MDC1 antibody

Principal name

MDC1 antibody

Alternative names for MDC1 antibody

MDC1, KIAA0170, NFBD1, Mediator of DNA damage checkpoint protein 1

SwissProt ID

Q14676 (Human), Q5PSV9 (Mouse), Q5U2M8 (Rat), Q767L8 (Pig)

Gene ID

9656 (MDC1), 5096569 (add)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chimp (Chimpanzee), Can (Canine), GP (Guinea Pig)

Available hosts

Rabbit, Sheep, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), PLA/Proximity ligation assay (PLA), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of MDC1 antibody

MDC1 (Mediator of DNA damage checkpoint protein 1) plays a role in checkpoint mediated cell cycle arrest in response to DNA damage, both within S phase and G2/M. It is thought to act as a scaffold protein during the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage that are marked by phosphorylation of histone H2A.X on S139. MDC1 is also involved in downstream events subsequent to the recruitment of these proteins. MDC1 has tandem repeat BRCT domains that are required for localisation to chromatin that flanks sites marked by S139 phosphorylated histone H2A.X. MDC1 is phosphorylated following exposure to ionising radiation (IR), ultraviolent radiation (UV), and hydroxyurea (HU). MDC1 is also phosphorylated during G2/M and during activation of the mitotic spindle checkpoint.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MDC1 antibody

Predicted cell location: Cytoplasm,Nucleus. Positive control: Human brain tissue. Recommended dilution: 1/100-300  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using MDC1 antibody at dilution 1/80, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MDC1 antibody

MDC1 Mouse IgG1 P2B11 Purified Bov, Chimp, Hu, Ms WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MDC1 antibody

WB Suggested Anti-MDC1 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:12500; Positive Control: HepG2 cell lysateMDC1 is strongly supported by BioGPS gene expression data to be expressed in Human HepG2 cells Rabbit IgG Purified Can, GP, Hu WB
50 µg / €325.00
  OriGene Technologies, Inc.

MDC1 pSer513 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using MDC1 (Phospho-Ser513) antibody AP55824PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
0.1 ml / €340.00
  Acris Antibodies GmbH

MDC1 pSer513 antibody

Immunohistochemical analysis of paraffin-embedded human brain tissue using MDC1 (Phospho-Ser513) antibody AP55824PU-N (left)or the same antibody preincubated with blocking peptide (right). Rabbit Aff - Purified Hu P
50 µl / €270.00
  Acris Antibodies GmbH

MDC1 Control Peptide

MDC1 Purified
50 µg / €190.00
  Acris Antibodies GmbH

MDC1 antibody

MDC1 Rabbit Aff - Purified Hu E, WB
0.1 mg / €440.00
  Acris Antibodies GmbH

MDC1 antibody

MDC1 Sheep Serum Hu ICC/IF, WB
0.1 ml / €330.00
  Acris Antibodies GmbH

MDC1 antibody

Western blot analysis of MDC1 in 30 µgs of Jurkat cell lysate using MDC1 polyclonal antibody ( Cat # PAB0366 ) at 1 : 1000 dilution. Rabbit Hu WB
0.2 ml / €400.00
  Abnova Taiwan Corp.

MDC1 antibody

Western blot analysis of extract from 293T ( lane 1 ) and HeLa cells ( lane 2 ) , using MDC1 polyclonal antibody ( Cat # PAB8487 ) . Rabbit Hu WB
25 µg / €660.00
  Abnova Taiwan Corp.

MDC1 antibody

MDC1 Hu
0.1 mg / €560.00
  Abnova Taiwan Corp.

MDC1 pSer513 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using MDC1 (Phospho-Ser513) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
50 µg / €205.00
  Assay Biotech

MDC1 pSer513 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using MDC1 (Phospho-Ser513) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, P
0.1 mg / €310.00
  Assay Biotech

MDC1 (C-term) antibody

MDC1 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

MDC1 antibody

MDC1 Rabbit Aff - Purified Hu WB
25 µg / €630.00
  Funakoshi Co., Ltd.

MDC1 antibody

Western Blot: MDC1 Antibody [NB100-395] - Detection of Human MDC1 by Western Blot.Samples: A) Nuclear extract (50 mcg) from HeLa cells. B) Whole cell lysate from HEK 293 cells. Antibodies: A) Affinity purified rabbit anti-MDC1 antibody NB100-395 used at the indicated concentrations for WB. B) Affinity purified rabbit anti-MDC1 antibodies NB100-396 and NB100-397 used at 3.3 mcg/mg lysate for IP followed by WB using NB100-196 at 0.1 mcg/ml. Detection: Chemiluminescence with exposure times less than 5 min. Rabbit Purified Hu ICC/IF, PLA, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MDC1 antibody

Western Blot and Immunoprecipitation: MDC1 Antibody [NB100-396] - Detection of Human MDC1 NB100-396. Affinity purified rabbit anti-MDC1 antibodies NB100-396 and NB100-397. Rabbit Purified Hu IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MDC1 antibody

Western Blot and Immunoprecipitation: MDC1 Antibody [NB100-397] - Detection of Human MDC1 NB100-387. Affinity purified rabbit anti-MDC1 antibodies NB100-396 and NB100-397. Rabbit Purified Hu ICC/IF, IP, WB
0.1 ml / €440.00
  Novus Biologicals Inc.

MDC1 antibody

Immunohistochemistry-Paraffin: MDC1 Antibody [NBP1-84860] - Immunohistochemical staining of human colon shows strong nuclear and membranous positivity in glandular cells. Rabbit IgG Aff - Purified Hu ICC/IF, P
0.1 ml / €500.00
  Novus Biologicals Inc.

19 Item(s)

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