MAVS antibody

Principal name

MAVS antibody

Alternative names for MAVS antibody

IPS1, VISA, Mitochondrial antiviral-signaling protein, Cardif, Virus-induced-signaling adapter, CARD adapter inducing interferon-beta, Putative NF-kappa-B-activating protein 031N, nterferon-beta promoter stimulator protein 1, Mitochondrial antiviral-signaling protein

SwissProt ID

Q66HG9 (Rat), Q7Z434 (Human), Q8VCF0 (Mouse)

Gene ID

57506 (MAVS), 311430 (Mavs), 228607

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of MAVS antibody

Double-stranded R viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic R helicases MDA5 and RIGI (ROBO3). These interactions initiate sigling pathways that differ in their initial steps but converge in the activation of the protein kises IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded R viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic R helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate sigling pathways that differ in their initial steps but converge in the activation of the protein kises IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Seth R.B., et al. (2005) Cell. 122:669-682Xu L.-G., et al. (2005) Mol. Cell. 19:727-740

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAVS antibody

  MAVS mouse monoclonal antibody, clone OTI9C4 (formerly 9C4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MAVS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808253)(1:150) Mouse IgG1 OTI9C4 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MAVS (N-term) antibody

  Rabbit Polyclonal VISA Antibody  
Western blot analysis of VISA in A20 cell lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS (Center) antibody

  Rabbit Polyclonal VISA Antibody  
Western blot analysis of VISA in rat brain tissue lysate with VISA antibody at (A) 0.5, (B) 1 and (C) 2 ug/ml. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Rabbit anti-MAVS Polyclonal Antibody  
Western blot analysis of extracts of various cell lines, using MAVS antibody. Rabbit IgG Purified Hu
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Mouse Monoclonal MAVS Antibody (58N3E1)  
Western Blot: MAVS Antibody (58N3E1) [TA336937] - Analysis of A) partial recombinant protein and B) human HeLa lysate using IPS-1 antibody at 0.1 ug/ml and 2 ug/ml, respectively. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solutio Mouse IgG2b 58N3E1 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Mouse Monoclonal MAVS Antibody (58N2B2)  
Western Blot: MAVS Antibody (58N2B2) [TA336938] - Analysis of A) partial recombinant protein and B) human Jurkat lysate using MAVS antibody at 0.1 ug/ml and 2 ug/ml, respectively. goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate soluti Mouse IgG2b 58N2B2 Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Mouse Monoclonal MAVS Antibody (58N3B6)  
Western Blot: MAVS Antibody (58N3B6) [TA336939] - Analysis of A) partial recombinant protein and B) human HeLa lysate using MAVS antibody at 0.1 ug/ml and 2 ug/ml, respectively. Goat anti-mouse Ig HRP secondary antibody and PicoTect ECL substrate solution Mouse IgG2b 58N3B6 Purified Hu C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Rabbit Polyclonal Anti-MAVS Antibody  
WB Suggested Anti-MAVSAntibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 12500; Positive Control: Transfected 293T Rabbit IgG Purified Bov, Hu, Ms ICC/IF, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  Rabbit Polyclonal Anti-MAVS Antibody  
WB Suggested Anti-MAVSAntibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 62500; Positive Control: Transfected 293T Rabbit IgG Purified Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MAVS antibody

  MAVS mouse monoclonal antibody, clone OTI8A11 (formerly 8A11)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MAVS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120 oC for 3 min, TA808251)(1:150) Mouse IgG1 OTI8A11 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MAVS antibody

  MAVS mouse monoclonal antibody, clone OTI9C7 (formerly 9C7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MAVS (RC208175, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MAVS.(1:2000) Mouse IgG3 OTI9C7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MAVS antibody

Brain, cortex: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MAVS antibody

Figure 1. Staining MAVS (VISA) in Thymus tissue by Immunohistochemistry using Formalin-Fixed Paraffin-Embedded (FFPE) tissue. Rabbit Purified Hu, Ms, Rt P, WB
50 µg / €470.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MAVS - human gene knockout kit via CRISPR

MAVS - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MAVS - human gene knockout kit via CRISPR

MAVS - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MAVS - human gene knockout kit via CRISPR

MAVS - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MAVS - human gene knockout kit via CRISPR

MAVS - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MAVS

  Recombinant protein of human virus-induced signaling adapter (VISA), nuclear gene encoding mitochondrial protein  
MAVS Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

MAVS (1-513, His-tag)

MAVS Human Purified > 85 % by SDS - PAGE E. coli
50 µg / €730.00
  Acris Antibodies GmbH

MAVS (1-513, His-tag)

MAVS Human Purified > 85 % by SDS - PAGE E. coli
10 µg / €300.00
  Acris Antibodies GmbH

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