MC3-R antibody

Principal name

MC3-R antibody

Alternative names for MC3-R antibody

MC3R, Melanocortin receptor 3

SwissProt ID

P32244 (Rat), P33033 (Mouse), P41968 (Human)

Gene ID

4159 (MC3R), 29310

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chimp (Chimpanzee), Bov (Bovine), Can (Canine), Eq (Equine), Hst (Hamster), Por (Porcine)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Paraffin Sections (P)

Background of MC3-R antibody

The melanocortin (MC) peptides are regulatory peptides derived by post-translational processing of the larger pro-opiomelanocortin (POMC) precursor, and include the adrenocorticotropic hormone (ACTH) and the melanocyte stimulating hormones (alpha, beta and gamma MSH). The melanocortins are produced primarily in the anterior and intermediate lobes of the pituitary, in the arcuate nucleus of the hypothalamus, and to a lower level in various other peripheral tissues. In addition to their well established melanotropic and adrenocorticotropic actions, these peptides have been reported to exert a broad variety of physiological actions including those related to central neural function such as behavior, memory, cognition, and regulation of feeding. Melanocortin peptides mediate their action through G-protein coupled receptors. Five melanocortin receptors (MCRs) are known to exist. These include the melanocortin receptors MC1R to MC5R. The melanocortin receptors are differentially distributed and expressed in the brain and various tissues in the periphery. MC3R is a 360 amino acid transmembrane protein belonging to the G-protein coupled receptor family. The melanocortin 3 receptor (MC3R) is expressed primarily in the adult central nervous system at high levels in a restricted number of neurons of the hypothalamus and the limbic system. The expression of the MC3R in the developing rat brain increases suggesting that this receptor may mediate the neurotrophic actions of the melanocortin peptides. The MC3 receptor is also found in the gut and placenta, in adipose tissue and skeletal muscle. The MC3 receptor has been proposed to mediate the actions of MSH, in particular those of alpha-MSH and gamma-MSH peptides. MC3R appears to play a central role in mediating the effect of the melanocortin system on energy homeostasis. Alpha-MSH or synthetic agonists cause anorexia and weight loss. Agouti-related protein (AGRP), a physiological antagonist of MC3R and MC4R, can induce hyperphagia and obesity. MC3R is thought to regulate fat stores by a metabolic pathway. MC3R knockout mice (MC3R-/-) have increased fat mass, but not high body mass index, are hyperleptinaemic and develop mild hyperinsulinaemia. In contrast to MC3R, MC4R primarily controls food intake, suggesting that both MC3 and MC4 receptors may play a complementary role in weight control.

General readings

Muhlhausler BS, Adam CL, Marrocco E, Findlay PA, Roberts CT, McFarlane JR, Kauter KG, McMillen IC. Impact of glucose infusion on the structural and functional characteristics of adipose tissue and on hypothalamic gene expression for appetite regulatory neuropeptides in the sheep fetus during late gestation. J Physiol. 2005 Jan 20

19 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC3-R (N-term) antibody

TA303015 (1µg/ml) staining of Human Brain lysate (35µg protein in RIPA buffer).  Primary incubation was 1 hour.  Detected by chemiluminescence. Goat Aff - Purified Chimp, Hu WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC3-R antibody

Predicted band size: 36 kDa . Positive control: Mouse large intestine tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC3-R antibody

Predicted band size: 36 kDa . Positive control: Mouse large intestine lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC3-R antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1, 2. Anti-Melanocortin Receptor 3 (extracellular) antibody, (1:200). 3, 4. Anti-Melanocortin Receptor 3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC3-R antibody

Anti-MC3 Receptor antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Can, Eq, Hst, Hu, Ms, Por, Rt
50 µg / €379.00
  OriGene Technologies, Inc.

MC3-R control peptide

MC3-R
0.25 mg / €250.00
  Acris Antibodies GmbH

MC3-R (N-term) antibody

Western blot with AP10124PU-N at 1:500. Rabbit Aff - Purified Hu, Ms, Rt C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MC3-R Control Peptide

MC3-R
0.25 mg / €250.00
  Acris Antibodies GmbH

MC3-R antibody

MC3-R Rabbit Aff - Purified Hu, Ms, Rt C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MC3-R control peptide

MC3-R
0.1 mg / €250.00
  Acris Antibodies GmbH

MC3-R (C-term) antibody

MC3-R Rabbit Aff - Purified Hu, Ms, Rt C, IP, WB
0.25 mg / €420.00
  Acris Antibodies GmbH

MC3-R antibody

Western blot analysis of MC3R Antibody (Center) (AP18111PU-N) in K562 cell line lysates (35ug/lane). MC3R (arrow) was detected using the purified Pab. Rabbit Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MC3-R antibody

MC3-R Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MC3-R antibody

MC3R polyclonal antibody ( Cat # PAB6776 ) ( 1 µg/ml ) staining of human brain lysate ( 35 µg protein in RIPA buffer ) . Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

MC3-R antibody

Western Blot: Melanocortin 3 Receptor Antibody [NB100-1501] - NB100-1501(1ug/ml) staining of Human Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MC3-R

MC3-R Human
2 µg / €450.00
  Abnova Taiwan Corp.

MC3-R

MC3-R Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
2 µg / €290.00
  Abnova Taiwan Corp.

MC3-R

MC3-R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MC3-R

MC3-R Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

19 Item(s)

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