MCM6 antibody

Principal name

MCM6 antibody

Alternative names for MCM6 antibody

Mis5, P105MCM, minichromosome maintenance complex component 6, DNA replication licensing factor MCM6

SwissProt ID

P53091 (Yeast), P97311 (Mouse), Q14566 (Human), Q2KIZ8 (Bovin), Q62724 (Rat)

Gene ID

4175 (MCM6)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Can (Canine), Rt (Rat), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), PLA/Proximity ligation assay (PLA), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C), ChIP assay (ChIP)

Background of MCM6 antibody

The protein encoded by the MCM6 gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of the complex by CDC2 kinase reduces the helicase activity, suggesting a role in the regulation of DNA replication.

General readings

1. Bersaglieri, T., Sabeti, P. C., Patterson, N., Vanderploeg, T., Schaffner, S. F., Drake, J. A., Rhodes,
M., Reich, D. E., Hirschhorn, J. N. Genetic signatures of strong recent positive selection at the
lactase gene. Am. J. Hum. Genet. 74: 1111-1120, 2004.
2. Coelho, M., Luiselli, D., Bertorelle, G., Lopes, A. I., Seixas, S., Destro-Bisol, G., Rocha,
J. Microsatellite variation and evolution of human lactase persistence. Hum. Genet. 117: 329-339,
2005.
3. Enattah, N. S., Sahi, T., Savilahti, E., Terwilliger, J. D., Peltonen, L., Jarvela, I. Identification of a
variant associated with adult-type hypolactasia. Nature Genet. 30: 233-237, 2002.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCM6 antibody

Hela (left lane) and NIH-3T3 (right lane) cell lysate was resolved by electrophoresis, transferred to nitrocellulose and probed with rabbit anti-MCM6 antibody. Proteins were visualized using a donkey anti-rabbit secondary antibody conjugated to HRP and a chemiluminescence system. Rabbit IgG Aff - Purified Hu, Ms P, WB
0.2 ml / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

Western blot analysis of extracts of 293 cell lines , using MCM6 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

Immunohistochemical staining of paraffin-embedded Human endometrium tissue using anti-MCM6 rabbit polyclonal antibody. (TA590213) Rabbit IgG Purified Can, Hu, Mky, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

Immunoperoxidase of purified MaxPab antibody to MCM6 on formalin-fixed paraffin-embedded human lymph node. [antibody concentration 3 ug/ml] Mouse Purified Hu E(detection), ICC/IF, P, WB
50 µg / €370.00
  Abnova Taiwan Corp.

MCM6 antibody

WB Suggested Anti-MCM6 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:62500; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
50 µg / €325.00
  OriGene Technologies, Inc.

MCM6 antibody

WB Suggested Anti-MCM6 Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MCM6 (N-term) antibody

Immunohistochemistry analysis in formalin fixed and paraffin embedded human tonsil tissue reacted with MCM6 Antibody (N-term) Cat.-No AP52640PU-N, which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Rabbit Ig Aff - Purified Hu P, WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MCM6 antibody

Detection of human MCM6 in a RIPA extract of HeLa cells by Western Blotting using Rabbit anti Human MCM6 (SP2108P) Rabbit Aff - Purified Hu WB
0.1 mg / €450.00
  Acris Antibodies GmbH

MCM6 antibody

MCM6 polyclonal antibody (A01), Lot # 050919JC01 Western Blot analysis of MCM6 expression in SJCRH30 ( Cat # L027V1 ). Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

MCM6 antibody

MCM6 Rabbit Purified Hu E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MCM6 antibody

MCM6 Mouse IgG2a 7D8 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MCM6 antibody

Human Intestine; MCM6 antibody - C-terminal region (ARP36650_P050) in Human Intestine cells using Immunohistochemistry Rabbit Aff - Purified Can, Hu P, WB
50 µg / €350.00
  AVIVA Systems Biology

MCM6 antibody

Human Lung; MCM6 antibody - C-terminal region (ARP36650_T100) in Human Lung cells using Immunohistochemistry Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €310.00
  AVIVA Systems Biology

MCM6 antibody

MCM6 Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €290.00
  Boster Immunoleader

MCM6 antibody

ELISA: MCM6 Antibody [28370002] Rabbit Hu E
50 µg / €400.00
  Novus Biologicals Inc.

MCM6 antibody

Western Blot: MCM6 Antibody [NB100-251] - Detection of Human MCM6 by Western Blot.  Sample: Whole cell lysate (60 mcg) from HeLa cells. Antibody: Affinity purified goat anti-MCM6 (Cat. No. NB100-251) used at 0.25 mcg/ml. Detection: Chemiluminescence. Rabbit Aff - Purified Hu PLA, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

MCM6 antibody

Western Blot: MCM6 Antibody [NB100-291] - Detection of Human MCM6 by Western Blot. Sample: RIPA extract (50 mcg) from HeLa cells. Antibody: Affinity purified rabbit anti-MCM6 (Cat. No. NB100-291) used at 0.2 mcg/ml. Detection: Chemiluminescence. Rabbit Aff - Purified Hu WB
0.1 mg / €440.00
  Novus Biologicals Inc.

MCM6 antibody

Immunohistochemistry-Paraffin: MCM6 Antibody [NB100-2162] - Detection of Human MCM6 by Immunohistochemistry.  Sample: FFPE section of human colon adenocarcinoma.   Antibody: Affinity purified goat anti-MCM6 used at a dilution of 1:250.  Detection: DAB Rabbit Aff - Purified Hu, Ms P
0.1 ml / €500.00
  Novus Biologicals Inc.

MCM6 antibody

Western Blot: MCM6 Antibody [NBP1-58075] - This Anti-MCM6 antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 0.25ug/ml. Rabbit Aff - Purified Can, Hu P, WB
50 µg / €440.00
  Novus Biologicals Inc.

MCM6 antibody

Immunohistochemistry-Paraffin: MCM6 Antibody [NBP1-82642] - Immunohistochemical staining of human lymph node shows strong nuclear positivity in reaction center cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

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