MC5-R antibody

Principal name

MC5-R antibody

Alternative names for MC5-R antibody

MC-2, MC5R, Melanocortin receptor 5

SwissProt ID

P33032 (Human), P35345 (Rat), P41149 (Mouse), P56451 (Bovin)

Gene ID

4161 (MC5R), 17203

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Hst (Hamster), Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Rb (Rabbit), Rt (Rat), Sh (Sheep), Bear, Chimp (Chimpanzee)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of MC5-R antibody

Melanocortin Receptor 5 (MC5R) is one of five members of the melanocortin receptor family, which belongs to the 7-transmembrane domain, G-Protein Coupled Receptor (GPCR) superfamily. The ligands of these receptors, the melanocortins, are a group of structurally-related peptides comprising the a-, Ã?-, and ?-melanocyte-stimulating hormone (a-, Ã?-, ?-MSH) and the adrenocorticotropic hormone (ACTH), all of which are derived from post-translatiol processing of a common precursor peptide, proopiomelanocortin (POMC) 1,2,3. One of the salient features of the melanocortin sigling system is the existence of two endogenous antagonists, proteins that bind specifically to the receptor and have an inhibitory effect. These antagonist proteins are termed agouti (or agouti sigling protein, ASP) and agouti-related protein (AGRP) 1. All five melanocortin receptors bind their agonists (the melanocortins) and their endogenous antagonists (agouti/ASP and AGRP) with differing affinities. The order of potency for MC5R activation is α-MSH > ACTH = β-MSH >> γ-MSH while AGRP works as an endogenous antagonists of MC5R. MC5R is mostly expressed in peripheral tissues such as skeletal muscle, bone marrow, skin tissues particularly in sebaceous glands and exocrine glands such as salivary glands. The best understood function of Melanocortin Receptor 5 is in the regulation of exocrine glands since MC5R-deficient mice exhibit severely defective water repulsion and thermoregulation due to decreased production of sebaceous lipids.

General readings

Grieco P, Cai M, Han G, Trivedi D, Campiglia P, Novellino E, Hruby VJ.
Further structure-activity studies of lactam derivatives of MT-II and SHU-9119: their activity and selectivity at human melanocortin receptors 3, 4, and 5.
Peptides. 2007 Jun;28(6):1191-6. Epub 2007 Mar 1.
PMID: 17482720

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MC5-R antibody

Anti-MC5 Receptor antibody IHC of human testis, spermatogenic series. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

MC5-R (N-term) antibody

TA305847 (0.3ug/ml) staining of Mouse Muscle lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MC5-R antibody

Sample (30 ug of whole cell lysate). A: Hela. 10% SDS PAGE. TA308009 diluted at 1:1000. Rabbit IgG Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC5-R antibody

Western blot analysis of extracts from K562 cells, using MC5R antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC5-R antibody

Predicted cell location: Cytoplasm. Positive control: Human esophagus cancer tissue. Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using MC5R antibody at dilution 1/60, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC5-R antibody

Predicted band size: 37 kDa . Positive control: Mouse skeletal muscle tissue lysate. Recommended dilution: 1/500-2000 Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MC5-R antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-Melanocortin Receptor 5 antibody, (1:200). 3, 4. Anti-Melanocortin Receptor 5 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MC5-R (1st Extracell. Dom.) antibody

Anti-MC5 Receptor antibody IHC of human testis, spermatogenic series. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Bt, Can, Hst, Hu, Mky, Ms, Op, Platypus, Rb, Rt, Sh P
50 µg / €379.00
  OriGene Technologies, Inc.

MC5-R antibody

Anti-MC5 Receptor antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hst, Hu, Mky, Ms
50 µg / €379.00
  OriGene Technologies, Inc.

MC5-R antibody

Western blot (WB) analysis of MC5-R antibody (Cat.-No.: AP01320PU-N) in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

MC5-R antibody

Immunofluorescence analysis of MCF7 cells, using MC5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

MC5-R antibody

Immunofluorescence analysis of MCF7 cells, using MC5R Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

MC5-R antibody

Western Blot: MC5-R Antibody [NBP1-00915] - Western blot (WB) analysis of MC5-R (E308) antibody in extracts from K562 cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €420.00
  Novus Biologicals Inc.

MC5-R antibody

MC5-R Goat IgG Hu, Ms E, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MC5-R

MC5-R Human
2 µg / €450.00
  Abnova Taiwan Corp.

15 Item(s)

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