Melastatin-4 antibody

Principal name

Melastatin-4 antibody

Alternative names for Melastatin-4 antibody

TRPM4, LTRPC4, Long transient receptor potential channel 4, Melastatin-4, Transient receptor potential cation channel subfamily M member 4, Calcium-activated non-selective cation channel 1

SwissProt ID

Q7TN37 (Mouse), Q8TD43 (Human), Q9ESQ5 (Rat)

Gene ID

171143 (Trpm4), 54795 (TRPM4), 68667

Available reactivities

Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Hu (Human), Mky (Monkey), Eq (Equine), GP (Guinea Pig)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Enzyme Immunoassay (E), Flow Cytometry (F)

Background of Melastatin-4 antibody

Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. While it is activated by increase in intracellular Ca(2+), it is impermeable to it. Mediates transport of monovalent cations (Na(+) > K(+) > Cs(+) > Li(+)), leading to depolarize the membrane. It thereby plays a central role in cadiomyocytes, neurons from entorhinal cortex, dorsal root and vomeronasal neurons, endocrine pancreas cells, kidney epithelial cells, cochlea hair cells etc. Participates in T-cell activation by modulating Ca(2+) oscillations after T lymphocyte activation, which is required for NFAT-dependent IL2 production. Involved in myogenic constriction of cerebral arteries. Controls insulin secretion in pancreatic beta-cells. May also be involved in pacemaking or could cause irregular electrical activity under conditions of Ca(2+) overload. Affects T-helper 1 (Th1) and T-helper 2 (Th2) cell motility and cytokine production through differential regulation of calcium signaling and NFATC1 localization. Enhances cell proliferation through up-regulation of the beta-catenin signaling pathway.Involvement in disease:Defects in TRPM4 are the cause of progressive familial heart block type 1B (PFHB1B) [MIM:604559]. It is a cardiac bundle branch disorder characterized by progressive alteration of cardiac conduction through the His-Purkinje system, with a pattern of a right bundle-branch block and/or left anterior hemiblock occurring individually or together. It leads to complete atrio-ventricular block causing syncope and sudden death.

  1. Quick-Filters:
  2. Cited (1)
  3. Highly Validated (5)

17 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Melastatin-4 antibody

Immunohistochemical staining of paraffin-embedded Human Ovary tissue within the normal limits using anti-TRPM4 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500381) Mouse IgG1 OTI10H5 Purified Can, Hu, Mky P, WB
0.1 ml / €379.00
  OriGene Technologies, Inc.

TrueMAB

Melastatin-4 antibody

WB Suggested Anti-TRPM4 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 293T cell lysate Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

Melastatin-4 antibody

Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-TRPM4mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500368, Dilution 1:50) Mouse IgG1 OTI14C3 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melastatin-4 antibody

Human Hela; Host: Rabbit. Target Name: TRPM4. Sample Tissue: Hela. Antibody Dilution: 1.0ug/ml.; TRPM4 antibody - N-terminal region (ARP35268_P050) in Human Hela cells using Western Blot Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €350.00
  AVIVA Systems Biology

Melastatin-4 antibody

Immunohistochemistry-Paraffin: TRPM4 Antibody (10H5) [NBP1-48036] - Immunohistochemical staining of paraffin-embedded Ovary tissue using anti-TRPM4mouse monoclonal antibody. (Dilution 1:50) Mouse 10H5 Aff - Purified Hu P, WB
0.1 ml / €620.00
  Novus Biologicals Inc.

Melastatin-4 antibody

Western blot analysis of rat lung (lanes 1 and 5), rat heart membrane (lanes 2 and 6), mouse brain membrane (lanes 3 and 7) and ms1 cells lysate (lanes 4 and 8): 1-4. Anti-TRPM4 antibody, (1:200). 5-8. Anti-TRPM4 antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

Melastatin-4 antibody

Anti-TRPM4 antibody IHC of human pancreas, islet. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky
50 µg / €379.00
  OriGene Technologies, Inc.

Melastatin-4 antibody

Anti-TRPM4 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

Melastatin-4 antibody

Anti-TRPM4 antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu, Mky, Ms
50 µg / €379.00
  OriGene Technologies, Inc.

Melastatin-4 antibody

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TRPM4 (RC216888, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-TRPM4. Mouse IgG1 OTI3C4 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melastatin-4 antibody

Immunohistochemical staining of paraffin-embedded pancreas tissue within the normal limits using anti-TRPM4mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500377, Dilution 1:50) Mouse IgG1 OTI14F1 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Melastatin-4 (C-term) antibody

TRPM4 Antibody (C-term) (AP54363PU-N) western blot analysis in 293 cell line lysates (35 µg/lane). This demonstrates the TRPM4 antibody detected the TRPM4 protein (arrow). Rabbit Ig Aff - Purified Hu WB
0.4 ml / €370.00
  Acris Antibodies GmbH

Melastatin-4 antibody

Melastatin-4 Rabbit Serum Ms C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

Melastatin-4 antibody

Melastatin-4 Rabbit Serum Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Melastatin-4 antibody

Melastatin-4 Goat Purified Ms, Rt P, WB
0.1 ml / €400.00
  Novus Biologicals Inc.

Proteins & Growth Factors

Catalog No. Species Pres. Purity Source  

Melastatin-4

Melastatin-4 Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €680.00
  OriGene Technologies, Inc.

Lysates

Catalog No.    

TRPM4 overexpression lysate

TRPM4 overexpression lysate  
0.1 mg / €480.00
  OriGene Technologies, Inc.

17 Item(s)

per page
  • LinkedIn