MC1-R antibody

Principal name

MC1-R antibody

Alternative names for MC1-R antibody

Melanotropin receptor, Melanocortin receptor 1, MC1R, MSHR, MSH-R, Melanocyte-stimulating hormone receptor

SwissProt ID

P47798 (Bovin), Q01726 (Human), Q01727 (Mouse), Q9TU05 (Pig)

Gene ID

4157 (MC1R)

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Gorilla, Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of MC1-R antibody

Melanocortin Receptor 1 (MC1R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of a-, Ã?- and ?-melanocyte stimulating hormone (a, Ã?, ?-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translatiol processing of a common precursor peptide, proopiomelanocortin (POMC). One of the most salient features of the melanocortin sigling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti sigling protein, ASP) and agouti-related protein (AGRP). All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities. MC1R was the first member of the melanocortin receptor family to be cloned. The receptor transduces sigls via Gs resulting in the activation of adenylate cyclase and production of cAMP. MC1R binds its ligands with the following potency: a-MSH = ACTH > Ã?-MSH > ?-MSH. MC1R also binds the endogenous antagonist agouti with high affinity. MC1R can be described as the â??classicalâ? melanocyte a-MSH receptor. The receptor is expressed in the skin where it has a key role in determining skin and hair pigmentation. In fur-bearing mammals, the local ratio between a-MSH and agouti will determine coat pigmentation as a-MSH stimulates and agouti inhibits melanin production. In humans, especially in Caucasians, the MC1R gene is highly polymorphic and several allelic variants have been correlated with red-hair, poor tanning ability and increased risk of melanoma. In addition, MC1R expression in melanoma has been shown to be upregulated up to 20-fold when compared to normal melanocytes. The melanocortins and particularly a-MSH have significant anti-inflammatory properties. Since a-MSH binds to MC1R with the highest potency, it was proposed that the latter mediated the anti-inflammatory effects of a-MSH. Indeed, MC1R expression has been demonstrated in several cells of the immune system including macrophages and neutrophils.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC1-R antibody

Western blot analysis of human normal skin fibroblast cell line Malme-3 (lanes 1 and 4) and human malignant melanoma cell lines Malme-3M (lanes 2 and 5) and A875 (lanes 3 and 6): 1, 2, 3. Anti-Melanocortin Receptor 1 antibody, (1:500). 4, 5, 6. Anti-Melanocortin Receptor 1 antibody, preincubated with the control peptide antigen Rabbit Purified Hu, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC1-R antibody

Sample (30 ug of whole cell lysate). A: Molt-4 . 10% SDS PAGE. TA308794 diluted at 1:1000. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC1-R antibody

Western blot analysis of extracts from COLO205 cells, using MSHR antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC1-R antibody

Predicted band size: 35 kDa . Positive control: Mouse intestinum tenue tissue lysate. Recommended dilution: 1/500-2000. (Gel: 10%SDS-PAGE Lysate: 40 ug Primary antibody: 1/1450 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC1-R antibody

Predicted cell location: Cytoplasm. Positive control: Human gastric and colon cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using MC1R antibody at dilution 1/100, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC1-R antibody

WB Suggested Anti-MC1R Antibody; Titration: 1.0 ug/ml; Positive Control: HepG2 Whole Cell Rabbit IgG Purified Hu, Ms, Por, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MC1-R antibody

Western blot analysis of MC1-R Antibody Cat.-No AP01272PU-N in extracts from COLO205 cells. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MC1-R antibody

MC1-R Rabbit Purified Hu, Mky C, E, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MC1-R antibody

MC1-R Mouse Serum Hu E
50 µl / €290.00
  Abnova Taiwan Corp.

MC1-R antibody

Immunofluorescence analysis of LOVO cells, using MSHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

MC1-R antibody

Immunofluorescence analysis of LOVO cells, using MSHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

MC1-R antibody

Western Blot: MC1-R Antibody [NBP1-00912] - Western blot (WB) analysis of MC1-R (V312) antibody in extracts from COLO205 cells Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

MC1-R antibody

Immunohistochemistry-Paraffin: MC1 Receptor Antibody (EPR6530) [NBP1-96040] human melanoma tissue using anti-MC1R. Rabbit EPR6530 Purified Hu P, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MC1-R

MC1-R Human
2 µg / €300.00
  Abnova Taiwan Corp.

MC1-R

MC1-R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MC1-R

MC1-R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

16 Item(s)

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