MCM6 antibody

Principal name

MCM6 antibody

Alternative names for MCM6 antibody

Mis5, P105MCM, minichromosome maintenance complex component 6, DNA replication licensing factor MCM6

SwissProt ID

P53091 (Yeast), P97311 (Mouse), Q14566 (Human), Q2KIZ8 (Bovin), Q62724 (Rat)

Gene ID

4175 (MCM6), 17219 (Mcm6)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MCM6 antibody

The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

General readings

1. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes,
M., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the
lactase gene. Am. J. Hum. Genet. 74: 1111-1120, 2004.
2. Coelho, M., Luiselli, D., Bertorelle, G., Lopes, A. I., Seixas, S., Destro-Bisol, G., Rocha,
J. Microsatellite variation and evolution of human lactase persistence. Hum. Genet. 117: 329-339,
2005.
3. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Jarvela, I. Identification of a
variant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCM6 antibody

  Rabbit Polyclonal anti-MCM6 Antibody  
Hela (left lane) and NIH-3T3 (right lane) cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-MCM6 antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

  Rabbit anti-MCM6 Polyclonal Antibody  
Western blot analysis of extracts of 293 cell lines , using MCM6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

  Rabbit Polyclonal MCM6 Antibody  
Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-MCM6 rabbit polyclonal antibody. (TA590213) Rabbit IgG Purified Can, Hu, Mky, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

  Rabbit Polyclonal Anti-MCM6 Antibody  
WB Suggested Anti-MCM6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

  Rabbit Polyclonal Anti-MCM6 Antibody  
WB Suggested Anti-MCM6 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

  Rabbit Polyclonal Anti-MCM6 Antibody  
Gel: 10%SDS-PAGE, Lysate: 40 ug, Lane 1-5: 293T cells, A549 cells, Raji cells, K562 cells, NIH/3T3 cells, Primary antibody: (MCM6 Antibody) at dilution 1/433.3, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 5 seconds Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCM6 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue reacted with MCM6 Antibody (N-term) Cat.-No AP52640PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MCM6 antibody

Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti Human MCM6 (SP2108P) Rabbit Aff - Purified Hu WB
0.1 mg / €450.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MCM6 - human gene knockout kit via CRISPR

MCM6 - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MCM6 - human gene knockout kit via CRISPR

MCM6 - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

MCM6 - human gene knockout kit via CRISPR

MCM6 - human gene knockout kit via CRISPR Human Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

MCM6 - human gene knockout kit via CRISPR

MCM6 - human gene knockout kit via CRISPR Human RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mcm6 - mouse gene knockout kit via CRISPR

Mcm6 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Mcm6 - mouse gene knockout kit via CRISPR

Mcm6 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mcm6 - mouse gene knockout kit via CRISPR

Mcm6 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Mcm6 - mouse gene knockout kit via CRISPR

Mcm6 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MCM6

  Recombinant protein of human minichromosome maintenance complex component 6 (MCM6)  
MCM6 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MCM6 overexpression lysate

MCM6 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MCM6 (mGFP-tagged) - Human minichromosome maintenance complex component 6 (MCM6), 200 uL, >10^7 TU/mL

Lenti ORF particles, MCM6 (mGFP-tagged) - Human minichromosome maintenance complex component 6 (MCM6), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, MCM6 (Myc-DDK tagged) - Human minichromosome maintenance complex component 6 (MCM6) , 200 uL, >10^7 TU/mL

Lenti ORF particles, MCM6 (Myc-DDK tagged) - Human minichromosome maintenance complex component 6 (MCM6) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

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