MERTK antibody

Principal name

MERTK antibody

Alternative names for MERTK antibody

C-mer, MER, Receptor tyrosine kinase MerTK, Proto-oncogene tyrosine-protein kinase MER

SwissProt ID

P57097 (Rat), Q12866 (Human), Q60805 (Mouse)

Gene ID

10461 (MERTK), 17289 (Mertk)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey), Prim (Primate)

Available hosts

Rabbit, Goat, Mouse, Rat

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Frozen Sections (C), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of MERTK antibody

In vertebrate, the photoreceptor cells are the basic sensory apparatus of the retina primarily converting photon energy absorbed from light into neuronal signals. The photoreceptor proximal outer segments are synthesized daily by cell bodies, and outer segment tips are removed with a circadian rhythm. The shed outer segments are endocytosed by adjacent retinal pigment epithelial (RPE) cells, and are recycled to photoreceptors (1). Mutation of a receptor tyrosine kinase gene, Mertk, in the Royal College of Surgeons (RCS) rat results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration (2) resulting in to retinitis pigmentosa.
The receptor tyrosine kinase MERTK protein is a approximately 170-175 kDa (994 amino acids) protein expressed in long evans rat testis and RPEs. The MERTK protein has a tyrosine kinase domain closer to the C-terminal region and putative phosphorylation sites.

General readings

General / background references:Gal A et al. Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. Nat Genet 26:270-1 (2000). PubMed PMID: 11062461
D'Cruz PM et al. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat. Hum Mol Genet 9:645-51 (2000). PubMed PMID: 10699188

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

MERTK antibody

Western blot analysis of extracts from K562 cells and Jurkat cells, using MERTK antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Western blot analysis of extracts from NIH-3T3 cells, using MER/TYRO3 (Ab-753/685)antibody.The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using MERTK antibody at dilution 1/13, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Predicted cell location: Cytoplasm. Positive control: Human cervical cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using MERTK antibody at dilution 1/13, on the right is treated with the fusion protein. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

MERTK antibody

MER Antibody (Cat. #TA324995) western blot analysis in Jurkat cell line lysates (35ug/lane).This demonstrates the MER antibody detected the MER protein (arrow). Rabbit Ig Purified Hu WB
0.4 ml / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Anti-MERTK antibody (2µg/ml) staining of Daudi lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Western blot analysis of extracts of various cell lines, using MERTK antibody. Rabbit IgG Purified Hu, Ms
0.1 mg / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Western Blot: MERTK Antibody [TA337021] - analysis of MERTK in human spleen lysate in the 1) absence 2) presence of immunizing peptide and 3) mouse spleen lysate using this antibody. 0 ug/ml, 2.0 ug/ml and 0.5 ug/ml respectively. Rabbit Purified Hu, Ms, Prim WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

MERTK antibody

Western blot analysis using MER antibody Cat.-No AM06188SU-N against full-length MER recombinant protein. Mouse IgG1 7E5G1 Ascites Hu WB
0.1 ml / €360.00
  Acris Antibodies GmbH

MERTK Control Peptide

MERTK
0.25 mg / €250.00
  Acris Antibodies GmbH

MERTK (N-term) antibody

MERTK Rabbit Aff - Purified Hu, Mky, Ms, Rt C, IP, WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MERTK Control Peptide

MERTK
0.25 mg / €250.00
  Acris Antibodies GmbH

MERTK antibody

MERTK Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.1 mg / €420.00
  Acris Antibodies GmbH

MERTK control peptide

MERTK
0.1 mg / €250.00
  Acris Antibodies GmbH

MERTK (C-term) antibody

MERTK Rabbit Aff - Purified Hu, Ms, Rt C, IP, WB
0.25 mg / €420.00
  Acris Antibodies GmbH

MERTK (N-term) antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with MERK antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. Rabbit Ig Purified Hu, Ms WB
0.4 ml / €370.00
  Acris Antibodies GmbH

MERTK antibody

MERTK Mouse IgG1 2D2 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

MERTK antibody

Formalin-fixed and paraffin-embedded human brain tissue reacted with MERTK polyclonal antibody ( Cat # PAB3367 ) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry ; clinical relevance has not been evaluated. Rabbit Hu, Ms E, P, WB
0.1 mg / €390.00
  Abnova Taiwan Corp.

MERTK antibody

MERTK Goat Hu E
0.1 mg / €390.00
  Abnova Taiwan Corp.

MERTK pTyr749/681 antibody

Immunohistochemistry analysis of paraffin-embedded human brain, using MER/SKY (Phospho-Tyr749/681) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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