MC4-R antibody

Principal name

MC4-R antibody

Alternative names for MC4-R antibody

MC4R, Melanocortin receptor 4

SwissProt ID

O97504 (Pig), P32245 (Human), P56450 (Mouse), P70596 (Rat), Q9GLJ8 (Bovin)

Gene ID

4160 (MC4R), 17202 (Mc4r), 25635

Available reactivities

Bt (Bat), Can (Canine), Eq (Equine), GP (Guinea Pig), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Prim (Primate), Rt (Rat), Bear, Bov (Bovine), Rb (Rabbit), Sh (Sheep)

Available hosts

Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of MC4-R antibody

Melanocortin Receptor 4 (MC4R) is one of five members of the melanocortin receptor family, which belongs to the 7-transmembrane domain, G protein-coupled receptor (GPCR) superfamily. The ligands of these receptors, the melanocortins, are a group of structurally-related peptides comprising the a-, Ã?-, and ?-melanocyte-stimulating hormone (a-, Ã?-, ?-MSH) and the adrenocorticotropic hormone (ACTH), all of which are derived from post-translatiol processing of a common precursor peptide, proopiomelanocortin (POMC). One of the salient features of the melanocortin sigling system is the existence of two endogenous antagonists, proteins that bind specifically to the receptor and have an inhibitory effect. These antagonist proteins are termed agouti (or agouti sigling protein, ASP) and agouti-related protein (AGRP). All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti/ASP and AGRP) with differing affinities. The order of potency for MC4R activation is a-MSH = ACTH > Ã?-MSH >> ?-MSH. AGRP and agouti/ASP are both endogenous antagonists of MC4R. MC4R is widely expressed in the brain including the cortex, thalamus, hypothalamus, and brain stem. The best understood physiological role of MC4R is in the regulation of feeding behavior and the control of body weight. Indeed, mice with a targeted disruption of the MC4R gene display an obese phenotype characterized by increased adiposity, hyperphagia, and hyperleptiemia. Similarly, MC4R mutations in humans have been associated with severe childhood obesity including characteristics very similar to the MC4R knockout mouse phenotype. All these make MC4R an attractive drug target for the treatment of obesity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC4-R antibody

  Rabbit Polyclonal Anti-Melanocortin Receptor 4 (extracellular)  
Western blot analysis of rat brain lysates: 1. Anti-Melanocortin Receptor 4 (extracellular) antibody, (1:400). 2. Anti-Melanocortin Receptor 4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC4-R antibody

  Rabbit Polyclonal MC4R Antibody  
Western blot analysis of MC4R in rat brain tissue lysate with MC4R antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC4-R antibody

  Rabbit polyclonal anti-MC4R antibody  
Western blot analysis of extracts from MCF-7 cells, using MC4R antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC4-R antibody

  Anti-MC4R Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human lung cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded human lung cancer tissue using MC4R antibody at dilution 1/30, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC4-R antibody

  Anti-MC4R Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Cell membrane. Positive control: Human ovarian and lung cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human ovarian cancer tissue using MC4R antibody at dilution 1/50, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC4-R antibody

  Rabbit Polyclonal Anti-MC4R Antibody (N-Terminus)  
Anti-MC4 Receptor antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky, Ms
50 µg / €400.00
  OriGene Technologies, Inc.

MC4-R antibody

  Rabbit Polyclonal Anti-MC4R Antibody (Cytoplasmic Domain)  
Anti-MC4R / Melanocortin 4 Receptor antibody IHC of human brain neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bt, Can, Eq, GP, Hst, Hu, Por
50 µg / €400.00
  OriGene Technologies, Inc.

MC4-R antibody

Western blot (WB) analysis of MC4-R antibody (Cat.-No.: AP01319PU-N) in extracts from MCF-7 cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MC4-R (N-term Extracelll. Dom.) antibody

Formalin-Fixed, Paraffin-Embedded Human Brain stained with MC4-R antibody Cat.-No SP4387 after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bt, Can, Elephant, Eq, GP, Hst, Hu, Mky, Ms, Por, Prim, Rt ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

MC4-R antibody

Western blot analysis of extracts from MCF-7 cells, using MC4R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

MC4-R antibody

Western blot analysis of extracts from MCF-7 cells, using MC4R Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

MC4R - human gene knockout kit via CRISPR

MC4R - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MC4R - human gene knockout kit via CRISPR

MC4R - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MC4R - human gene knockout kit via CRISPR

MC4R - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MC4R - human gene knockout kit via CRISPR

MC4R - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc4r - mouse gene knockout kit via CRISPR

Mc4r - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mc4r - mouse gene knockout kit via CRISPR

Mc4r - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc4r - mouse gene knockout kit via CRISPR

Mc4r - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mc4r - mouse gene knockout kit via CRISPR

Mc4r - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MC4-R

  Recombinant protein of human melanocortin 4 receptor (MC4R)  
MC4-R Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells

Regular Price: 20 µg / €680.00

Special Price: 20 µg / €398.00

  OriGene Technologies, Inc.

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