Merlin antibody

Principal name

Merlin antibody

Alternative names for Merlin antibody

Neurofibromin-2, NF2, SCH, Schwannomin, Schwannomerlin, Moesin-ezrin-radixin-like protein, Schwannomin, Schwannomerlin

SwissProt ID

P35240 (Human), P46662 (Mouse), P59750 (Papan), Q63648 (Rat)

Gene ID

4771 (NF2), 18016 (Nf2), 25744

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Chk (Chicken), Can (Canine), Mky (Monkey)

Available hosts

Rabbit, Goat, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of Merlin antibody

Neurofibromatosis type 2 (NF2) is a dominantly inherited disorder characterized by the occurance of bilateral vestibular schwannomas and other central nervous system tumors, including multiple meningiomas. NF2 occurs in about 1 of 40,000 live births. The NF2 gene is highly penetrant; NF2-affected individuals have a 95% chance of developing bilateral vestibular schwannomas. NF2 is distinct from NF1, which is characterized by an incidence of 1 in 4000, maps to chromosome 17 and encodes a protein designated neurofibromin, which is a large protein with a GAP domain. Genetic linkage studies of both sporadic and familial tumors suggest that NF2 is caused by inactivation of a tumor suppressor gene that maps on chromosome 22q12 and encodes a 595 amino acid protein whose function appears to be mediated by interaction with the cytoskeleton.

General readings

Gutmann DH, Wright DE, Geist RT, Snider WD (1995) Expression of the neurofibromatosis 2 (NF2) gene isoforms during rat embryonic development. Human Molecular Genetics 4:471-478.
Scherer SS, Gutmann DH (1997) Expression of the neurofibromatosis 2 tumor suppressor gene product, merlin, in Schwann cells. J. Neurosci. Res. 46:595-605.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Merlin antibody

  Rabbit Polyclonal Merlin Antibody  
Immunofluorescent staining of HeLa cells using anti-NF2 rabbit polyclonal antibody (TA590014). Rabbit IgG Purified Can, Hu, Mky, Ms, Rt E, ICC/IF, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Merlin antibody

  Rabbit anti-NF2 (Merlin, Phospho-Ser518) polyclonal antibody(Phospho-specific)  
Western blot analysis of extracts from HUVEC cells untreated or treated with IFN-a (100ng/ml, 15min) using Merlin antibody (Lanes 1 and 2) and Merlin (phospho-Ser518) antibody (Lanes 3 and 4). Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Merlin pSer518 antibody

  Rabbit polyclonal NF2 phospho S518 antibody  
Phospho-specific antibody to NF2 (Merlin) at pS518 was used at a 1:1000 dilution to detect NF2 by WB. Approximately 12 ul of a mouse cardiac myocyte lysate was loaded per lane on a 4-20% Criterion gel for SDS-PAGE. Samples were either mock treated (lane 1) or CLA treated at 4nM, 20 nM or 100 nM (lanes 2, 3 and 4 respectively) for 45'. After washing, a 1:5,000 dilution of HRP conjugated Gt-a-Rabbit IgG  preceded color development using Amersham's substrate system. Rabbit Aff - Purified Hu, Ms E, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

Merlin (N-term) antibody

  Rabbit polyclonal Merlin Antibody (N-term)  
Western blot analysis of Merlin Antibody (N-term) (Cat. #TA324866) in NCI-H460 cell line lysates (35ug/lane). NF2 (arrow) was detected using the purified Pab. Rabbit Hu ICC/IF, P, WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

Merlin antibody

  Rabbit Polyclonal Merlin Antibody  
Western blot analysis of Merlin phosphorylation expression in IFN-a treated HuvEc whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Merlin antibody

  Rabbit Polyclonal Merlin (Ser518) Antibody (Phospho-specific)  
Western blot analysis of Merlin phosphorylation expression in IFN-a treated HuvEc whole cell lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Merlin antibody

  Phospho-NF2-S518 Rabbit Polyclonal Antibody  
Merlin Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

Merlin pSer518 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using Merlin pSer518 antibody AP02513PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Merlin pSer518 antibody

Figure 2. Immunofluorescence staining of methanol-fixed HeLa cells using Merlin pSer518 antibody AP02513PU (Red). Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
50 µl / €240.00
  Acris Antibodies GmbH

Merlin antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Merlin antibody Cat.-No AP02759PU-N/PU-S. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 ml / €320.00
  Acris Antibodies GmbH

Merlin antibody

Figure 1. Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue, using Merlin antibody Cat.-No AP02759PU-N/PU-S. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µl / €240.00
  Acris Antibodies GmbH

Merlin pSer518 antibody

AP07606PU-N NF2 antibody staining of Formalin-Fixed Paraffin-Embedded Human Brain, cortex at 2.5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu, Ms E, IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

Merlin antibody

AP08595PU-N at 5µg/ml staining NF2/Merlin in Zebrafish brain cortex by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Goat IgG Aff - Purified Hu, Ze E, P
50 µg / €470.00
  Acris Antibodies GmbH

Merlin antibody

Merlin Goat Aff - Purified Ze E, P
0.1 mg / €350.00
  Acris Antibodies GmbH

Merlin antibody

Western blot (WB) analyzes of Merlin antibody (Cat.-No.: AP20757PU-N) in extracts from HuvEc cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Merlin pSer518 antibody

Western blot (WB) analyzes of p-NF2 antibody (Cat.-No.: AP20869PU-N) in extracts from Jurkat IFN cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

Merlin pSer518 antibody

Western blot analysis of extracts from HuvEc cells treated with IFN-alpha 1000U/ml 18h, using Merlin (Phospho-Ser518) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €230.00
  Assay Biotech

Merlin pSer518 antibody

Western blot analysis of extracts from HuvEc cells treated with IFN-alpha 1000U/ml 18h, using Merlin (Phospho-Ser518) Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €330.00
  Assay Biotech

Merlin pSer10 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Merlin (Phospho-Ser10) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

Merlin pSer10 antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using Merlin (Phospho-Ser10) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

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