Melanoma gp100 antibody

Principal name

Melanoma gp100 antibody

Alternative names for Melanoma gp100 antibody

SILV, D12S53E, PMEL17, ME20-M, Melanocyte protein Pmel 17, Silver locus protein homolog, Melanocyte lineage-specific antigen GP100, Melanoma-associated ME20 antigen

SwissProt ID

P40967 (Human), Q06154 (Bovin), Q60696 (Mouse), Q98917 (Chick)

Gene ID

6490 (PMEL)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Mky (Monkey), Eq (Equine), GP (Guinea Pig), Gt (Goat), Rb (Rabbit)

Available hosts

Goat, Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Flow Cytometry (F), Frozen Sections (C)

Background of Melanoma gp100 antibody

The mammalian members of the MAGE (melanoma-associated antigen) gene family were originally described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. By contrast, these genes were expressed in various kinds of tumors.
MAGE-like genes have also been identified in non-mammalian species, like the zebrafish or Drosophila melanogaster. Although no MAGE homologous sequences have been identified in Caenorhabditis elegans, Saccharomyces cerevisiae or Schizosaccharomyces pombe, MAGE sequences have been found in several vegetal species, including Arabidopsis thaliana.
The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. It has been proposed that the MAGE conserved domain of MAGE-D proteins might interact with p75 neurotrophin or related receptors.
The function of this protein is not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
The Melanoma-associated antigen is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, leukemias and lymphomas.

General readings

Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. PLoS Biol. 2006 Jan;4(1):e6. PMID: 16300414

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Melanoma gp100 antibody

Immunohistochemical staining of paraffin-embedded breast tissue within the normal limits using anti-SILV  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500424, Dilution 1:50) Mouse IgG2b OTI10E5 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SILV mouse monoclonal antibody. (TA500425) Mouse IgG2b OTI7E3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma tissue stained with gp100 Antibody Cat.-No AM33121PU (Clone NKI-beteb) using peroxidase-conjugate and DAB chromogen. Mouse IgG2b NKI/beteb Purified Eq, Hu C, F, ICC/IF, IP, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma tissue stained with gp100 Antibody Cat.-No AM33121PU (Clone NKI-beteb) using peroxidase-conjugate and DAB chromogen. Mouse IgG2b NKI/beteb Purified Eq, Hu C, F, ICC/IF, IP, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma tissue stained with gp100 Antibody Cat.-No AM33121PU (Clone NKI-beteb) using peroxidase-conjugate and DAB chromogen. Mouse IgG2b NKI/beteb Purified Eq, Hu C, F, ICC/IF, IP, P
20 µg / €160.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-SILV mouse monoclonal antibody. (TA500400) Mouse IgG1 OTI9G3 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-SILV mouse monoclonal antibody. (TA500402) Mouse IgG2b OTI8A4 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

Immunohistochemistry-Paraffin: Melanoma gp100 Antibody (10E5) [NBP1-47974] - Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-SILV mouse monoclonal antibody. (Dilution 1:50) Mouse 10E5 Aff - Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €530.00
  Novus Biologicals Inc.

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with Melanoma gp100 Antibody Cat.-No AM33241SU (Clone HMB45). Mouse IgG1 HMB45 Supernatant Hu C, F, ICC/IF, IP, P, WB
1.0 ml / €360.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with Melanoma gp100 Antibody Cat.-No AM33241SU (Clone HMB45). Mouse IgG1 HMB45 Supernatant Hu C, F, ICC/IF, IP, P, WB
0.5 ml / €290.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with Melanoma gp100 Antibody Cat.-No AM33241SU (Clone HMB45). Mouse IgG1 HMB45 Supernatant Hu C, F, ICC/IF, IP, P, WB
0.1 ml / €150.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €390.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €160.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Paraffin Human melanoma tissue stained with gp100 Antibody Cat.-No AM50169PU (Clone SPM286). Mouse IgG2b SPM286 Purified Hu C, F, ICC/IF, P
0.2 mg / €390.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Paraffin Human melanoma tissue stained with gp100 Antibody Cat.-No AM50169PU (Clone SPM286). Mouse IgG2b SPM286 Purified Hu C, F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

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