mGluR1a / GRM1a antibody

Principal name

mGluR1a / GRM1a antibody

Alternative names for mGluR1a / GRM1a antibody

Metabotropic glutamate receptor 1, Gprc1a, Mglur1

SwissProt ID

P23385 (Rat), P97772 (Mouse), Q13255 (Human), Q13255-1

Gene ID

2911 (GRM1), 24414 (Grm1), 14816

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey), Bt (Bat), Can (Canine), Eq (Equine), Hst (Hamster), Rb (Rabbit)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), Flow Cytometry (F)

Background of mGluR1a / GRM1a antibody

L-Glutamate is the major excitatory neurotransmitter in the central nervous system. It operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and sigl transduction. Group I of the metabotropic glutamate receptors includes the mGluR1 and mGluR5 receptors. The receptors present the typical G-protein coupled receptor (GPCR) sigture topology: seven transmembrane domains with a large extracellular N-terminus domain and an intracellular C-terminus one. The N-terminus domain of Group I receptors contains the glutamate binding site while the cytoplasmic C-terminus domain has an important role in the regulation of receptor activity through interactions with other proteins such as the Homer adaptor proteins. mGluR1 and mGluR5 receptors sigl through Gq/G11 that activates phospholipase C and ultimately produces an increase in inositol trisphosphate and cytosolic Ca2+. More downstream sigling pathways include activation of PKC and modulation of Ca2+ and K+ ion channels. Activation of sigling pathways independent of G-proteins has also been reported. mGluR1 is predomintly expressed in nervous tissue although expression in several non-neural cell types has also been described. In the brain it is highly expressed in the hippocampus, cerebellum, olfactory bulb and thalamus. The mGluR1 receptor is involved in several physiological processes such as neurol development, induction of long-term potentiation (LTP) and depression (LTD) as well as in pathological disorders such as brain trauma, chronic pain, Parkinsonâ??s and Huntingtonâ??s disease.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR1a / GRM1a antibody

Western blot analysis of rat brain lysate: 1. Anti-mGluR1 (extracellular) antibody, (1:200). 2. Anti-mGluR1 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Human brain stained with Anti-GluR1 antibody Rabbit Purified Hu, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

mGluR1a / GRM1a antibody

Human brain stained with Anti-GluR1 antibody Rabbit Purified Hu, Ms, Rt P
1 ml / €440.00
  Acris Antibodies GmbH

mGluR1a / GRM1a antibody

Human brain stained with Anti-GluR1 antibody Rabbit Purified Hu, Ms, Rt P
0.1 ml / €180.00
  Acris Antibodies GmbH

mGluR1a / GRM1a antibody

Human brain stained with Anti-mGluR1 antibody Rabbit Purified Chk, Hu, Mky, Ms, Rt P
0.5 ml / €360.00
  Acris Antibodies GmbH

mGluR1a / GRM1a antibody

Human brain stained with Anti-mGluR1 antibody Rabbit Purified Chk, Hu, Mky, Ms, Rt P
1 ml / €520.00
  Acris Antibodies GmbH

mGluR1a / GRM1a antibody

Human brain stained with Anti-mGluR1 antibody Rabbit Purified Chk, Hu, Mky, Ms, Rt P
0.1 ml / €190.00
  Acris Antibodies GmbH

mGluR1a / GRM1a (C-term) antibody

Western blot of 10 ug of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomer and the ~250k dimer of mGluR1a.  The mGluR1a antibody shows no reactivity toward mGluR5. Rabbit IgG Aff - Purified Rt C, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using GRM1 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Predicted band size: 132 kDa . Positive control: Hela cell lysate. Recommended dilution: 1/500-2000. (Gel: 8%SDS-PAGE Lysate: 60 ug Primary antibody: 1/125 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute) Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Predicted cell location: Cytoplasm. Positive control: Human colon and ovarian cancer tissue. Recommended dilution: 1/10-50  The image on the left is immunohistochemistry of paraffin-embedded Human colon and ovarian cancer tissue using GRM1 antibody at dilution 1/10, on the right is treated with the synthetic peptide. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Western Blot: metabotropic Glutamate Receptor 1a Antibody [TA336498] - Detection of  metabotropic Glutamate Receptor 1a protein in 20ug of human brain lysate (lane 2) with the use of TA336498 as a primary antibody at 1:1000 dilution and an AP conjugated s Rabbit Purified Hu, Ms, Rt C, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

metabotropic Glutamate Receptor 1a Antibody [TA336513] - WB detection of GluR1 in 20 ug of human brain lysate (lane 2) with GluR1 polyclonal antibody at 1:1000 dilution followed by AP-conjugated secondary at 1:5000 dilution. Lane 1 represents the MW marke Rabbit Purified Chk, Hu, Ms, Rt C, ICC/IF, P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a (C-term) antibody

Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a (Extracell. Dom.) antibody

Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a (cytoplasm. Dom.) antibody

Anti-GRM1 / MGLUR1 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

ELISA: mGluR1 Antibody - Metabotropic Glutamate Receptor 1 Antibody Rabbit IgG Purified Hu E
50 µg / €325.00
  OriGene Technologies, Inc.

mGluR1a / GRM1a antibody

Western blot analysis using mGluR1a receptor antibody on HEK-293 cell lysate. Rabbit IgG Aff - Purified Rt C, WB
10 Blots / €460.00
  Acris Antibodies GmbH

mGluR1a / GRM1a (C-term) antibody

AP08368PU-N mGluR1a/GRM1a staining of Formalin-Fixed, Paraffin-Embedded Human Brain, cerebellum at 20 µg/ml followed by biotinylated Goat anti-Rabbit IgG secondary antibody, Alkaline Phosphatase-Streptavidin and Chromogen. Rabbit IgG Aff - Purified Hu, Ms, Rt IP, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

mGluR1a / GRM1a (C-term) antibody

Human Prostate (formalin-fixed, paraffin-embedded) stained with GRM1 antibody AP22697PU-N at 15 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Aff - Purified Hu P
0.25 ml / €470.00
  Acris Antibodies GmbH

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