MDM4 antibody

Principal name

MDM4 antibody

Alternative names for MDM4 antibody

MDMX, MDM-4, Double minute 4 protein, Mdm2-like p53-binding protein, p53-binding protein Mdm4

SwissProt ID

O15151 (Human), O35618 (Mouse), Q2HJ21 (Bovin), Q5XIN1 (Rat), Q7ZUW7 (Danre), Q7ZYI3 (Xenla)

Gene ID

4194 (MDM4), 17248 (Mdm4), 304798

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP), EPair for Elisa (EPair), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MDM4 antibody

MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

General readings

Gilkes,D.M., (2008) Mol. Cell. Biol. 28 (6), 1999-2010

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4B5 (formerly 4B5)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505706) Mouse IgG1 OTI4B5 Purified Hu ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI1D11 (formerly 1D11)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505722) Mouse IgG2a OTI1D11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4G5 (formerly 4G5)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505723) Mouse IgG2b OTI4G5 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI3H2 (formerly 3H2)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505735) Mouse IgG2b OTI3H2 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI2D11 (formerly 2D11)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505736) Mouse IgG2a OTI2D11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

Immunohistochemical analysis of paraffin-embedded human cerebra (left) and lung carcinoma (right) tissues, showing nuclear localization with DAB staining using MDM4 antibody Cat.-No AM06258SU-N Mouse IgG1 2D10F4 Ascites Hu E, ICC/IF, P, WB
0.1 ml / €400.00
  Acris Antibodies GmbH

MDM4 antibody

  Rabbit polyclonal MDM4 (Ser367) antibody(Phospho-specific)  
Western blot analysis of extracts from HeLa cells, treated with calyculinA (50ng/ml, 30mins), using MDM4 (Phospho-Ser367) antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI2B8 (formerly 2B8)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505707) Mouse IgG2a OTI2B8 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10)  
Anti-MDM4 mouse monoclonal antibody (TA505712) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MDM4(RC209620). Mouse IgG1 OTI4E10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI3B9 (formerly 3B9)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505724) Mouse IgG2b OTI3B9 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI3A6 (formerly 3A6)  
Immunohistochemical staining of paraffin-embedded Human liver tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505725) Mouse IgG2b OTI3A6 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4G3 (formerly 4G3)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505726) Mouse IgG2b OTI4G3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4D2 (formerly 4D2)  
Immunofluorescent staining of HeLa cells using anti-MDM4 mouse monoclonal antibody (TA505727). Mouse IgG2b OTI4D2 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI1E8 (formerly 1E8)  
Anti-MDM4 mouse monoclonal antibody (TA505732) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MDM4(RC209620). Mouse IgG1 OTI1E8 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI4B10 (formerly 4B10)  
Anti-MDM4 mouse monoclonal antibody (TA505733) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MDM4(RC209620). Mouse IgG1 OTI4B10 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C9 (formerly 2C9)  
Anti-MDM4 mouse monoclonal antibody (TA505734) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MDM4(RC209620). Mouse IgG1 OTI2C9 Purified Hu ICC/IF, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI2E11 (formerly 2E11)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505749) Mouse IgG1 OTI2E11 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 antibody

  MDM4 (MDMX) mouse monoclonal antibody, clone OTI2C1 (formerly 2C1)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human lung tissue using anti-MDM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 120C for 3min, TA505750) Mouse IgG1 OTI2C1 Purified Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

MDM4 pSer367 antibody

Western blot analysis of phosphorylated MdmX (Ser367) expression in MCF7. MCF cells were preincubated with the proteasome inhibitor MG132 (20 µM) and exposed to DNA damaging agent, adriamycin (3 µM) or etoposide (20 µM), for the indicated periods. The cell lysates were used for immunoprecipitation with anti-MdmX antibody (D-19). The immunocomplex was resolved on SDS-PAGE and immunoblotted with anti-MdmX antibody, AM26541AF-S and anti-14-3-3 ß antibody. Mouse IgG2b #15 Azide Free Hu, Ms WB
50 µg / €420.00
  Acris Antibodies GmbH

MDM4 pSer367 antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using MDM4 (Phospho-Ser367) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

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