MCTS1 antibody

Principal name

MCTS1 antibody

Alternative names for MCTS1 antibody

Malignant T cell amplified sequence 1, MCTS1, MCT1, MCT-1

SwissProt ID

Q2KIE4 (Bovin), Q4G009 (Rat), Q9DB27 (Mouse), Q9ULC4 (Human)

Gene ID

28985 (MCTS1), 68995 (Mcts1), 302500

Available reactivities

Bt (Bat), Bov (Bovine), Can (Canine), Chk (Chicken), Fi (Fish), Frog, Hu (Human), Mky (Monkey), Ms (Mouse), Op (Opossum), Por (Porcine), Prim (Primate), Rt (Rat), Xen (Xenopus), Tr (Turkey), Bear, Ze (Zebrafish), African clawed frog, GP (Guinea Pig), Rb (Rabbit)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P)

Background of MCTS1 antibody

Malignant T cell amplified sequence 1 (MCTS1) is an anti-oncogene that plays a role in cell cycle regulation; decreases cell doubling time and anchorage-dependent growth; shortens the duration of G1 transit time and G1/S transition. When constituvely expressed, MCTS1 increases CDK4 and CDK6 kinases activity and CCND1/cyclin D1 protein level, as well as G1 cyclin/CDK complex formation. MCTS1 plays a role as translation enhancer; and recruits the density-regulated protein/DENR and binds to the cap complex of the 5'-terminus of mRNAs, subsequently altering the mRNA translation profile; MCTS1 up-regulates protein levels of BCL2L2, TFDP1, MRE11A, CCND1 and E2F1, while mRNA levels remains constant. MCTS1 hyperactivates DNA damage signaling pathway; increased gamma-irradiation-induced phosphorylation of histone H2AX, and induces damage foci formation. MCTS1 increases the overall number of chromosomal abnormalities such as larger chromosomes formation and multiple chromosomal fusions when over-expressed in gamma-irradiated cells. MCTS1 may play a role in promoting lymphoid tumor development: lymphoid cell lines over-expressing MCTS1 exhibit increased growth rates and display increased protection against apoptosis. MCTS1 may contribute to the pathogenesis and progression of breast cancer via promotion of angiogenesis through the decline of inhibitory THBS1/thrombospondin-1, and inhibition of apoptosis. MCTS1 is involved in the process of proteosome degradation to down-regulate Tumor suppressor p53/TP53 in breast cancer cell; MCTS1 positively regulates phosphorylation of MAPK1 and MAPK3.

General readings

Herbert G.B., et al. (2001) Oncogene. 20:6777-6783Shi B., et al. (2003) Blood. 102:297-302

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MCTS1 antibody

  MCTS1 mouse monoclonal antibody, clone OTI 2G2 (formerly 2G2)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA502418) Mouse IgG2a OTI 2G2 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

  MCTS1 mouse monoclonal antibody, clone OTI2F9 (formerly 2F9)  
Immunohistochemical staining of paraffin-embedded Human colon tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA502424) Mouse IgG2a OTI2F9 Purified Hu P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

  MCTS1 mouse monoclonal antibody, clone OTI 5B5 (formerly 5B5)  
Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-MCTS1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA502506) Mouse IgG2a OTI 5B5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MCTS1 antibody

  Rabbit Polyclonal Anti-MCTS1 Antibody  
WB Suggested Anti-MCTS1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1: 312500; Positive Control: COLO205 cell lysateMCTS1 is supported by BioGPS gene expression data to be expressed in COLO205 Rabbit IgG Purified Bov, Can, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

MCTS1 (3-14) antibody

Prostate: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Bov, Can, Chk, Elephant, Hu, Ms, Platypus, Por, Xen, Ze E, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MCTS1 (N-term) antibody

Western blot analysis of MCT-1 antibody (N-term) (AP17555PU-N) in mouse bladder tissue lysates (35ug/lane). MCTS1 (arrow) was detected using the purified Pab. Rabbit Hu, Ms WB

Regular Price: 0.4 ml / €370.00

Special Price: 0.4 ml / €231.00

  Acris Antibodies GmbH

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MCTS1 (transcript variant 1)

  Recombinant protein of human malignant T cell amplified sequence 1 (MCTS1), transcript variant 1  
MCTS1 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

MCTS1 (1-181, His-tag)

MCTS1 Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH

MCTS1 (1-181, His-tag)

MCTS1 Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH

Lysates

Catalog No.    

MCTS1 overexpression lysate

MCTS1 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, MCTS1 (mGFP-tagged) - Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 1, 200 uL, >10^7 TU/mL

Lenti ORF particles, MCTS1 (mGFP-tagged) - Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 1, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, MCTS1 (mGFP-tagged)-Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MCTS1 (mGFP-tagged)-Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, MCTS1 (Myc-DDK tagged) - Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 1 , 200 uL, >10^7 TU/mL

Lenti ORF particles, MCTS1 (Myc-DDK tagged) - Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 1 , 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Lenti ORF particles, MCTS1 (Myc-DDK-tagged)-Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 2, 200 uL, >10^7 TU/mL

Lenti ORF particles, MCTS1 (Myc-DDK-tagged)-Human malignant T cell amplified sequence 1 (MCTS1), transcript variant 2, 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mcts1 (GFP-tagged) - Mouse malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mcts1 (GFP-tagged) - Mouse malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mcts1 (Myc-DDK-tagged) - Mouse malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mcts1 (Myc-DDK-tagged) - Mouse malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Mcts1 (GFP-tagged ORF) - Rat malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mcts1 (GFP-tagged ORF) - Rat malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL  
200 µl / €880.00
  OriGene Technologies, Inc.

Lenti ORF particles, Mcts1 (Myc-DDK-tagged ORF) - Rat malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL

Lenti ORF particles, Mcts1 (Myc-DDK-tagged ORF) - Rat malignant T cell amplified sequence 1 (Mcts1), 200 uL, >10^7 TU/mL  
200 µl / €780.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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