mGluR2 / GRM2 antibody

Principal name

mGluR2 / GRM2 antibody

Alternative names for mGluR2 / GRM2 antibody

Metabotropic glutamate receptor 2, GPRC1B

SwissProt ID

P31421 (Rat), Q14416 (Human), Q14BI2 (Mouse)

Gene ID

2912 (GRM2), 24415 (Grm2), 2891 (GRIA2), 108068

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Bt (Bat), Can (Canine), Eq (Equine), Hst (Hamster), Mky (Monkey), Rb (Rabbit), Bear, Gorilla

Available hosts

Rabbit, Mouse, Goat, Chicken

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Frozen Sections (C), ELISA (detection) (E(detection))

Background of mGluR2 / GRM2 antibody

L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and sigl transduction. Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) sigture topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus one. mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation. mGluR2 is widely distributed throughout the brain with high expression in several limbic areas including the cortex, hippocampus and amygdala. mGluR2 is localized primarily presiptically, although postsyptical localization has also been described. In line with its presyptical localization, mGluR2 is thought to function as an autoreceptor in a negative feedback mechanism that suppress further release of glutamate from the cell on which it is expressed. The involvement of mGluR2 in neurol excitability and syptic transmission suggests that modulation of this receptor is a promising strategy for the treatment of neurological and neuropsychiatric disorders such as anxiety, schizophrenia, and pain.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGLUR2 antibody

Western blot analysis of mGLUR2 expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

mGLUR2 antibody

Western blot analysis of mGLUR2 expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

mGLUR2 antibody

Western blot analysis of mGLUR2 expression in HEK293T (A); SHSY5Y (B) whole cell lysates. Rabbit Aff - Purified Hu, Mky, Ms, Rt WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

mGluR2 / GRM2 (N-term) antibody

Anti-MGLUR2 / GLUR2 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 2.5-5 ug/ml. Rabbit Aff - Purified Bear, Bov, Bt, Can, Elephant, Eq, Hst, Hu, Mky, Ms, Platypus, Por, Rb, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Western blot of 10 ug of rat hippocampal lysate showing the specific immunolabeling of the ~110k monomer and the ~220k dimer of mGluR2 and mGluR3. Rabbit IgG Purified Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

(1ug/ml) staining of Human Hippocampus lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Purified Bov, Can, Hu, Ms, Rb, Rt P, WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue using GRM2 antibody.The picture on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms E, ICC/IF, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 (N-term) antibody

Anti-GRM2 / MGLUR2 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Bov, Hu, Ms, Por, Rt ICC/IF, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Western blot analysis of GluR2 expression in Mouse braintissue lysates,The lane on the left is treated with the antigen-specific peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Western blot analysis on mouse brain cell lysate using mGluR2/3 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Western blot analysis of rat cerebellum (lanes 1 and 3) and cortex (lanes 2 and 4) membranes: 1, 2. Anti-mGluR2 (extracellular) antibody, (1:400). 3, 4. Anti-mGluR2 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Anti-GRM2 / MGLUR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Eq, Hu, Mky, Ms
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

Anti-GRM2 / MGLUR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Bov, Bt, Can, Eq, Hu, Mky WB
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR2 / GRM2 antibody

mGluR2 staining of pyramidal neuron in the hippocampal formation of an adult transgenic Mouse brain (red satining). Green staining is GFP-immunoreactivity for a subpopulation of cortical neurons. Chicken Ig Purified Hu, Ms C, ICC/IF
1.0 ml / €440.00
  Acris Antibodies GmbH

mGluR2 / GRM2 antibody

mGluR2 / GRM2 Rabbit Serum Hu, Ms, Rt C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

mGluR2 / GRM2 antibody

mGluR2 / GRM2 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

mGluR2 / GRM2 antibody

Immunofluorescence of purified MaxPab antibody to GRM2 on 293 cell. [antibody concentration 1 ug/ml] Mouse Purified Hu E(detection), ICC/IF
50 µg / €370.00
  Abnova Taiwan Corp.

mGluR2 / GRM2 antibody

Detection limit for recombinant GST tagged GRM2 is approximately 0.3ng/ml as a capture antibody. Mouse IgG2a 3H7 Purified Hu E
0.1 mg / €370.00
  Abnova Taiwan Corp.

mGluR2 / GRM2 antibody

mGluR2 / GRM2 Rabbit Bov, Hu, Ms, Rt C, WB
0.1 ml / €470.00
  Abnova Taiwan Corp.

mGluR2 / GRM2 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR2/3 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

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