MCSP antibody

Principal name

MCSP antibody

Alternative names for MCSP antibody

CSPG4, Chondroitin sulfate proteoglycan 4, NG2, Melanoma chondroitin sulfate proteoglycan, Melanoma-associated chondroitin sulfate proteoglycan

SwissProt ID

Q00657 (Rat), Q6UVK1 (Human), Q8VHY0 (Mouse)

Gene ID

1464 (CSPG4)

Available reactivities

Hu (Human), Por (Porcine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Frozen Sections (C), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of MCSP antibody

NG2 (also known as melanoma-associated chondroitin sulfate proteoglycan 4, MCSP, MCSPG, MSK16 and MEL-CSPG) stabilizes cell-substratum interactions during early events of melanoma cell spreading on endothelial basement membranes. NG2 may facilitate primary melanoma progression by enhancing the activation of key signaling pathways important for tumor invasion and growth. Threonine 2256 phosphorylation of rat NG2 (Threonine 2252 phosphorylation of human NG2) leads to redistribution of NG2 on the surface of astrocytomas, polarization of the cell and a significant increase in cell motility. NG2 acts as a co-receptor for spreading and focal contact formation in association with Alpha 4 Beta1 integrin in malignant melanoma cells. NG2 is present on blood vessels throughout the rat embryo. Microvessels within the rat CNS express NG2 on endothelial cells, and outside the CNS, NG2 is present on smooth muscle cells. NG2 is a novel marker for epidermal stem cells that contributes to their patterned distribution by promoting stem cell clustering.

General readings

This clone has been used in:Kupsch JM et al. Isolation of human tumor-specific antibodies by selection of an antibody phage library on melanoma cells. Clin Cancer Res 5:925-31 (1999). PubMed PMID: 10213230
Kupsch JM et al. Generation and selection of monoclonal antibodies, single-chain Fv and antibody fusion phage specific for human melanoma-associated antigens. Melanoma Res 5:403-11 (1995). PubMed PMID: 8589614

5 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCSP antibody

Western Blot: NG2 Antibody (LHM 2) [TA336295] - Western blot analysis of NG2 expression in HeLa whole cell lysate. Mouse IgG1 LHM 2 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MCSP antibody

Immunohistochemistry-Paraffin: NG2 Antibody [NBP1-21361] - Primary cultured trabecular meshwork cells from porcine eye. Left non stretched TM cells; Right 24 hours stretched TM cells. Annonymous Customer Reported Findings. Rabbit IgG Aff - Purified Hu, Por IP, P, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MCSP antibody

Immunohistochemistry-Paraffin: NG2 Antibody [NBP1-89682] Immunohistochemical staining of human small intestine shows strong cytoplasmic positivity, with a granular pattern, in glandular cells. Rabbit IgG Aff - Purified Hu P
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MCSP

MCSP Human in vitro transl.
2 µg / €300.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

CSPG4 overexpression lysate

CSPG4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

5 Item(s)

per page
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