody

MASP-1/3 Mouse IgG1 1E2 Purified Hu E, IP, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

MASP-1/3 antibody

MASP-1/3 Mouse IgG1 2B11 Purified Hu E, IP, WB
0.1 mg / €500.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MASP1 - human gene knockout kit via CRISPR

MASP1 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MASP1 - human gene knockout kit via CRISPR

MASP1 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MASP1 - human gene knockout kit via CRISPR

MASP1 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MASP1 - human gene knockout kit via CRISPR

MASP1 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Masp1 - mouse gene knockout kit via CRISPR

Masp1 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Masp1 - mouse gene knockout kit via CRISPR

Masp1 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Masp1 - mouse gene knockout kit via CRISPR

Masp1 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Masp1 - mouse gene knockout kit via CRISPR

Masp1 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

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