MBD4 antibody

Principal name

MBD4 antibody

Alternative names for MBD4 antibody

Methyl-CpG-binding domain protein 4, MED1, Mismatch-specific DNA N-glycosylase

SwissProt ID

O95243 (Human), Q9Z2D7 (Mouse)

Gene ID

8930 (MBD4), 17193 (Mbd4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), GP (Guinea Pig)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MBD4 antibody

MBD4 is involved with D methylation. D methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD3 comprise a family of nuclear proteins related by??he presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated D. MBD4 may function to mediate the biological consequences of the methylation sigl. In addition, MBD4 has protein sequence similarity to bacterial D repair enzymes and thus may have some function in D repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective D mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bo fide MIS target gene.D methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated D. MBD4 may function to mediate the biological consequences of the methylation sigl. In addition, MBD4 has protein sequence similarity to bacterial D repair enzymes and thus may have some function in D repair. Further, MBD4 gene mutations are detected in tumors with primary microsatellite-instability (MSI), a form of genomic instability associated with defective D mismatch repair, and MBD4 gene meets 4 of 5 criteria of a bo fide MIS target gene. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additiol publications.

10 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MBD4 antibody

  Rabbit Polyclonal MBD4 Antibody  
Immunohistochemistry: MBD4 Antibody - IHC analysis of MBD4 in human breast cancer cells using DAB with hematoxylin counterstain. Rabbit Purified Hu C, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

MBD4 antibody

  Rabbit polyclonal anti-MBD4 antibody  
Western blot analysis of MBD4 using Jurkat cell lysate. Rabbit Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBD4 antibody

  Rabbit Polyclonal Anti-MBD4 Antibody  
WB Suggested Anti-MBD4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: Hela cell lysate MBD4 is strongly supported by BioGPS gene expression data to be expressed in Human HeLa cells Rabbit IgG Purified GP, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MBD4 antibody

  Rabbit Polyclonal MBD4 Antibody  
WB analysis with the antibody against the TY1-tag (lane 1) and with the antibody against MBD4(lane 2), diluted 1:2,000 in TBST containing 3% milk powder. Figure 2B: WB was performed on nuclear extracts from the U937 human leukemic monocyte lymphoma cell line (40 ug) with the antibody against MBD4, diluted 1:2,000 in TBST containing 3% milk powder. A molecular weight marker (in kDa) is shown on the left. The location of the protein of interest is indicated on the right. Rabbit IgG Purified Hu E
0.1 ml / €325.00
  OriGene Technologies, Inc.

CRISPR

Catalog No. Species Donor Vector  

Mbd4 - mouse gene knockout kit via CRISPR

Mbd4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mbd4 - mouse gene knockout kit via CRISPR

Mbd4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbd4 - mouse gene knockout kit via CRISPR

Mbd4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mbd4 - mouse gene knockout kit via CRISPR

Mbd4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MBD4 overexpression lysate

MBD4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

Lysates (Knockout)

Catalog No.    

MBD4-knockout Cell lysate

MBD4-knockout Cell lysate  
0.1 mg / €495.00
  OriGene Technologies, Inc.

10 Item(s)

per page
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