MBD2 antibody

Principal name

MBD2 antibody

Alternative names for MBD2 antibody

Methyl-CpG-binding domain protein 2, Demethylase, DMTase

SwissProt ID

Q9UBB5 (Human), Q9Z2E1 (Mouse)

Gene ID

8932 (MBD2), 17191 (Mbd2)

Available reactivities

Bov (Bovine), Can (Canine), Chk (Chicken), Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), African clawed frog, Bt (Bat), Eq (Equine), Hst (Hamster), Mky (Monkey), Op (Opossum), Por (Porcine), Prim (Primate), Rb (Rabbit), Bear, GP (Guinea Pig)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MBD2 antibody

MBD2 belongs to a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated D. MBD2 can also repress transcription from methylated gene promoters. MBD2 may function as a mediator of the biological consequences of the methylation sigl.It is also reported that the MBD2 functions as a demethylase to activate transcription, as D methylation causes gene silencing.D methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated D. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation sigl. It is also reported that the this protein functions as a demethylase to activate transcription, as D methylation causes gene silencing. D methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated D. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation sigl. It is also reported that the this protein functions as a demethylase to activate transcription, as D methylation causes gene silencing.

General readings

Le (2006) Mol. Cell. Biol. 26 (3), 843-851

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MBD2 (15-29) antibody

Human Skin (formalin-fixed, paraffin-embedded) stained with MBD2 antibody AP22575PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Aff - Purified Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Por, Rb, Rt E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MBD2 (isoform 1) antibody

  Goat Polyclonal Antibody against MBD2  
TA303172 (0.3µg/ml) staining of Jurkat cell lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBD2 antibody

  Rabbit polyclonal anti-MBD2a antibody  
Western blot analysis of MBD2a using Jurkat cell lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBD2 antibody

  Rabbit polyclonal MBD2 Antibody (Center)  
MBD2 Antibody (Center) (Cat. #TA324684) western blot analysis in HL-60 cell line lysates (35ug/lane).This demonstrates the MBD2  antibody detected the MBD2  protein (arrow). Rabbit IgG Purified Hu, Ms ICC/IF, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MBD2 antibody

  Rabbit Polyclonal Anti-MBD2 Antibody  
Lanes: ; Lane 1: 15ug WT mouse ES lysate; Lane 2: 15ug MBD2 KO mouse ES lysate; Primary Antibody Dilution: ; 1:1000; Secondary Antibody: ; Goat anti-rabbit-HRP; Secondary Antibody Dilution: ; 1:2500; Gene Name: ; MBD2 a; Submitted by: ; Austin J. Cooney, Rabbit IgG Purified Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MBD2 antibody

  Rabbit Polyclonal Anti-MBD2 Antibody  
Lanes: Lane 1: 15ug WT mouse ES lysate; Lane 2: 15ug MBD2 KO mouse ES lysate; Primary Antibody Dilution: 1: 1000; Secondary Antibody: Goat anti-rabbit-HRP; Secondary Antibody Dilution: 1: 2500; Gene Name: MBD2 Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBD2 antibody

  Rabbit Polyclonal MBD2 Antibody  
WB was performed on nuclear extracts from mouse fibroblastst (NIH3T3) and embryonic stem cells (E14Tg2a) with the antibody against mouse MBD2, diluted 1:500 in BSA/PBS-Tween. The molecular weight marker (M, in kDa) is shown on the left; the location of the protein of interest is indicated on the right. Rabbit IgG Purified Ms E
0.1 ml / €325.00
  OriGene Technologies, Inc.

MBD2 (N-term) antibody

Western Blot analysis of anti-MBD2 N-term Antibody (Cat.#AP11082PU-N) to detect MBD2 in A375 cell lysate (lane 1) and mouse brain tissue lysate (lane 2) lysate. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MBD2 antibody

Kidney stained in IHC-P with MBD2 antibody Rabbit Purified Hu C, E, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MBD2 - human gene knockout kit via CRISPR

MBD2 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MBD2 - human gene knockout kit via CRISPR

MBD2 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MBD2 - human gene knockout kit via CRISPR

MBD2 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MBD2 - human gene knockout kit via CRISPR

MBD2 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbd2 - mouse gene knockout kit via CRISPR

Mbd2 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mbd2 - mouse gene knockout kit via CRISPR

Mbd2 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbd2 - mouse gene knockout kit via CRISPR

Mbd2 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbd2 - mouse gene knockout kit via CRISPR

Mbd2 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MBD2 (mGFP-tagged)-Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MBD2 (mGFP-tagged)-Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, MBD2 (Myc-DDK-tagged)-Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MBD2 (Myc-DDK-tagged)-Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Lenti ORF particles, MBD2 (Myc-DDK tagged) - Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MBD2 (Myc-DDK tagged) - Human methyl-CpG binding domain protein 2 (MBD2), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

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