MC2-R antibody

Principal name

MC2-R antibody

Alternative names for MC2-R antibody

MC2R, ACTHR, ACTH receptor, ACTH-R, Adrenocorticotropin receptor, Adrenocorticotropic hormone receptor

SwissProt ID

P34974 (Bovin), Q01718 (Human), Q64326 (Mouse), Q8HYN8 (Pig)

Gene ID

4158 (MC2R)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P)

Background of MC2-R antibody

Melanocortin Receptor 2 (MC2R) belongs to a five-member receptor family known as the melanocortin receptors. The melanocortin receptors are members of the 7 transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The receptors ligands, the melanocortins, are a group of structurally derived peptides consisting of a-, Ã?- and ? melanocyte stimulating hormone (a, Ã?, ?-MSH) and the adrenocorticotropic hormone (ACTH) all of which are derived from the post-translatiol processing of a common precursor peptide, proopiomelanocortin (POMC). One of the most salient features of the melanocortin sigling system is the presence of two endogenous antagonists, that is proteins that bind specifically to the receptor but instead of activating it have an inhibitory effect. The antagonist proteins are termed agouti (or agouti sigling protein, ASP) and agouti-related protein (AGRP). All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with different affinities. MC2R can be also described as the ACTH receptor as it is exclusively activated by the ACTH hormone. In fact, MC2R mediates all the physiological effects of ACTH in the adrel cortex, that is the regulation and production of steroids, their circadian variation and their stress-related fluctuations. In addition, mutations that result in MC2R functiol impairment are associated with familial glucocorticoid deficiency. The receptor transduces sigls via Gs resulting in the activation of adenylate cyclase and production of cAMP.

General readings

Kilianova Z, Basora N, Kilian P, Payet MD, Gallo-Payet N.
Human melanocortin receptor 2 expression and functionality: effects of protein kinase A and protein kinase C on desensitization and internalization.
Endocrinology. 2006 May;147(5):2325-37. Epub 2006 Feb 23.
PMID: 16497811

14 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC2-R (N-term) antibody

TA303323 (1µg/ml) staining of Human Skin lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC2-R antibody

Western blot analysis of extracts from HeLa cells, using ACTHR antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC2-R antibody

Predicted band size: 34 kDa . Positive control: Human fetal kidney tissue lysate. Recommended dilution: 1/1000-5000. (Gel: 10%SDS-PAGE Lysate: 40 ug per lane Primary antibody: 1/1400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC2-R antibody

Western blot analysis of extracts of 293 cell lysate, using MC2R antibody. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC2-R antibody

Western blot analysis of rat adrenal lysate: 1. Anti-Melanocortin Receptor 2 (extracellular) antibody (1:400). 2. Anti-Melanocortin Receptor 2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC2-R antibody

Western blot (WB) analysis of Adenosine MC2-R antibody (Cat.-No.: AP01306PU-N) in extracts from HeLa cells. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MC2-R antibody

MC2R polyclonal antibody ( Cat # PAB7439 ) ( 1 µg/ml ) staining of human skin lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MC2-R antibody

Immunofluorescence analysis of MCF7 cells, using ACTHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

MC2-R antibody

Immunofluorescence analysis of MCF7 cells, using ACTHR Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

MC2-R antibody

NB100-93419 (1ug/ml) staining of Human Skin lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence Goat IgG Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MC2-R

MC2-R Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

MC2-R

MC2-R Human
2 µg / €450.00
  Abnova Taiwan Corp.

MC2-R

MC2-R Human Purified
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MC2R overexpression lysate

MC2R overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

14 Item(s)

per page
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