Melanoma gp100 antibody

Principal name

Melanoma gp100 antibody

Alternative names for Melanoma gp100 antibody

SILV, D12S53E, PMEL17, ME20-M, Melanocyte protein Pmel 17, Silver locus protein homolog, Melanocyte lineage-specific antigen GP100, Melanoma-associated ME20 antigen

SwissProt ID

P40967 (Human), Q06154 (Bovin), Q60696 (Mouse), Q98917 (Chick)

Gene ID

6490 (PMEL)

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat), Eq (Equine), Mky (Monkey), GP (Guinea Pig), Gt (Goat), Rb (Rabbit)

Available hosts

Rabbit, Goat, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Frozen Sections (C)

Background of Melanoma gp100 antibody

The mammalian members of the MAGE (melanoma-associated antigen) gene family were originally described as completely silent in normal adult tissues, with the exception of male germ cells and, for some of them, placenta. By contrast, these genes were expressed in various kinds of tumors.
MAGE-like genes have also been identified in non-mammalian species, like the zebrafish or Drosophila melanogaster. Although no MAGE homologous sequences have been identified in Caenorhabditis elegans, Saccharomyces cerevisiae or Schizosaccharomyces pombe, MAGE sequences have been found in several vegetal species, including Arabidopsis thaliana.
The only region of homology shared by all of the members of the family is a stretch of about 200 amino acids which has been named the MAGE conserved domain. The MAGE conserved domain is usually located close to the C-terminal, although it can also be found in a more central position in some proteins. The MAGE conserved domain is generally present as a single copy but it is duplicated in some proteins. It has been proposed that the MAGE conserved domain of MAGE-D proteins might interact with p75 neurotrophin or related receptors.
The function of this protein is not known, though may play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
The Melanoma-associated antigen is expressed in many tumors of several types, such as melanoma, head and neck squamous cell carcinoma, lung carcinoma and breast carcinoma, but not in normal tissues except for testes and placenta. Never expressed in kidney tumors, leukemias and lymphomas.

General readings

Theos,A.C., (2006) Dev. Cell 10 (3), 343-354

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Melanoma gp100 antibody

  anti-SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI10E5 (formerly 10E5)  
Immunohistochemical staining of paraffin-embedded breast tissue within the normal limits using anti-SILV  mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500424, Dilution 1:50) Mouse IgG2b OTI10E5 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

  SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI7E3 (formerly 7E3)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-SILV mouse monoclonal antibody. (TA500425) Mouse IgG2b OTI7E3 Purified Hu F, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

  anti-SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI9G3 (formerly 9G3)  
Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-SILV mouse monoclonal antibody. (TA500400) Mouse IgG1 OTI9G3 Purified Can, Hu ICC/IF, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

  anti-SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI8A4 (formerly 8A4)  
Immunohistochemical staining of paraffin-embedded Human prostate tissue within the normal limits using anti-SILV mouse monoclonal antibody. (TA500402) Mouse IgG2b OTI8A4 Purified Can, Hu, Mky, Rt ICC/IF, P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.1 ml / €280.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.2 ml / €370.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
0.5 ml / €460.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 (C-term) antibody

Formalin-Fixed, Paraffin-Embedded Human melanoma skin cancer tissue (4 µm) stained with anti-Melanosome antibody (DB 049) shows specific positive immunostaining. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit IgG P14-V Aff - Purified Hu P
1 ml / €720.00
  DB Biotech, spol. s r.o.

Sample sizes available

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
0.2 mg / €410.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
0.1 mg / €320.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Fixed, Paraffin-Embedded Human Melanoma (20X) stained with gp100 / Melanosome Antibody Cat.-No AM50168PU (Clone SPM142). Mouse IgG1 SPM142 Purified Hu C, F, ICC/IF, IP, P, WB
20 µg / €180.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Paraffin Human melanoma tissue stained with gp100 Antibody Cat.-No AM50169PU (Clone SPM286). Mouse IgG2b SPM286 Purified Hu C, F, ICC/IF, P
0.2 mg / €410.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Paraffin Human melanoma tissue stained with gp100 Antibody Cat.-No AM50169PU (Clone SPM286). Mouse IgG2b SPM286 Purified Hu C, F, ICC/IF, P
0.1 mg / €320.00
  Acris Antibodies GmbH

Melanoma gp100 antibody

Formalin-Paraffin Human melanoma tissue stained with gp100 Antibody Cat.-No AM50169PU (Clone SPM286). Mouse IgG2b SPM286 Purified Hu C, F, ICC/IF, P
20 µg / €180.00
  Acris Antibodies GmbH

Melanoma gp100 (C-term) antibody

  Goat Polyclonal Antibody against Silver homologue / Pmel 17  
TA302608 (1 ug/ml) staining of Human Skin lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Melanoma gp100 antibody

  Rabbit Polyclonal Anti-SILV Antibody  
WB Suggested Anti-SILV Antibody Titration: 1.25 ug/ml; Positive Control: HepG2 cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Gt, Hu, Ms, Por, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Melanoma gp100 antibody

  Rabbit Polyclonal anti-Melanoma (gp100) Antibody  
Human Melanoma stained with anti-Melanoma (gp100) antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Melanoma gp100 antibody

  anti-SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI7B2 (formerly 7B2)  
Immunofluorescent staining of HT29 cells using anti-SILV mouse monoclonal antibody (TA500423). Mouse IgG1 OTI7B2 Purified Hu F, ICC/IF
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

  SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI1E5 (formerly 1E5)  
Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-SILV mouse monoclonal antibody. (TA803054) Dilution: 1:150 Mouse IgG1 OTI1E5 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melanoma gp100 antibody

  SILV (Melanoma gp100) mouse monoclonal antibody, clone OTI6D5 (formerly 6D5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SILV (RC200663, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SILV. Mouse IgG1 OTI6D5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

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