MDS1 antibody
Principal name
MDS1 antibody
Alternative names for MDS1 antibody
Myelodysplasia syndrome 1, Myelodysplasia syndrome-associated protein 1
Ncbi ID
Available reactivities
Available hosts
Available applications
Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection))
Background of MDS1 antibody
Similar to acetylation and phosphorylation, histone methylation at the N-terminal tail has emerged as an important role in regulating chromatin dynamics and gene activity. Histone methylation occurs on arginine and lysine residues and is catalyzed by two families of proteins, the protein arginine methyltransferase family and the SET-domain-containing methyltransferase family. Five members have been identified in the arginine methyltransferase family. About 27 are grouped into the SET-domain family, and another 17 make up the PR domain family that is related to the SET domain family. MDS1, first identified as part of a fusion transcript resulting from the t(3;21)(q26;q22), encodes a small protein of unknown function. EVI1 encodes a zinc finger protein inappropriately overexpressed by chromosomal rearrangements. EVI1 and MDS1 are unusual in that they can either encode separate proteins, or they can be expressed as a fusion protein MDS1/EVI1. EVI1 and MDS1/EVI1 have opposite functions as transcription factors.
General readings
Gomez-Benito, M., et al. Br. J. Cancer 103(8):1292-1296(2010)
Meyer, T.E., et al. PLoS Genet. 6 (8) (2010)
Goyama, S., et al. Int. J. Hematol. 91(5):753-757(2010)
Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010)
Haas, K., et al. Genes Chromosomes Cancer 47(4):288-298(2008)
Primary Antibodies
| Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
|---|---|---|---|---|---|---|---|
| TA343493 | MDS1 antibody |
||||||
| Rabbit Polyclonal Anti-MDS1 Antibody | |||||||
 |
Rabbit | IgG | Purified | Hu, Ms, Ze | WB |
0.1 mg /
€325.00
|
|
| OriGene Technologies, Inc. | |||||||
| AM11039PU-N | MDS1 (N-term) antibody |
||||||
 |
Mouse | IgG1 | 47AT612.84.88 | Purified | Hu, Ms | WB |
0.4 ml /
€370.00
|
| Acris Antibodies GmbH | |||||||
| AP52645PU-N | MDS1 (Center) antibody |
||||||
 |
Rabbit | Ig | Aff - Purified | Hu, Ms | WB |
0.4 ml /
€370.00
|
|
| Acris Antibodies GmbH | |||||||
CRISPR
| Catalog No. | Species | Donor Vector | |
|---|---|---|---|
| KN309917 | Mecom - mouse gene knockout kit via CRISPR |
||
 |
Mouse | GFP-Puro |
1 kit /
€1,200.00
|
| OriGene Technologies, Inc. | |||
| KN309917BN | Mecom - mouse gene knockout kit via CRISPR |
||
|
Mouse | mBFP-Neo |
1 kit /
€1,290.00
|
| OriGene Technologies, Inc. | |||
Mouse Lenti ORF Particles
| Catalog No. | ||
|---|---|---|
| MR222587L2V | Lenti ORF particles, Mecom (GFP-tagged) - Mouse MDS1 and EVI1 complex locus (Mecom), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€880.00
|
|
| OriGene Technologies, Inc. | ||
| MR222587L1V | Lenti ORF particles, Mecom (Myc-DDK-tagged) - Mouse MDS1 and EVI1 complex locus (Mecom), transcript variant 2, 200 uL, >10^7 TU/mL |
|
|
200 µl /
€780.00
|
|
| OriGene Technologies, Inc. | ||
