mGluR3 / GRM3 antibody

Principal name

mGluR3 / GRM3 antibody

Alternative names for mGluR3 / GRM3 antibody

Metabotropic glutamate receptor 3, GPRC1C, MGLUR3

SwissProt ID

P31422 (Rat), Q14832 (Human), Q5RAL3 (Ponab), Q9QYS2 (Mouse)

Gene ID

2913 (GRM3), 24416 (Grm3)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Eq (Equine), GP (Guinea Pig), Por (Porcine), Rb (Rabbit), Ze (Zebrafish)

Available hosts

Rabbit, Mouse, Chicken

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Dot blot (Dot), Frozen Sections (C), Flow Cytometry (F)

Background of mGluR3 / GRM3 antibody

L-Glutamate, the major excitatory neurotransmitter in the central nervous system, operates through several receptors that are categorized as ionotropic (ligand-gated cation channels) or metabotropic (G-protein coupled receptors). The metabotropic glutamate receptors family includes eight members (mGluR1-8) that have been divided into three groups based on their sequence homology, pharmacology and sigl transduction. Group II of the metabotropic glutamate receptors includes the mGluR2 and mGluR3 receptors. The receptors present the typical G-protein coupled receptor (GPCR) sigture topology: seven transmembrane domains with a large extracellular N-terminus domain that contains the glutamate binding site, and an intracellular C-terminus one. mGluR2 and mGluR3 are coupled to Gi/Go and hence inhibit cAMP formation following receptor activation. mGluR3 is expressed in neurons and glia in many brain regions including cerebral cortex, hippocampus and brain stem. mGluR3 expression is predomintly presyptic consistent with its role as an inhibitory autoreceptor, that is, activation of mGluR3 by glutamate inhibits additiol glutamate release from the same neurons. Several lines of evidence suggest that mGluR3 is important for long term depression, glial function and neuroprotection. Some studies, though not all, have shown genetic association of mGluR3 gene polymorphisms with psychosis and with schizophrenia-related phenotypes. Based in these findings, mGluR3 has been suggested as a therapeutic target for both psychosis and schizophrenia.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR3 / GRM3 antibody

Western blot analysis of extracts from mouse brain, using GluR2/3 antibody (#TA313973).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Predicted cell location: Cytoplasm,Cell membrane . Positive control: Human brain tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using GRM3 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Predicted cell location: Cytoplasm,Cell membrane . Positive control: Human brain and liver cancer tissue . Recommended dilution: 1/50-200  The image on the left is immunohistochemistry of paraffin-embedded human brain tissue using GRM3 antibody at dilution 1/50, on the right is treated with the fusion protein. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Predicted band size: 99 kDa . Positive control: 293T cell lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/400 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Predicted band size: 99 kDa . Positive control: Mouse brain tissue lysate. Recommended dilution: 1/200-1000. (Gel: 8%SDS-PAGE Lysate: 40 ug Primary antibody: 1/250 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 2 minutes) Rabbit IgG Purified Hu, Ms, Rt E, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-mGluR3 (extracellular) antibody, (1:600). 3, 4. Anti-mGluR3 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Western blot analysis of extracts of various cell lines, using GRM3 antibody. Rabbit IgG Purified Hu, Ms, Rt
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Host: Rabbit; Target Name: GRM3; Sample Tissue: 293T Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Host: Rabbit; Target Name: GRM3; Sample Tissue: NCI-H226 Whole Cell lysates; Antibody Dilution: 1.0 ug/ml Rabbit IgG Purified Bov, Can, Eq, Hu, Ms, Rb, Rt WB
50 µg / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

Western blot analysis of GluR2/3 expression in mouse brain Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR3 / GRM3 antibody

mGluR3 staining of pyramidal neurons in the hippocampal formation of an adult transgenic Mouse brain (red satining). Green staining isGFP-immunoreactivity of a subpopulation of cortical neurons. Chicken Ig Purified Hu, Ms C, ICC/IF
1.0 ml / €440.00
  Acris Antibodies GmbH

mGluR3 / GRM3 antibody

mGluR3 / GRM3 Rabbit Serum Hu, Ms, Rt C, E, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

mGluR3 / GRM3 (N-term Extracel. Dom.)) antibody

Cells expressing vector only - immunostained with target antibody Rabbit Aff - Purified Bear, Bov, Chk, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Xen ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

mGluR3 / GRM3 (N-term Extracel. Dom.)) antibody

Immunohistochemical staining of Brain (Neurons and glia) using anti- GRM3 antibody SP4399P Rabbit Aff - Purified Bear, Bt, Elephant, Eq, Hst, Hu, Mky, Ms, Op, Prim, Rb, Rt ICC/IF, P, WB
50 µg / €470.00
  Acris Antibodies GmbH

mGluR3 / GRM3 (N-term, Extracel. Dom.)) antibody

Immunohistochemical staining of Brain (Pituitary) using anti GRM3 antibody SP4400P after heat-induced antigen retrieval. Rabbit Aff - Purified Av, Bear, Bov, Elephant, Eq, Hst, Hu, L, Mky, Ms, Op, Platypus, Por, Prim, Rt, Tr ICC/IF, P
50 µg / €470.00
  Acris Antibodies GmbH

mGluR3 / GRM3 antibody

mGluR3 / GRM3 Mouse Serum Hu E, WB
50 µl / €290.00
  Abnova Taiwan Corp.

mGluR3 / GRM3 antibody

mGluR3 / GRM3 Rabbit Hu E
0.4 ml / €390.00
  Abnova Taiwan Corp.

mGluR3 / GRM3 antibody

Adult mouse cochlear ganglion stained with mGluR3 (green), Tuj-1 (red) and DAPI (blue). Chicken Aff - Purified Hu, Ms C, ICC/IF
0.1 ml / €210.00
  Neuromics Antibodies

mGluR3 / GRM3 (transfected cells only) antibody

mGluR3 / GRM3 Rabbit Aff - Purified Rt WB
0.1 ml / €250.00
  Neuromics Antibodies

mGluR3 / GRM3 antibody

Western Blot: Metabotropic Glutamate Receptor 3 Antibody [NBP1-31109] - Western blot analysis of Metabotropic Glutamate Receptor 3 Antibody on: A:293T B:A431 7.5% SDS PAGE diluted at 1:500 Rabbit IgG Bov, Hu, Ms, Rt Dot, WB
0.1 ml / €420.00
  Novus Biologicals Inc.

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