MAVS antibody

Principal name

MAVS antibody

Alternative names for MAVS antibody

IPS1, VISA, Mitochondrial antiviral-signaling protein, Cardif, Virus-induced-signaling adapter, CARD adapter inducing interferon-beta, Putative NF-kappa-B-activating protein 031N, nterferon-beta promoter stimulator protein 1, Mitochondrial antiviral-signaling protein

SwissProt ID

Q66HG9 (Rat), Q7Z434 (Human), Q8VCF0 (Mouse)

Gene ID

57506 (MAVS), 311430 (Mavs), 228607

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Enzyme Immunoassay (E), Frozen Sections (C)

Background of MAVS antibody

Double-stranded R viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 or by the cytoplasmic R helicases MDA5 and RIGI (ROBO3). These interactions initiate sigling pathways that differ in their initial steps but converge in the activation of the protein kises IKKA (CHUK) and IKKB (IKBKB), which activate NFKB, or TBK1 and IKKE (IKBKE), which activate IRF3. Activated IRF3 and NFKB induce transcription of IFNB (IFNB1). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1). For RIGI, the intermediary protein is mitochondria-bound VISA. Double-stranded R viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic R helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate sigling pathways that differ in their initial steps but converge in the activation of the protein kises IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

General readings

Seth R.B., et al. (2005) Cell. 122:669-682Xu L.-G., et al. (2005) Mol. Cell. 19:727-740

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MAVS antibody

  MAVS mouse monoclonal antibody, clone OTI9C4 (formerly 9C4)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MAVS mouse monoclonal antibody. (Heat-induced epitope retrieval by 1mM EDTA in 10mM Tris buffer (pH8.5) at 120°C for 3 min, TA808253)(1:150) Mouse IgG1 OTI9C4 Purified Hu P, WB
0.1 ml / €350.00
  OriGene Technologies, Inc.

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