mGluR4 / GRM4 antibody

Principal name

mGluR4 / GRM4 antibody

Alternative names for mGluR4 / GRM4 antibody

Metabotropic glutamate receptor 4, GPRC1D, MGLUR4

SwissProt ID

P31423 (Rat), Q14833 (Human), Q68EF4 (Mouse)

Gene ID

2914 (GRM4), 24417 (Grm4), 268934

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Chk (Chicken), Mky (Monkey)

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of mGluR4 / GRM4 antibody

Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi. The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translatiol modifications like phosphorylation as well as protein-protein interactions. The C-termil region is also subject to altertive splicing. mGluR4 is predomintly expressed presyptically in neurons and in the cerebellum. A splice variant of the protein is expressed in taste buds. This variant lacks a large portion of the N-terminus and is normally referred to taste mGluR4. It is responsible (along with taste mGluR1) for mediating the taste of monosodium glutamate (or umi). mGluR4 knock out mice display impaired cerebellar syptic plasticity as well as some learning disabilities. In addition, this receptor has emerged as a target for the treatment of Parkinsonâ??s disease.

General readings

1. Wang H  et al. Spinal metabotropic glutamate receptor 4 is involved in neuropathic pain. Neuroreport 22:244-8 (2011).

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR4 / GRM4 antibody

  Rabbit polyclonal anti-GluR4 antibody  
Western blot analysis of extracts from 293 cells, untreated or treated with Forskolin (40nM, 30mins), using GluR4 antibody (#TA311658).The lane on the right is treated with the synthesized peptide. Rabbit IgG Purified Hu, Ms, Rt E, P, WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

  Anti-GRM4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human lung and ovarian cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using GRM4 antibody at dilution 1/20, on the right is treated with the synthetic peptide. (Original magnification:x 200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

  Anti-GRM4 Rabbit Polyclonal Antibody  
Predicted cell location: Cytoplasm, Nucleus. Positive control: Human breast cancer tissue. Recommended dilution: 1/25-100  The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using GRM4 antibody at dilution 1/15, on the right is treated with the synthetic peptide. (Original magnification: x200) Rabbit IgG Purified Hu, Ms, Rt E, P
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

  Rabbit Polyclonal mGluR4 Antibody  
Western blot analysis on 293 cell lysate using mGluR4 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 ml / €325.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

  Rabbit Polyclonal Anti-mGluR4 (extracellular)  
Western blot analysis of rat (lanes 1 and 3) and mouse (lanes 2 and 4) brain membranes: 1, 2. Anti-mGluR4 (extracellular) antibody, (1:200). 3, 4. Anti-mGluR4 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

  Rabbit Polyclonal Anti-GRM4 Antibody (N-Terminus)  
Anti-GRM4 / MGLUR4 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Purified Hu
50 µg / €400.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 (C-term) antibody

  Rabbit Polyclonal Anti-GRM4 Antibody (C-Terminus)  
Anti-MGLUR4 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 19 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €400.00
  OriGene Technologies, Inc.

mGluR4 / GRM4 antibody

mGluR4 / GRM4 Rabbit Serum Hu E, ICC/IF, WB
0.2 ml / €400.00
  Acris Antibodies GmbH

mGluR4 / GRM4 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €230.00
  Assay Biotech

mGluR4 / GRM4 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR4 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
  Assay Biotech

CRISPR

Catalog No. Species Donor Vector  

Grm4 - mouse gene knockout kit via CRISPR

Grm4 - mouse gene knockout kit via CRISPR Mouse GFP-Puro
1 kit / €1,200.00
  OriGene Technologies, Inc.

Grm4 - mouse gene knockout kit via CRISPR

Grm4 - mouse gene knockout kit via CRISPR Mouse mBFP-Neo
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grm4 - mouse gene knockout kit via CRISPR

Grm4 - mouse gene knockout kit via CRISPR Mouse Luciferase-Puro
1 kit / €1,290.00
  OriGene Technologies, Inc.

Grm4 - mouse gene knockout kit via CRISPR

Grm4 - mouse gene knockout kit via CRISPR Mouse RFP-BSD
1 kit / €1,290.00
  OriGene Technologies, Inc.

Human Lenti ORF Particles

Catalog No.    

Lenti ORF particles, GRM4 (mGFP-tagged) - Human glutamate receptor, metabotropic 4 (GRM4), 200 uL, >10^7 TU/mL

Lenti ORF particles, GRM4 (mGFP-tagged) - Human glutamate receptor, metabotropic 4 (GRM4), 200 uL, >10^7 TU/mL  
200 µl / €1,050.00
  OriGene Technologies, Inc.

Lenti ORF particles, GRM4 (Myc-DDK tagged) - Human glutamate receptor, metabotropic 4 (GRM4) , 200 uL, >10^7 TU/mL

Lenti ORF particles, GRM4 (Myc-DDK tagged) - Human glutamate receptor, metabotropic 4 (GRM4) , 200 uL, >10^7 TU/mL  
200 µl / €940.00
  OriGene Technologies, Inc.

Mouse Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grm4 (GFP-tagged) - Mouse glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grm4 (GFP-tagged) - Mouse glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL  
200 µl / €1,560.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grm4 (Myc-DDK-tagged) - Mouse glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grm4 (Myc-DDK-tagged) - Mouse glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL  
200 µl / €1,400.00
  OriGene Technologies, Inc.

Rat Lenti ORF Particles

Catalog No.    

Lenti ORF particles, Grm4 (GFP-tagged ORF) - Rat glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grm4 (GFP-tagged ORF) - Rat glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL  
200 µl / €1,660.00
  OriGene Technologies, Inc.

Lenti ORF particles, Grm4 (Myc-DDK-tagged ORF) - Rat glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL

Lenti ORF particles, Grm4 (Myc-DDK-tagged ORF) - Rat glutamate receptor, metabotropic 4 (Grm4), 200 uL, >10^7 TU/mL  
200 µl / €1,496.00
  OriGene Technologies, Inc.

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