MCAF antibody

Principal name

MCAF antibody

Alternative names for MCAF antibody

ATF7IP, MCAF1, ATFa-associated modulator, ATF-interacting protein, P621, Activating transcription factor 7-interacting protein 1, MBD1-containing chromatin-associated factor 1

SwissProt ID

Q5ZIE8 (Chick), Q6VMQ6 (Human), Q7TT18 (Mouse)

Gene ID

55729 (ATF7IP), 54343 (Atf7ip)

Available reactivities

Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts


Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of MCAF antibody

Recruiter that couples transcriptiol factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptiol repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples D methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCAF antibody

Host: Rabbit; Target Name: Atf7ip; Sample Tissue: Mouse Lung lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Ms, Por, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

MCAF antibody

MCAF Rabbit Hu, Ms WB
0.1 ml / €400.00
  Abnova Taiwan Corp.

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