MBNL2 antibody

Principal name

MBNL2 antibody

Alternative names for MBNL2 antibody

MBLL, MBLL39, MLP1, Muscleblind-like protein 1, Muscleblind-like protein 2, Muscleblind-like protein-like, Muscleblind-like protein-like 39

SwissProt ID

F2Z3T4, Q5VZF2 (Human), Q8C181 (Mouse)

Gene ID

10150 (MBNL2), 680445 (Mbnl2)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB)

Background of MBNL2 antibody

Mbnl2 mediates pre-mR altertive splicing regulation. It acts either as activator or repressor of splicing on specific pre-mR targets. It inhibits cardiac troponin-T (TNNT2) pre-mR exon inclusion but induces insulin receptor (IR) pre-mR exon inclusion in muscle. It antagonizes the altertive splicing activity pattern of CELF proteins. R-binding protein that binds to 5'ACACCC-3' core sequence, termed zipcode, within the 3'UTR of ITGA3. It binds to CUG triplet repeat expansion in myotonic dystrophy muscle cells by sequestering the target Rs. It seems to regulate expression and localization of ITGA3 by transporting it from the nucleus to cytoplasm at adhesion plaques. It may play a role in myotonic dystrophy pathophysiology (DM).

General readings

Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010)
He, F., et al. Protein Sci. 18(1):80-91(2009)
Holt, I., et al. Am. J. Pathol. 174(1):216-227(2009)
Paul, S., et al. EMBO J. 25(18):4271-4283(2006)
Adereth, Y., et al. Nat. Cell Biol. 7(12):1240-1247(2005)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MBNL2 antibody

WB Suggested Anti-MBNL2 Antibody Titration: 0.2-1 ug/ml; Positive Control: Human brain Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MBNL2 antibody

Host: Rabbit; Target Name: Mbnl2; Sample Tissue: Rat Brain lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MBNL2 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue reacted with MBNL2 Antibody (C-term) Cat.-No AP52623PU-N, which was peroxidase conjugated to the secondary antibody and followed by AB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MBNL2 antibody

MBNL2 Mouse IgG1 3C3 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

MBNL2 antibody

MBNL2 Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MBNL2 (transcript variant 3)

MBNL2 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MBNL2

MBNL2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MBNL2

MBNL2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MBNL2

MBNL2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MBNL2

MBNL2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MBNL2 overexpression lysate

MBNL2 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

11 Item(s)

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