Melatonin Receptor 1B antibody

Principal name

Melatonin Receptor 1B antibody

Alternative names for Melatonin Receptor 1B antibody

MTNR1B, Melatonin receptor type 1B

SwissProt ID

P49286 (Human), P49287 (Rat), P51050 (Chick), Q8CIQ6 (Mouse)

Gene ID

4544 (MTNR1B), 244701

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Mky (Monkey)

Available hosts

Rabbit, Goat

Available applications

Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E)

Background of Melatonin Receptor 1B antibody

Melatonin (N-acetyl-5-methoxytryptamine) is a product of tryptophan metabolism. It is synthesized in the pineal gland and is secreted to control the circadian rhythm. Melatonin is also synthesized in the gastrointestil tract, reti, skin and other tissues where it acts in a autocrine or paracrine manner. The role of melatonin in these tissues is independent of its role in the circadian rhythm, where it plays a role in energy metabolism, physiological growth, differentiation and responsiveness in stress stimuli. The pleiotropic effects of melatonin have given rise to various therapeutic possibilities for this molecule. For example; anti-stress, sexual dysfunction, obesity, gallbladder stones. To date, the only therapeutic uses for melatonin remain to treat sleep disorders, depression, migraine and headaches. Melatonin exerts its effects through two G-protein coupled receptors (GPCRs); melatonin receptor type 1 and melatonin receptor type 2 (MT1 and MT2). Like all GPCRs, they have seven transmembrane domains and extracellular N-termil and cytoplasmic C-termil tails. The binding of melatonin to either receptor activates Gi, thereby activating PLC, thus increasing intracellular Ca2+ levels. Both receptors structurally bind melatonin in the same manner, although MT2 displays a much higher affinity for the hormone. Just like melatonin levels are detected in many tissues, the expression patterns of the two receptors are also quite broad. For example, MT1 is detected in the brain, reti and kidneys and MT2 is expressed in brain and in the reti. MT1 is involved in sleep regulation and might also have effects on peripheral vasoconstriction. MT2 may play an important physiological role in the reti and might regulate body temperature.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Melatonin Receptor 1B antibody

Western blot (WB) analysis of MEL-1B-R antibody (Cat.-No.: AP01322PU-N) in extracts from 293/Jurkat/HepG2 cells. Rabbit Aff - Purified Hu WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Melatonin Receptor 1B antibody

Western blot analysis of mouse (lanes 1 and 3) and rat (lanes 2 and 4) brain lysates: 1,2. Anti-Melatonin Receptor Type 2 antibody, (1:200). 3,4. Anti-Melatonin Receptor Type 2 antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
50 µl / €325.00
  OriGene Technologies, Inc.

Melatonin Receptor 1B (Cytopl. Dom.) antibody

Anti-MTNR1B antibody IHC of human brain. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu P
50 µg / €379.00
  OriGene Technologies, Inc.

Melatonin Receptor 1B (Extracell. Dom.) antibody

Anti-MTNR1B / MT2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

Melatonin Receptor 1B antibody

Western blot analysis of extracts from 293 cells, Jurkat cells and HepG2 cells, using MTR1B antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Melatonin Receptor 1B (N-Term, Extracel. Dom.) antibody

Eye, retina: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Gorilla, Hu E, P
50 µg / €470.00
  Acris Antibodies GmbH

Melatonin Receptor 1B (C-term, Cytopl. Dom.) antibody

Brain, hippocampus: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Gorilla, Hu, Mky E, P
50 µg / €470.00
  Acris Antibodies GmbH

Melatonin Receptor 1B antibody


MTNR1B antibody Cat.-No AP31974PU-N staining of paraffin embedded Human Cerebellum at 3.8 µg/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.
Goat Aff - Purified Hu E, P
0.1 mg / €340.00
  Acris Antibodies GmbH

Melatonin Receptor 1B Control Peptide

Melatonin Receptor 1B Purified
50 µg / €220.00
  Acris Antibodies GmbH

Melatonin Receptor 1B antibody

Western blot analysis of extracts from 293/Jurkat/HepG2 cells, using MTR1B Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
50 µg / €205.00
  Assay Biotech

Melatonin Receptor 1B antibody

Western blot analysis of extracts from 293/Jurkat/HepG2 cells, using MTR1B Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, WB
0.1 mg / €310.00
  Assay Biotech

Melatonin Receptor 1B antibody

Western Blot: MEL-1B-R Antibody [NBP1-00922] - Western blot (WB) analysis of MEL-1B-R (V39) antibody in extracts from 293/Jurkat/HepG2 cells. Rabbit Aff - Purified Hu WB
0.1 mg / €420.00
  Novus Biologicals Inc.

Melatonin Receptor 1B antibody

Melatonin Receptor 1B Goat IgG Hu E, P, WB
0.1 mg / €400.00
  Novus Biologicals Inc.

Melatonin Receptor 1B antibody

Immunohistochemistry-Paraffin: Melatonin Receptor 1B Antibody [NBP1-84983] - Immunohistochemical staining of human duodenum shows moderate cytoplasmic positivity in glandular cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Melatonin Receptor 1B antibody

Immunohistochemistry-Paraffin: Melatonin Receptor 1B Antibody [NBP1-84984] - Immunohistochemical staining of human adrenal gland shows strong cytoplasmic positivity in cortical cells. Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €500.00
  Novus Biologicals Inc.

Melatonin Receptor 1B antibody

Western Blot: Melatonin Receptor 1B Antibody [NLS932] - WB analysis of Melatonin Receptor 1B in: 1. HepG2 and 2. A431 Rabbit Aff - Purified Hu, Ms P, WB
50 µl / €380.00
  Novus Biologicals Inc.

Melatonin Receptor 1B antibody

Melatonin Receptor 1B Rabbit Aff - Purified Hu, Ms P, WB
25 µl / €230.00
  Novus Biologicals Inc.

Lysates

Catalog No.    

MTNR1B overexpression lysate

MTNR1B overexpression lysate  
0.1 mg / €280.00
  OriGene Technologies, Inc.

18 Item(s)

per page
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