MCTS1 antibody

Principal name

MCTS1 antibody

Alternative names for MCTS1 antibody

Malignant T cell amplified sequence 1, MCTS1, MCT1, MCT-1

SwissProt ID

Q2KIE4 (Bovin), Q4G009 (Rat), Q9DB27 (Mouse), Q9ULC4 (Human)

Gene ID

28985 (MCTS1), 68995 (Mcts1)

Available reactivities

Ms (Mouse), Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog, GP (Guinea Pig), Por (Porcine), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of MCTS1 antibody

Malignant T cell amplified sequence 1 (MCTS1) is an anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer; and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.

General readings

Herbert G.B., et al. (2001) Oncogene. 20:6777-6783Shi B., et al. (2003) Blood. 102:297-302

  1. Quick-Filters:
  2. Highly Validated (3)
  3. Overnight Delivery (1)

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCTS1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA502418) Mouse IgG2a OTI 2G2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502424) Mouse IgG2a OTI2F9 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA502506) Mouse IgG2a OTI 5B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

WB Suggested Anti-MCTS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: COLO205 cell lysateMCTS1 is supported by BioGPS gene expression data to be expressed in COLO205 Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MCTS1 (3-14) antibody

Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bear, Bov, Bt, Can, Chk, Elephant, Fi, Frog, Hu, Mky, Ms, Op, Platypus, Por, Prim, Rt, Tr, Xen E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MCTS1 (N-term) antibody

Western blot analysis of MCT-1 antibody (N-term) (AP17555PU-N) in mouse bladder tissue lysates (35ug/lane). MCTS1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

MCTS1 antibody

MCTS1 Mouse IgM 1G1-2A2 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

MCTS1 antibody

MCTS1 Rabbit Ms WB
0.1 ml / €560.00
  Abnova Taiwan Corp.

MCTS1 antibody

Human COLO205; WB Suggested Anti-MCTS1 Antibody Titration: 0.2-1 ug/ml. ELISA Titer: 1:312500. Positive Control: COLO205 cell lysate. MCTS1 is supported by BioGPS gene expression data to be expressed in COLO205.; MCTS1 antibody - N-terminal region (ARP40751_P050) in Human COLO205 cells using Western Blot Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €350.00
  AVIVA Systems Biology

MCTS1 antibody

Western Blot: WWOX1 + 4 Antibody [NB300-692] - Western Blot Analysis of MCT in transfected 3T3 cells at 1:600. Rabbit Aff - Purified Ms WB
0.1 ml / €340.00
  Novus Biologicals Inc.

MCTS1 antibody

Western Blot: MCT1 Antibody [NBP1-58236] - This Anti-MCTS1 antibody was used in Western Blot of COLO205     tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu WB
50 µg / €440.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MCTS1 (transcript variant 1)

MCTS1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MCTS1 (1-181, His-tag)

MCTS1 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

MCTS1 (1-181, His-tag)

MCTS1 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

MCTS1

MCTS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €380.00
  Abnova Taiwan Corp.

MCTS1

MCTS1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €510.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    

MCTS1 overexpression lysate

MCTS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

17 Item(s)

per page
  • LinkedIn