mGluR4 / GRM4 antibody

Principal name

mGluR4 / GRM4 antibody

Alternative names for mGluR4 / GRM4 antibody

Metabotropic glutamate receptor 4, GPRC1D, MGLUR4

SwissProt ID

P31423 (Rat), Q14833 (Human), Q68EF4 (Mouse)

Gene ID

2914 (GRM4), 24417 (Grm4)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey), Can (Canine), Hst (Hamster)

Available hosts

Rabbit, Mouse

Available applications

Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Flow Cytometry (F)

Background of mGluR4 / GRM4 antibody

Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi. The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translatiol modifications like phosphorylation as well as protein-protein interactions. The C-termil region is also subject to altertive splicing. mGluR4 is predomintly expressed presyptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or umi). mGluR4 knock out mice display impaired cerebellar syptic plasticity as well as some learning disabilities. In addition, this receptor has emerged as a target for the treatment of Parkinsonâ??s disease.

General readings

1. Wang H  et al. Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain. Neuroreport 22:244-8 (2011).

16 Item(s)

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR4 / GRM4 antibody

Western blot analysis of extracts from 293 cells, untreated or treated with Forskolin (40nM, 30mins), using GluR4 antibody (#TA311658).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human lung and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using GRM4 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

Predicted cell location: Cytoplasm, Nucleus. Positive control: Human breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using GRM4 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

Western blot analysis on 293 cell lysate using mGluR4 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-mGluR4 (extracellular) antibody, (1:200). 3, 4. Anti-mGluR4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

Anti-GRM4 / MGLUR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 (C-term) antibody

Anti-MGLUR4 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 19 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

mGluR4 / GRM4 Rabbit Serum Hu E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

mGluR4 / GRM4 antibody

mGluR4 / GRM4 Mouse Hu WB
0.5 mg / €1,400.00
  Abnova Taiwan Corp.

mGluR4 / GRM4 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

mGluR4 / GRM4 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

mGluR4 / GRM4 antibody

Immunohistochemical analysis of mGLUR4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt ICC/IF, P, WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

mGluR4 / GRM4 antibody

Immunohistochemical analysis of mGLUR4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt ICC/IF, P, WB
0.1 ml / €270.00
  Cohesion Biosciences Ltd.

mGluR4 / GRM4 antibody

Immunohistochemical analysis of mGLUR4 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Rabbit Aff - Purified Chk, Hu, Mky, Ms, Rt ICC/IF, P, WB
0.2 ml / €440.00
  Cohesion Biosciences Ltd.

mGluR4 / GRM4 antibody

mGluR4 / GRM4 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €360.00
  Novus Biologicals Inc.

mGluR4 / GRM4 antibody

mGluR4 / GRM4 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €290.00
  Novus Biologicals Inc.

16 Item(s)

per page
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