mGluR7 / GRM7 antibody

Principal name

mGluR7 / GRM7 antibody

Alternative names for mGluR7 / GRM7 antibody

Metabotropic glutamate receptor 7, GPRC1G, MGLUR7

SwissProt ID

P35400 (Rat), Q14831 (Human), Q68ED2 (Mouse)

Gene ID

2917 (GRM7), 81672 (Grm7)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Can (Canine), Ze (Zebrafish), Rb (Rabbit), Eq (Equine), Mky (Monkey), GP (Guinea Pig), Por (Porcine)

Available hosts

Rabbit, Mouse, Goat

Available applications

Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C)

Background of mGluR7 / GRM7 antibody

Metabotropic glutamate receptors (mGluRs) belong to the super family of G-protein coupled receptors (seven transmembrane proteins). mGluRs are further divided into subfamilies: group I mGluRs (mGluR1 and mGluR5) which couple to Gq, thereby activating phospholipase C (PLC). Group II which include mGluR2 and mGluR3 couple to Gi, therefore inhibit the formation of adenylate cyclase. mGluR4, 6, 7, 8 which belong to group III also inhibit adenylate cyclase formation by coupling to Gi. The C-terminus of these receptors has important functions in modulating their activity. This region is important for G-protein coupling, post-translatiol modifications like phosphorylation as well as protein-protein interactions. The C-termil region is also subject to altertive splicing. Indeed, mGluR7 can be detected as five different splice variants. Like all group III metabotropic glutamate receptors, mGluR7 is localized presyptically. It is highly expressed in the central nervous system and could also be detected in some peripheral organs like hair cells and spiral ganglion cells of the inner ear. As opposed to other group III metabotropic glutamate receptors, mGluR7 has very low affinity for its substrate L-glutamate, therefore, only under high syptic activity is the receptor active. This ebles the receptor to act as a negative feedback loop by inhibiting the release of L-glutamate. mGluR7 may play a molecular role in the pathways leading to emotion and cognition.

General readings

Vadasz C, Saito M, Gyetvai BM, Oros M, Szakall I, Kovacs KM, Prasad VV, Toth R.
Glutamate receptor metabotropic 7 is cis-regulated in the mouse brain and modulates alcohol drinking.
Genomics. 2007 Dec;90(6):690-702. Epub 2007 Oct 23.
PMID: 17936574

  1. Quick-Filters:
  2. Highly Validated (1)

Items 1 to 20 of 30 total

per page
Page:
  1. 1
  2. 2

Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  

mGluR7 / GRM7 (N-term) antibody

Anti-GRM7 / MGLUR7 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Rabbit Aff - Purified Hu ICC/IF, P, WB
50 µg / €345.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

TA305625 (0.5ug/ml) staining of Human Cerebellum lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

Western blot analysis of mouse (lanes 1 and 4) and rat (lanes 2 and 5) brain membranes and human CCF-STTGI astrocytoma (lanes 3 and 6) cell line lysate (1:200): 1-3. Anti-mGluR7 (extracellular) antibody, (1:200). 4-6. Anti-mGluR7 (extracellular) antibody, preincubated with the control peptide antigen. Rabbit Purified Hu, Ms, Rt WB
0.2 ml / €435.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 (2nd Extracell. Dom.) antibody

Anti-GRM7 / MGLUR7 antibody IHC of human brain, cortex, neurons. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml. Rabbit Aff - Purified Bear, Bov, Can, Chk, Do, Elephant, Eq, Hu, Mky, Ms, Op, Por, Prim, Rb, Rt, Tr P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 (N-term, Extracell. Dom.) antibody

Anti-GRM7 / MGLUR7 antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 7 ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

Anti-GRM7 / MGLUR7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 4-6 ug/ml. Rabbit Purified Hu
50 µg / €379.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

WB Suggested Anti-GRM7 Antibody Titration: 0.2-1 ug/ml; ELISA Titer: 1:312500; Positive Control: 721_B cell lysate GRM7 is supported by BioGPS gene expression data to be expressed in 721_B Rabbit IgG Purified Bov, Can, Eq, GP, Hu, Ms, Por, Rb, Rt, Ze WB
50 µg / €325.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

Western blot analysis on HuvEc cell lysate using mGluR7 Antibody Rabbit IgG Purified Hu, Ms, Rt WB
0.1 mg / €325.00
  OriGene Technologies, Inc.

mGluR7 / GRM7 antibody

Western blot (WB) analysis of mGluR7 antibody (Cat.-No.: AP01318PU-N) n extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

mGluR7 / GRM7 antibody

Immunohistochemistry (IHC) analyzes of mGluR7 antibody (Cat.-No.: AP06142PU-N)  in Paraffin-Embedded Human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €350.00
  Acris Antibodies GmbH

mGluR7 / GRM7 pSer862 antibody

Western blot of mouse brain lysate showing the specific immunolabeling
of the ~102k mGluR7 protein phosphorylated at Ser862. Immunolabeling
is blocked by the phospho-peptide used as antigen (peptide) but not by the
corresponding dephospho-peptide (not shown). Rabbit IgG Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt, Ze C
0.1 ml / €380.00
  Acris Antibodies GmbH

mGluR7 / GRM7 antibody

Detection limit for recombinant GST tagged GRM7 is approximately 0.03ng/ml as a capture antibody. Mouse IgG 1H5 Purified Hu E, WB
0.1 mg / €370.00
  Abnova Taiwan Corp.

mGluR7 / GRM7 antibody

mGluR7 / GRM7 Mouse IgG 1H5 Ascites Hu E, WB
0.2 ml / €370.00
  Abnova Taiwan Corp.

mGluR7 / GRM7 antibody

GRM7 polyclonal antibody ( Cat # PAB12813 ) ( 0.5µg/ml ) staining of human cerebellum lysate ( 35µg protein in RIPA buffer ). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Hu E, WB
0.1 mg / €400.00
  Abnova Taiwan Corp.

mGluR7 / GRM7 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €205.00
  Assay Biotech

mGluR7 / GRM7 antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mGluR7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €310.00
  Assay Biotech

mGluR7 / GRM7 antibody

Immunofluorescence analysis of A549 cells, using GRM7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
50 µg / €205.00
  Assay Biotech

mGluR7 / GRM7 antibody

Immunofluorescence analysis of A549 cells, using GRM7 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, ICC/IF, WB
0.1 mg / €310.00
  Assay Biotech

mGluR7 / GRM7 (C-term) antibody

mGluR7 / GRM7 Rabbit Aff - Purified Hu WB
50 µg / €350.00
  AVIVA Systems Biology

mGluR7 / GRM7 antibody

Western blot analysis of mGLUR7 expression in EOC20 (A); rat brain (B) whole cell lysates. Rabbit Aff - Purified Can, Hu, Ms, Rb, Rt WB
30 µl / €190.00
  Cohesion Biosciences Ltd.

Items 1 to 20 of 30 total

per page
Page:
  1. 1
  2. 2
  • LinkedIn