Mesothelin antibody

Principal name

Mesothelin antibody

Alternative names for Mesothelin antibody

MSLN, MPF, CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor

SwissProt ID

Q13421 (Human), Q13421-3, Q61468 (Mouse), Q9ERA7 (Rat)

Gene ID

10232 (MSLN), 56047 (Msln), 60333

Available reactivities

Hu (Human), Mky (Monkey), Bov (Bovine), Ms (Mouse), Rt (Rat)

Available hosts

Mouse, Rabbit, Rat, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), ELISA (detection) (E(detection)), Paraffin Sections (P), Immunoprecipitation (IP), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of Mesothelin antibody

Mesothelin is a glycosyl-phosphatidyl- inositol–anchored glycoprotein present on the cell surface of various human solid tumors. The mesothelin (MSLN) gene encodes a 71-kDa precursor protein that is processed to a 40-kDa glycosylphosphatidyl-inositol–anchored protein that composes the mature portion and an NH2-terminal 31-kDa fragment called megakaryocyte-potentiating factor that is released from the cell. Mesothelin is a tumor differentiation antigen present at low levels on a restricted set of normal adult tissues, such as mesothelium, but aberrantly over expressed in mesotheliomas, ovarian, and pancreatic cancers. The biological functions of mesothelin remain elusive. A recent study showed that mesothelin binds to MUC16/CA125, and that this interaction mediates cell adhesion, suggesting that there may be an important role for MUC16/CA125 and mesothelin in the metastatic spread of ovarian cancer.

General readings

Johnson,M.D., (2008) J. Histochem. Cytochem. 56 (6), 579-585

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Mesothelin antibody

  Rabbit polyclonal antibody to Mesothelin (mesothelin)  
Sample(30 ug of whole cell lysate). A:293T. 7.5% SDS PAGE. TA308767 diluted at 1:1000 Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Goat Anti-Mesothelin / MSLN Antibody  
(0.3ug/ml) staining of Human Placenta lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu E, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Mouse monoclonal Mesothelin antibody  
Western blotting using anti-mesothelin antibodies to detect mesothelin-Fc at 100 ng (lane 1), 25 ng (lane 2), 6 ng (lane 3), 2 ng (lane 4) and 0.4 ng (lane 5). Lane 6 contains 50 ng of CDC25-Fc. Proteins were separated on 4-20% gradient gel by SDS-PAGE followed by transfer to PVDF membrane. Primary antibody was used at 1 ?g/ml followed by reaction with ALP goat anti-mouse IgG and BCIP/NBT substrate. Reprinted with permission fromClin.Cancer Res. 11(16):5840-6. Mouse MB-G10 Purified Hu P, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Mouse monoclonal Mesothelin antibody  
Western blotting using anti-mesothelin antibodies to detect mesothelin-Fc at 100 ng (lane 1), 25 ng (lane 2), 6 ng (lane 3), 2 ng (lane 4) and 0.4 ng (lane 5). Lane 6 contains 50 ng of CDC25-Fc. Proteins were separated on 4-20% gradient gel by SDS-PAGE followed by transfer to PVDF membrane. Primary antibody was used at 1 µg/ml followed by reaction with ALP goat anti-mouse IgG and BCIP/NBT substrate. Reprinted with permission fromClin.Cancer Res. 11(16):5840-6. Mouse MN-1 Purified Hu E, IP, P, WB
0.1 mg / €356.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Rabbit Polyclonal Anti-MSLN Antibody  
The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using (MSLN Antibody) at dilution 1/50, on the right is treated with fusion protein. (Original magnification: ×200) Rabbit IgG Purified Hu E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Rabbit Polyclonal anti-Mesothelin Antibody  
Human Mesothelioma stained with anti-Mesothelin antibody. Rabbit IgG Purified Hu P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Rabbit Monoclonal anti-Mesothelin Antibody  
Human Mesothelioma stained with anti-Mesothelin antibody. Rabbit IgG SP74 Purified Hu F, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Rabbit Polyclonal Mesothelin Antibody  
ELISA: Mesothelin Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  Rabbit Polyclonal Mesothelin Antibody  
ELISA: Mesothelin Antibody Rabbit IgG Purified Hu E
0.1 mg / €325.00
  OriGene Technologies, Inc.

Mesothelin antibody

  MSLN mouse monoclonal antibody, clone OTI4H6 (formerly 4H6)  
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MSLN mouse monoclonal antibody. (TA805129; heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min) Mouse IgG1 OTI4H6 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mesothelin antibody

  MSLN mouse monoclonal antibody, clone OTI1G8 (formerly 1G8)  
Immunohistochemical staining of paraffin-embedded Human tonsil within the normal limits using anti-MSLN mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120C for 3min, TA805169) Mouse IgG1 OTI1G8 Purified Hu P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mesothelin antibody

  MSLN mouse monoclonal antibody, clone OTI5B12 (formerly 5B12)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSLN (RC202532, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSLN. Mouse IgG1 OTI5B12 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mesothelin antibody

  MSLN mouse monoclonal antibody, clone OTI2E5 (formerly 2E5)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSLN (RC202532, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSLN. Mouse IgG1 OTI2E5 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mesothelin antibody

  MSLN mouse monoclonal antibody, clone OTI8H7 (formerly 8H7)  
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MSLN (RC202532, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MSLN. Mouse IgG1 OTI8H7 Purified Hu WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

TrueMAB

Mesothelin antibody

Mesothelin Mouse IgG1 K1 Ascites Hu, Mky C
1 ml / €770.00
  Acris Antibodies GmbH

Mesothelin antibody

Flow cytometric analysis of mouse mesothelinexpression on LO cells. Open histogram indicates the reaction of isotypic control to the cells. Shaded histogram indicates the reaction of AM26431AF-N to the cells. Rat IgG2a 295D Azide Free Ms F
0.1 mg / €390.00
  Acris Antibodies GmbH

Mesothelin antibody

Flow cytometric analysis of mouse Mesothelin expression on Jurkat(left) and LO (right). Open histograms indicate the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26431RP-N to the cells. Rat IgG2a 295D PE Ms F
50 Tests / €390.00
  Acris Antibodies GmbH

Mesothelin antibody

Flow cytometric an alysis of mouse Mesothelin expression on LO (left) and Jurkat (right). Open histogram indicates the reaction of isotypic control to the cells. Shaded histograms indicate the reaction of AM26533AF-N to the cells. Rat IgG2a B35 Azide Free Hu, Ms F
0.1 mg / €390.00
  Acris Antibodies GmbH

CRISPR

Catalog No. Species Donor Vector  

MSLN - human gene knockout kit via CRISPR

MSLN - human gene knockout kit via CRISPR Human GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

MSLN - human gene knockout kit via CRISPR

MSLN - human gene knockout kit via CRISPR Human mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

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