MD-2 antibody

Principal name

MD-2 antibody

Alternative names for MD-2 antibody

Lymphocyte antigen 96, ESOP-1, LY96, ESOP1, MD2

SwissProt ID

P58754 (Bovin), Q9JHF9 (Mouse), Q9Y6Y9 (Human)

Gene ID

23643 (LY96), 3236437 (Q5HIC3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Functional assay (FN), Flow Cytometry (F)

Background of MD-2 antibody

TLRs belong to a family of proteins that specifically recognizes and senses microbial products. They are highly conserved throughout evolution and act as innate immune recognition receptors against many pathogens. TLR4 is a functional receptor for gram-negative bacterial lipopolysaccharides (LPS). TLR4 associates with MD-2 which is absolutely required for LPS-induced activation of TLR4.
MD-2 exists as a cell surface protein in association with TLR4. It also exists as secreted forms consisting of MD-2 monomers and multimers (sMD-2). Circulating sMD-2 is mainly present as a doublet of ~20 and 25 kD, representing differentially glycosylated forms. Unlike TLR4, sMD-2 binds directly LPS without the need of soluble CD14 (sCD14). However, LPS-MD-2 interactions are increased when LPS is pretreated with CD14. Only monomeric sMD-2 is biologically active and able to associate with TLR4 and LPS. sMD-2 circulates in plasma of healthy individuals as a non-active, polymeric protein. In septic plasma, the total amount of sMD-2 was strongly elevated and contained both sMD-2 polymers and monomers. Soluble MD-2 is proposed to be an important mediator of organ inflammation during sepsis. During experimental human endotoxemia, the monomeric and total sMD-2 content in plasma increased with the kinetics of an acute phase protein. This parallels enhanced TLR4 costimulatory activity. In vitro studies revealed that sMD-2 release appears to be restricted to endothelial and dendritic cells.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MD-2 antibody

Western blot analysis of extracts of various cell lines, using LY96 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

MD-2 antibody

Western blot analysis of MD-2 in mouse spleen cell lysate with MD-2 antibody at 1 ug/ml. Rabbit IgG Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MD-2 (2-160) antibody

Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 ug/mL. Mouse IgG 9F1B1 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MD-2 (2-160) antibody

Western blot analysis of (A) 25 and (B) 125 ng of MD-2 recombinant protein with MD-2 antibody at 1 ug/mL. Mouse IgG 1A2E3 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MD-2 antibody

Immunohistochemistry: MD2 Antibody [TA336439] - IHC staining of normal human brain using 100-56655 (MD-2)at 10 ug/ml. Rabbit Purified Hu, Ms, Rt C, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MD-2 antibody

MD-2 Mouse IgG2b 18H10 FITC Hu FN
0.1 mg / €440.00
  Acris Antibodies GmbH

MD-2 antibody

MD-2 Mouse IgG2b 18H10 Purified Hu FN
0.1 mg / €370.00
  Acris Antibodies GmbH

MD-2 antibody

MD-2 Mouse IgG1 4H1 FITC Hu E, FN, ICC/IF, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

MD-2 antibody

MD-2 Mouse IgG1 4H1 Purified Hu E, FN, ICC/IF, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

MD-2 antibody

Western blot analysis of MD-2 in mouse spleen cell lysate with MD -2 antibody at 1 µg/ml. Rabbit IgG Purified Hu, Ms, Rt C, WB
0.1 mg / €370.00
  Acris Antibodies GmbH

MD-2 Control Peptide

MD-2
50 µg / €160.00
  Acris Antibodies GmbH

MD-2 antibody

LY96 MaxPab polyclonal antibody. Western Blot analysis of LY96 expression in human liver. Mouse Serum Hu E(detection), WB
50 µl / €370.00
  Abnova Taiwan Corp.

MD-2 antibody

LY96 MaxPab polyclonal antibody. Western Blot analysis of LY96 expression in human liver. Mouse Purified Hu E(detection), WB
50 µg / €370.00
  Abnova Taiwan Corp.

MD-2 antibody

LY96 MaxPab rabbit polyclonal antibody. Western Blot analysis of LY96 expression in mouse spleen. Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €380.00
  Abnova Taiwan Corp.

MD-2 antibody

Immunohistochemistry of LY96 in human spleen with LY96 monoclonal antibody, clone 9F1B1 ( Cat # MAB2752 ) at 2.5 µg/ml. Mouse IgG 9F1B1 Hu, Ms P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MD-2 antibody

Immunohistochemistry of LY96 in human spleen with LY96 monoclonal antibody, clone 1A2E3 ( Cat # MAB2753 ) at 2.5 µg/ml. Mouse IgG 1A2E3 Hu, Ms, Rt P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MD-2 antibody

Western blot analysis of LY96 in mouse spleen tissue lysate with LY96 polyclonal antibody ( Cat # PAB10121 ) at 1 µg/ml. Hu, Ms, Rt
0.1 mg / €470.00
  Abnova Taiwan Corp.

MD-2 (C-term) antibody

Human PANC1; WB Suggested Anti-LY96 Antibody. . Titration: 1.0 ug/ml. . Positive Control: PANC1 Whole Cell; LY96 antibody - C-terminal region (ARP61217_P050) in Human PANC1 cells using Western Blot Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MD-2 antibody

MD-2 Mouse 9F1B1 Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

MD-2 antibody

MD-2 Mouse 1A2E3 Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

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