Alternative names for MCAF antibody
ATF7IP, MCAF1, ATFa-associated modulator, ATF-interacting protein, P621, Activating transcription factor 7-interacting protein 1, MBD1-containing chromatin-associated factor 1
Western blot / Immunoblot (WB), Paraffin Sections (P)
Background of MCAF antibody
Recruiter that couples transcriptiol factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Atf7ip can both act as an activator or a repressor depending on the context. It mediates MBD1-dependent transcriptiol repression, probably by recruiting complexes containing SETDB1. Atf7ip is required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples D methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Atf7ip may have ATPase activity.