MED28 antibody

Principal name

MED28 antibody

Alternative names for MED28 antibody

EG1, FKSG20, Mediator complex subunit 28, Mediator of RNA polymerase II transcription subunit 28, Tumor angiogenesis marker EG-1, Endothelial-derived protein 1, Merlin and Grb2-interacting cytoskeletal protein

SwissProt ID

P68943 (Rat), Q2TBN4 (Bovin), Q920D3 (Mouse), Q9H204 (Human)

Gene ID

80306 (MED28)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat)

Available hosts

Rabbit

Available applications

Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of MED28 antibody

The mediator complex is a multi-protein transcriptional co-activator that is expressed ubiquitously in eukaryotes from yeast to mammals and is required for induction of RNA polymerase II (pol II) transcription by DNA binding transcription factor. One of the proteins in this complex is MED28, also known as Magicin. MED28 is expressed in many cell lines and tissues. It has been shown that a down-regulation of MED28 expression in NIH3T3 cells results in a significant induction of several genes associated with smooth muscle cell differentiation and conversely its over-expression represses expression of SMC genes. MED28 can also form a ternary complex with Grb2 and Merlin, the neurofibromatosis 2 tumor suppressor protein, indicating that MED28 may play a role in Merlin's tumor suppressive activity. MED28 has also been recently identified as an HIV dependency factor (HDF), suggesting that MED28 may be an important drug target in HIV treatment. At least two isoforms of MED28 are known to exist.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MED28 antibody

Western blot analysis of MED28 in human brain tissue lysate with MED28 antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide. Rabbit IgG Aff - Purified Hu, Ms E, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MED28 antibody

Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) Rabbit Purified Hu, Ms P, WB
50 µg / €470.00
  Acris Antibodies GmbH

MED28 Control Peptide

MED28
50 µg / €160.00
  Acris Antibodies GmbH

MED28 antibody

Western blot analysis of MED28 in human brain tissue lysate with MED28 polyclonal antibody ( Cat # PAB13054 ) at 1 µg/ml in ( A ) the absence and ( B ) the presence of blocking peptide. Rabbit Hu, Ms WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MED28 antibody

MED28 Rabbit Aff - Purified Hu, Ms P, WB
50 µg / €480.00
  Novus Biologicals Inc.

MED28 antibody

Immunohistochemistry-Paraffin: MED28 Antibody [NBP1-76931] - Human brain tissue with MED28 antibody at 2.5 ug/mL._x000d_ Rabbit Aff - Purified Hu, Ms E, P, WB
0.1 mg / €440.00
  Novus Biologicals Inc.

MED28 antibody

Immunohistochemistry-Paraffin: MED28 Antibody [NBP1-85104] - Immunohistochemical staining of human hippocampus shows moderate cytoplasmic and nuclear membranous positivity in neurons. Rabbit IgG Aff - Purified Hu ICC/IF, P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

MED28 (full length, N-term HIS tag)

MED28 Human > 80 %
Preparation: .
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
50 µg / €199.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

MED28 overexpression lysate

MED28 overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

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