MCHR1 / GPR24 antibody

Principal name

MCHR1 / GPR24 antibody

Alternative names for MCHR1 / GPR24 antibody

SLC1, MCH receptor 1, MCHR-1, MCH-R1, G-protein coupled receptor 24, Melanin-concentrating hormone receptor 1, Somatostatin receptor-like protein

SwissProt ID

P97639 (Rat), Q8JZL2 (Mouse), Q99705 (Human), Q9MZ01 (Pig)

Gene ID

2847 (MCHR1), 83567 (Mchr1)

Available reactivities

Bov (Bovine), Can (Canine), Eq (Equine), Hu (Human), Mky (Monkey), Por (Porcine), Ms (Mouse), Rt (Rat), Bear, Chimp (Chimpanzee)

Available hosts

Rabbit, Mouse

Available applications

Paraffin Sections (P), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Flow Cytometry (F)

Background of MCHR1 / GPR24 antibody

Melanin-concentrating hormone (MCH) is a 19 amino acid peptide origilly isolated from the salmon pituitary gland (in fish the length of the peptide is 17 amino acids). In rodents and humans the peptide is synthesized in the brain and is involved in a number of physiological effects, although it is best known for its central role in the control of appetite control. For example, central administration of MCH in mice leads to obesity and conversely, knockout of the MCH gene in mice yields lean animals with an increased metabolic rate and reduced body fat. MCH exerts its effects by binding MCHR1 and MCHR2, two receptors belonging to the superfamily of G-protein coupled receptors (GPCRs). Like all members of the family, MCHR1 and MCHR2 have seven transmembrane domains, an extracellular N-termil and intracellular C-termil tails. MCHR1 and MCHR2 activation both lead to an increase in intracellular Ca2+ concentration. In rat, MCHR1 expression is quite broad, and is strongly detected in the brain. Expression of the receptor is also seen in the eye, skeletal muscle, tongue, pituitary, intestine and lymphocytes. MCHR1 is also expressed in adipose tissue where it regulates leptin secretion. In human, MCHR1 is mostly localized to the brain and pituitary. MCHR2 displays similar localization to that of MCHR1 in the brain. As MCHR2 is a pseudogene in rodents, studying its function is quite challenging. In the brain, MCHR1 is localized in many areas that are known to be involved in various psychological disorders. Indeed, MCHR1-/- animals display antianxiety- and antidepressant-like behavior. Therefore, antagonizing the activity of MCHR1 could indeed serve as a means to treat depression and obesity.

General readings

Miyamoto-Matsubara, M., et al. Ann. N. Y. Acad. Sci. 1200, 112-119 (2010)
Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)
Miller, C.L., et al. Schizophr. Res. 113 (2-3), 259-267 (2009)
Gavalas, N.G., et al. Exp. Dermatol. 18(5):454-463(2009)
de Krom, M., et al. Biol. Psychiatry 65(7):625-630(2009)

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCHR1 / GPR24 antibody

Anti-MCHR1 antibody IHC of human Soft Tissue, Liposarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit IgG Purified Hu
50 µg / €345.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 (C-term) antibody

Sample (30 ug of whole cell lysate). A: IMR32 10% SDS PAGE. TA308652 diluted at 1:1000. Rabbit Aff - Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 antibody

Anti-SLC1 / MCHR1 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 15-30 ug/ml. Rabbit IgG Purified Chimp, Hu, Mky
50 µg / €345.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 (N-term extracel. dom.) antibody

Anti-MCHR1 antibody IHC of human Soft Tissue, Liposarcoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Can, Eq, Hu, Mky, Por P
50 µg / €345.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 (C-term) antibody

Anti-MCHR1 antibody IHC of human brain, substantia nigra. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bear, Bov, Can, Elephant, Eq, Hu, Mky, Ms, Por, Rt E, P
50 µg / €345.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 antibody

Western blot analysis of rat brain (lanes 1 and 4), mouse brain (lanes 2 and 5) and human SH-SY5Y (lanes 3 and 6) lysates: 1-3. Anti-Melanin-Concentrating Hormone Receptor 1 (extracellular) antibody, (1:200). 4-6. Anti-Melanin-Concentrating Hormone Receptor 1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

MCHR1 / GPR24 (C-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with MCHR1 / GPR24 Antibody (C-term) Cat.-No AP52635PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MCHR1 / GPR24 antibody

Western Blot analysis of MCHR1 expression in transfected 293T cell line (H00002847-T01) by MCHR1 MaxPab polyclonal antibody.

Lane 1: MCHR1 transfected lysate(46.00 KDa).
Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MCHR1 / GPR24 antibody

GPR24 monoclonal antibody (M01), clone 3D7 Western Blot analysis of GPR24 expression in HL-60 ( Cat # L014V1 ). Mouse IgG2a 3D7 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Purified E
0.1 mg / €290.00
  Novus Biologicals Inc.

MCHR1 / GPR24 antibody

MCHR1 / GPR24 Rabbit IgG Aff - Purified Rt WB
0.1 mg / €470.00
  Novus Biologicals Inc.

MCHR1 / GPR24 antibody

Immunohistochemistry-Paraffin: MCHR Antibody [NBP1-89738] - Immunohistochemistry-Paraffin: MCHR Antibody [NBP1-89738] Immunohistochemical staining of human skin shows strong cytoplasmic positivity in epidermal cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MCHR1 / GPR24

MCHR1 / GPR24 Human
10 µg / €540.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human Purified
10 µg / €380.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €380.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €510.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MCHR1 / GPR24

MCHR1 / GPR24 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Items 1 to 20 of 21 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn