MCM5 antibody

Principal name

MCM5 antibody

Alternative names for MCM5 antibody

CDC46 homolog, P1-CDC46, CDC46, DNA replication licensing factor MCM5, minichromosome maintenance complex component 5

SwissProt ID

P29496 (Yeast), P33992 (Human), P49718 (Mouse), Q0V8B7 (Bovin)

Gene ID

4174 (MCM5)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Rt (Rat), Chk (Chicken), Mky (Monkey), Rb (Rabbit), Eq (Equine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of MCM5 antibody

The mini-chromosome maintenance (MCM) family of proteins, including MCM2, MCM3, MCM4 (Cdc21), MCM5 (Cdc46), MCM6 (Mis5) and MCM7 (Cdc47), are regulators of DNA replication that act to ensure replication occurs only once in the cell cycle. Expression of MCM proteins increases during cell growth, peaking at G1 to S phase. The MCM proteins each contain an ATP-binding motif, which is predicted to mediate ATP-dependent opening of double-stranded DNA. MCM proteins are regulated by E2F transcription factors, which induce MCM expression, and by protein kinases, which interact with MCM proteins to maintain the postreplicative state of the cell. MCM2/MCM4 complexes function as substrates for Cdc2/cyclin B in vitro. Cleavage of MCM3, which can be prevented by caspase inhibitors, results in the inactivation of the MCM complex (composed of at least MCM proteins 2 - 6) during apoptosis. A complex composed of MCM4, MCM6 and MCM7 has been shown to be involved in DNA helicase activity; and MCM5 is involved in IFN-γ-induced Stat1α transcription activation.

General readings

Ohtani,K., et al., (1999) Oncogene 18 (14), 2299-2309

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCM5 antibody

Jurkat cell nuclear extract was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-MCM5 antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

Western blot analysis of extracts from HepG2 cells, using MCM5 antibody (#TA312325).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

Western blot analysis of extracts from A549 cells, using MMP-11 antibody (#TA312326).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

Western blot analysis of extracts of various cell lines, using MCM5 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

WB Suggested Anti-MCM5 Antibody Titration: 2.5 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Eq, Hu, Ms, Rb, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

Western blot analysis on HepG2 cell lysate using MCM5 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-5: HepG2 cells, K562 cells, Jurkat cells, 231 cells, hela cells, Primary antibody: (MCM5 Antibody) at dilution 1/475, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2.1G2.A7.C12 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2.5A12.A12.A11 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2.7A3.F12.A7 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse A2.7B10.A12.B8 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2.12E7.B12.A8 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgM A4.8D6.H10.D9 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG1 6G8A4F10 Purified ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2.2C9.C9.C11. Purified ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2 12A7 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2 4B4 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse A2 9B4 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG2 A2 2C11 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM5 antibody

MCM5 Mouse IgG A2 10A12 Purified Hu ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

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