MeCP2 antibody
Principal name
MeCP2 antibody
Alternative names for MeCP2 antibody
MeCP-2 protein, Methyl-CpG-binding protein 2
Ncbi ID
9606, 10090, NP_004983, 9541, NP_001104262.1, NP_001104262, NM_010788, NM_001081979, NM_022673, NM_001110792
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ChIP assay (ChIP), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C), Flow Cytometry (F), Dot blot (Dot)
Background of MeCP2 antibody
The epigenetic information encoded as methylated CpG dinucleotides to the transcriptional machinery is transferred by a multifunction methylated DNA binding protein called Methylated CpG biding protein 2. Mutation in MeCP2 protein led to debilitating neurogenerative X-linked autism-spectrum neurodevelopmental disease Rhett syndrome (RTT). Several functional domains have been identified on the MeCP2 protein including Methylated non-methylated DNA binding domains in the first 294 amino acids and a chromatin binding motif near the C-terminal DNA region of the protein (1). The genetic and epigenetic defects led to reduced expression of MeCP2 protein in brain of was autism patients, it may be an important factor in the complex etiology of this disease (2). The gene is located on Xq28 chromosome. Defects in the MeCP2 gene care caused by Angelman syndrome also known as happy puppet syndrome which a neuron-developmental disorder characterized by severe mental retardation, absent of speech, ataxia, sociable affects and dysmorphic facial features similar to Rhett syndrome clinical feature. Rett syndrome (RS) is an X-linked neuron-developmental disorder and the second most common cause of genetic mental retardation in females. Different mutations in MECP2 are found in up to 95% of typical cases of RS. The onset of this disease is caused by non progressive encephalopathy with neonatal onset. The defects in MeCP2 is cause of X-linked mental retardation, Autism 3 (AUTSX3) about 80% of the Rhett syndrome cases have mutational defects in the MeCP2 gene. Expression of this protein sprout generation of neuron and reversal of neurological defects in a moue model of Rett syndrome (3).
MeCP2 protein has 2 AT hook DNA biding domains, a transcriptional repression domain (TRD) and one MBD or Methyl CpG binding domain on the amino terminal end (1-96). Methyl CGp binding protein 2 gene is located on fragile X chromosome and this chromosomal protein binds to methylated DNA. It can bind specifically to a single methyl-CpG pair. The binding is not influenced by sequences flanking the methyl-CpGs. Upon binding it mediates transcriptional repression through interaction with histone deacetylase and co repressor SIN3A. MeCP2, is responsible for transcriptional repression of the leukosialin gene by repression of the Sp1-activated trasnacription. Methyl-CpG-binding protein MeCP2 represses Sp1-activated transcription of the human leukosialin gene when the promoter is methylated (3).
General readings
1. Tatiana Nikitina,1 Xi Shi,2 Rajarshi P. Ghosh,2 Rachel A. Horowitz-Scherer,1 Jeffrey C. Hansen,3 and Christopher L. Woodcock. Multiple Modes of
Interaction between the Methylated DNA Binding Protein MeCP2 and Chromatin. Mol Cell Biol. 2007 November 13.10.1128/MCB.01593-06.
2. Raman P. Nagarajan, Amber R. Hogart, Ynnez Gwye, Michelle R. Martin, and Janine M. LaSalle. Reduced MeCP2 expression is frequent in autism frontal
cortex and correlates with aberrant MECP2 promoter methylation. Epigenetics. 2006 October; 1(4): 172–182.
3. Science 1143-1147, 2007
4. Kudo S. Mol Cell Biol. 1998 Sep;18(9):5492-9




































- Quick-Filters:
- Highly Validated (1)
Primary Antibodies
Catalog No. | Host | Iso. | Clone | Pres. | React. | Applications | |
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AM31107PU-N | MeCP2 (81-170) antibody |
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Mouse | IgG2a | 4B6 | Purified | Hu, Ms, Rt | E, P, WB |
50 µg /
€420.00
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Acris Antibodies GmbH | |||||||
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Highly validated antibody! |
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TA309165 | MeCP2 antibody |
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Rabbit Anti-MeCP2 (Ser80) Antibody (Phospho-Specific) | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt | WB |
0.1 ml /
€338.00
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OriGene Technologies, Inc. | |||||||
TA331114 | MeCP2 antibody |
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Rabbit Polyclonal Anti-MECP2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ye | WB |
50 µg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA332083 | MeCP2 antibody |
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Rabbit Polyclonal Anti-MECP2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, Hu, Ms, Por, Rt | WB |
0.1 mg /
€360.00
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OriGene Technologies, Inc. | |||||||
TA332847 | MeCP2 antibody |
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Rabbit anti-MECP2 Polyclonal Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms, Rt |
0.1 mg /
€335.00
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OriGene Technologies, Inc. | |||||||
TA343494 | MeCP2 antibody |
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Rabbit Polyclonal Anti-MECP2 Antibody | |||||||
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Rabbit | IgG | Purified | Bov, Can, Eq, GP, Hu, Ms, Rb, Rt, Ze | WB |
50 µg /
€360.00
|
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OriGene Technologies, Inc. | |||||||
TA347243 | MeCP2 antibody |
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Rabbit Polyclonal MeCP2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E |
50 µg /
€392.00
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OriGene Technologies, Inc. | |||||||
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TA347244 | MeCP2 antibody |
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Rabbit Polyclonal MeCP2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu, Ms |
50 µg /
€392.00
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OriGene Technologies, Inc. | |||||||
TA347245 | MeCP2 antibody |
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Rabbit Polyclonal MeCP2 Antibody | |||||||
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Rabbit | IgG | Purified | Hu | E |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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TA347246 | MeCP2 antibody |
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Rabbit Polyclonal MeCP2 Antibody | |||||||
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Rabbit | IgG | Purified | Ms | E |
0.1 ml /
€335.00
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OriGene Technologies, Inc. | |||||||
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73-273 | MeCP2 antibody |
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Mouse | IgG1 | N227/21 | Supernatant | Hu, Ms, Rt | C, Dot |
5 ml /
€460.00
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Antibodies Incorporated | |||||||
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75-273 | MeCP2 antibody |
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Mouse | IgG1 | N227/21 | Purified | Hu, Ms, Rt | C, Dot |
0.1 ml /
€540.00
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Antibodies Incorporated | |||||||
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AP08458PU-N | MeCP2 (1-25, 181-195) antibody |
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Rabbit | IgG | Aff - Purified | Hu | P, WB |
50 µg /
€380.00
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Acris Antibodies GmbH | |||||||
AP12280PU-N | MeCP2 antibody |
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Rabbit | Ig | Aff - Purified | Hu, Ms | WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
AP13005PU-N | MeCP2 pSer80 antibody |
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Rabbit | Ig | Aff - Purified | Hu |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
AP52648PU-N | MeCP2 (N-term) antibody |
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Rabbit | Ig | Aff - Purified | Hu | F, P, WB |
0.4 ml /
€370.00
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Acris Antibodies GmbH | |||||||
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CRISPR
Catalog No. | Species | Donor Vector | |
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KN202382 | MECP2 - human gene knockout kit via CRISPR |
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Human | GFP-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN202382BN | MECP2 - human gene knockout kit via CRISPR |
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Human | mBFP-Neo |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN202382LP | MECP2 - human gene knockout kit via CRISPR |
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Human | Luciferase-Puro |
1 kit /
€1,290.00
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OriGene Technologies, Inc. | |||
KN202382RB | MECP2 - human gene knockout kit via CRISPR |
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Human | RFP-BSD |
1 kit /
€1,290.00
|
OriGene Technologies, Inc. |