MBNL1 antibody

Principal name

MBNL1 antibody

Alternative names for MBNL1 antibody

Muscleblind-like protein 1, EXP

SwissProt ID

Q5ZKW9 (Chick), Q9JKP5 (Mouse), Q9NR56 (Human)

Gene ID

4154 (MBNL1), 4441549 (ackA)

Available reactivities

Hu (Human), Can (Canine), Chk (Chicken), Ms (Mouse), Ze (Zebrafish), Rt (Rat), Bov (Bovine), Eq (Equine), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of MBNL1 antibody

pre-mRs splicing /removal of non-coding regions is a critical process which contributes to a diverse proteome as well as gene expression regulation, and there are several splicing factors that are exclusively involved in a subset of splicing decisions - human muscleblind-like family of R-binding proteins: MBNL1/2/3 also known as MBNL/EXP, MBLL/MPL1, and MBXL/CHCR, respectively. Muscleblind-like 1 (MBNL1) is a known mediator of pre-mR altertive splicing regulation and it acts either as activator or repressor of splicing on specific pre-mR targets. Several pathologies are linked to expansion of polynucleotide sequences (mostly trinucleotide repeats) and CUG/CCUG expansion Rs accumulates in Myotonic Dystrophy patient cells wherein it contributes to the disease by dysregulating altertive splicing factors such as CUGBP, Elav-like Family Member 1 (CELF1) and MBNL1. The expanded CUG repeats sequester MBNL proteins into nuclear foci, leading to loss of active protein and the sequestration of MBNL1 leads to missplicing of developmentally regulated events that are responsible for symptoms in DM types 1 and 2, such as the missplicing of the chloride channel (CLCN1) leading to myotonia. CELF1 and MBNL1 regulate a number of common splicing events, but in opposite directions and loss of MBNL1 activity is more critical than upregulation of CELF1 activity for abnormal splicing.

General readings

Warf MB, Berglund JA.
MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T.
RNA. 2007 Dec;13(12):2238-51.
PMID: 17942744

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MBNL1 antibody

Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse IgG2a 3E7 Hu E, ICC/IF, P, WB
50 µg / €530.00
  Acris Antibodies GmbH

MBNL1 antibody

Immunoperoxidase of monoclonal antibody to MBNL1 on formalin-fixed paraffin-embedded human esophagus. [antibody concentration 0.75 ug/ml] Mouse IgG2a 3E7 Purified Hu E, ICC/IF, P, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MBNL1 (C-term) antibody

TA305699 (1ug/ml) staining of HeLa lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Can, Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBNL1 antibody

Western Blot: Muscleblind-like 1 Antibody (HL-1822 3A4-1E9) [TA336512] - Detection of Muscleblind in HeLa whole cell extract (33ug) using NB 110-37256. Mouse IgG1 HL-1822 3A4-1E9 Purified Hu, Ms, Rt C, ICC/IF, P, WB
0.5 ml / €325.00
  OriGene Technologies, Inc.

MBNL1 antibody

WB Suggested Anti-MBNL1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 1562500; Positive Control: Jurkat cell lysate; MBNL1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Can, Eq, Hu, Ms, Por, Rb, Rt, Ze P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MBNL1 antibody

WB Suggested Anti-MBNL1 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1: 62500; Positive Control: Jurkat cell lysateMBNL1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells Rabbit IgG Purified Hu, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MBNL1 antibody

MBNL1 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MBNL1 antibody

MBNL1 monoclonal antibody (M01), clone 1D11 Western Blot analysis of MBNL1 expression in Hela NE ( Cat # L013V3 ). Mouse IgG1 1D11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MBNL1 antibody

MBNL1 Mouse IgG1 1D11 Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

MBNL1 antibody

MBNL1 Mouse IgG1 1D11 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MBNL1 antibody

MBNL1 polyclonal antibody ( Cat # PAB11459 ) ( 1 µg/ml ) staining of HeLa lysate ( 35 µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MBNL1 antibody

Human Heart; . Rabbit Anti-MBNL1 Antibody. . Catalog Number:. ARP41227 . Paraffin Embedded Tissue: Human cardiac cell . Cellular Data: Epithelial cells of renal tubule. Antibody Concentration: 4.0-8.0 ug/ml. Magnification: 400X Rabbit IgG Aff - Purified Can, Chk, Hu, Ms, Ze P, WB
50 µg / €350.00
  AVIVA Systems Biology

MBNL1 antibody

Human Jurkat; WB Suggested Anti-MBNL1 Antibody Titration: 2.5ug/ml. ELISA Titer: 1:62500. Positive Control: Jurkat cell lysate. MBNL1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells.; MBNL1 antibody - C-terminal region (ARP41228_T100) in Human Jurkat cells using Western Blot Rabbit Aff - Purified Can, Hu WB
0.1 mg / €310.00
  AVIVA Systems Biology

MBNL1 antibody

MBNL1 Mouse IgG1 HL-1822 3A4-1E9 Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €160.00
  Novus Biologicals Inc.

MBNL1 antibody

Western Blot: MBNL1 Antibody [NBP1-06990]-1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

MBNL1 antibody

MBNL1 Rabbit Aff - Purified Can, Chk, Hu, Ms, Ze P, WB
50 µg / €440.00
  Novus Biologicals Inc.

MBNL1 antibody

MBNL1 Rabbit Purified Can, Hu WB
0.1 mg / €360.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MBNL1 (transcript variant 6)

MBNL1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MBNL1 (transcript variant 1)

MBNL1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MBNL1 (transcript variant 5)

MBNL1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

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