Methotrexate antibody

Principal name

Methotrexate antibody

Alternative names for Methotrexate antibody

4-amino-10-methylpteroyl-L-glutamic acid

Available reactivities

All Species

Available hosts

Sheep, Goat

Available applications

Enzyme Immunoassay (E)

Background of Methotrexate antibody

Methotrexate (rINN) abbreviated MTX and formerly known as amethopterin, is an antimetabolite and antifolate drug used in treatment of cancer, autoimmune diseases and as an abortifacient in the induction of medical abortions. It acts by inhibiting the metabolism of folic acid. Methotrexate competitively inhibits dihydrofolate reductase (DHFR), an enzyme that participates in the tetrahydrofolate synthesis. The affinity of methotrexate for DHFR is about one thousand-fold that of folate for DHFR. Methotrexate acts specifically during DNA and RNA synthesis, and thus it is cytotoxic during the S-phase of the cell cycle. Logically, it therefore has a greater toxic effect on rapidly dividing cells which replicate their DNA more frequently, and thus inhibits the growth and proliferation of these non-cancerous cells. Lower doses of methotrexate have been shown to be very effective for the management of rheumatoid arthritis, Crohn's disease, and psoriasis.

4 Item(s)

per page

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

Methotrexate antibody

Methotrexate Sheep IgG Serum E
0.5 ml / €400.00
  Acris Antibodies GmbH

Methotrexate antibody

Methotrexate Sheep IgG Ig Fraction E
0.1 ml / €500.00
  Acris Antibodies GmbH

Methotrexate antibody

Methotrexate Sheep IgG Serum
0.25 ml / €360.00
  Novus Biologicals Inc.

Methotrexate antibody

Methotrexate Goat All Species E
0.1 ml / €400.00
  Novus Biologicals Inc.

4 Item(s)

per page
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