MC3-R antibody

Principal name

MC3-R antibody

Alternative names for MC3-R antibody

MC3R, Melanocortin receptor 3

SwissProt ID

P32244 (Rat), P33033 (Mouse), P41968 (Human)

Gene ID

4159 (MC3R), 29310 (Mc3r), 17201

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Por (Porcine)

Available hosts

Mouse, Goat, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP)

Background of MC3-R antibody

Melanocortin Receptor 3 (MC3R) is one of five members of the melanocortin receptor family, which belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The ligands of these receptors, the melanocortins, are a group of structurally-related peptides comprising the a-, Ã?-, and ?-melanocyte-stimulating hormone (a-, Ã?-, ?-MSH) and the adrenocorticotropic hormone (ACTH), all of which are derived from post-translatiol processing of a common precursor peptide, proopiomelanocortin (POMC). One of the salient features of the melanocortin sigling system is the presence of two endogenous antagonists, proteins that bind specifically to the receptor and have an inhibitory effect. These antagonist proteins are termed agouti (or agouti sigling protein, ASP) and agouti-related protein (AGRP). All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti and AGRP) with differing affinities. MC3R is the only one of the melanocortin receptors that shows no difference in binding specificity for any of the melanocortins, binding all of them with equal efficiency. AGRP is the high affinity endogenous antagonist of MC3R. The physiological function of MC3R is still poorly understood. The distribution of MC3R in hypothalamic nuclei of the central nervous system (CNS) suggests a role in the regulation of energy homeostasis. Indeed, studies with MC3R knockout (MC3R KO) mice showed that these mice have increased body fat due to increased feed efficiency. In humans, several polymorphisms of the MC3R gene are associated with high insulin levels and obesity in children. In addition, expression of MC3R in macrophages is thought to mediate the well known anti-inflammatory effects of a-MSH.

General readings

Muhlhausler BS, Adam CL, Marrocco E, Findlay PA, Roberts CT, McFarlane JR, Kauter KG, McMillen IC. Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. J Physiol. 2005 Jan 20

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC3-R (N-term) antibody

  Goat Polyclonal Antibody against MC3R  
TA303015 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Chimp, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC3-R antibody

  Rabbit Polyclonal Anti-Melanocortin Receptor 3 (extracellular)  
Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1, 2. Anti-Melanocortin Receptor 3 (extracellular) antibody, (1:200). 3, 4. Anti-Melanocortin Receptor 3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC3-R antibody

  Rabbit Polyclonal Anti-MC3R Antibody (C-Terminus)  
Anti-MC3 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Eq, Hst, Hu, Ms, Por, Rt
50 µg / €400.00
  OriGene Technologies, Inc.

MC3-R antibody

Western blot analysis of MC3R Antibody (Center) (AP18111PU-N) in K562 cell line lysates (35ug/lane). MC3R (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MC3R - human gene knockout kit via CRISPR

MC3R - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MC3R - human gene knockout kit via CRISPR

MC3R - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MC3R - human gene knockout kit via CRISPR

MC3R - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MC3R - human gene knockout kit via CRISPR

MC3R - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc3r - mouse gene knockout kit via CRISPR

Mc3r - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mc3r - mouse gene knockout kit via CRISPR

Mc3r - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc3r - mouse gene knockout kit via CRISPR

Mc3r - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc3r - mouse gene knockout kit via CRISPR

Mc3r - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MC3R (mGFP-tagged) - Human melanocortin 3 receptor (MC3R), 200 uL, >10^7 TU/mL

Lenti ORF particles, MC3R (mGFP-tagged) - Human melanocortin 3 receptor (MC3R), 200 uL, >10^7 TU/mL  
200 µl / €960.00
  OriGene Technologies, Inc.

Lenti ORF particles, MC3R (Myc-DDK tagged) - Human melanocortin 3 receptor (MC3R) , 200 uL, >10^7 TU/mL

Lenti ORF particles, MC3R (Myc-DDK tagged) - Human melanocortin 3 receptor (MC3R) , 200 uL, >10^7 TU/mL  
200 µl / €860.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mc3r (Myc-DDK-tagged) - Mouse melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mc3r (Myc-DDK-tagged) - Mouse melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mc3r (GFP-tagged ORF) - Rat melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mc3r (GFP-tagged ORF) - Rat melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mc3r (Myc-DDK-tagged ORF) - Rat melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mc3r (Myc-DDK-tagged ORF) - Rat melanocortin 3 receptor (Mc3r), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

17 Item(s)

per page
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